The Neuroprotective Effects of Decursin Isolated from Angelica gigas Nakai Against Amyloid β-Protein-Induced Apoptosis in PC 12 Cells via a Mitochondria-Related Caspase Pathway

2015 ◽  
Vol 40 (8) ◽  
pp. 1555-1562 ◽  
Author(s):  
Li Li ◽  
Jikun Du ◽  
Liyi Zou ◽  
Haishan Xia ◽  
Tie Wu ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Neuroprotective Effects ◽  
Angelica Gigas ◽  
Angelica Gigas Nakai ◽  
Pc 12 Cells ◽  
Β Protein ◽  
Caspase Pathway ◽  
Induced Apoptosis

Prostaglandin E2 rescues cortical neurons from amyloid β protein-induced apoptosis

2003 ◽  
Vol 959 (2) ◽  
pp. 328-335 ◽  
Author(s):  
Tatsurou Yagami ◽  
Hitoshi Nakazato ◽  
Keiichi Ueda ◽  
Kenji Asakura ◽  
Takayuki Kuroda ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Cortical Neurons ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Induced Apoptosis

scholarly journals Tripchlorolide attenuates β-amyloid generation by inducing NEP activity in N2a/APP695 cells

2021 ◽  
Vol 12 (1) ◽  
pp. 301-308
Author(s):  
Yuqi Zeng ◽  
Yongkun Li ◽  
Hui Shen ◽  
Nan Lin ◽  
Jian Zhang
Keyword(s):  
Nitrosative Stress ◽  
Amyloid Β ◽  
Inflammatory Factors ◽  
Amyloid Β Protein ◽  
Neuroprotective Effects ◽  
Western Blots ◽  
Protein Levels ◽  
Cell Vitality ◽  
Β Protein ◽  
Aβ Generation

Abstract Background and purpose Alzheimer’s disease (AD) is a neurodegeneration disease. The previous work from our research group demonstrated the neuroprotective effects of tripchlorolide (T4) in AD animal models. Materials and methods Neprilysin (NEP) is known as an important physiological amyloid-β protein (Aβ) peptide-degrading enzyme in the brain due to its apparent rate-limiting function. In this study, we explored the effect of NEP on AD model N2a/APP695 cells. Western blots and enzyme-linked immunosorbent assays were performed to assess the expression of proteins, while quantitative real-time polymerase chain reaction assays were used to evaluate RNA levels. Cell vitality was detected by the MTT assay, and reactive oxygen species (ROS) levels were assessed using a ROS activity assay kit. Results We discovered that T4 was able to enhance the enzyme activity of NEP. T4 administration decreased the protein levels of the soluble amyloid precursor protein. In further experiments, we found that by using thiorphan the secretion of Aβ, oxidative stress, nitrosative stress, and inflammatory factors, which were suppressed by T4, were reversed. Due to its ability to attenuate Aβ generation and to protect neurons against the neurotoxicity of Aβ, T4 may be a potential therapy in the regulation of Aβ-related pathology in AD by affecting NEP activity. Conclusion Tripchlorolide attenuates Aβ generation by inducing NEP activity in N2a/APP695 cells.

scholarly journals The Role of 6-Gingerol on Inhibiting Amyloid β Protein-Induced Apoptosis in PC12 Cells

2015 ◽  
Vol 18 (5) ◽  
pp. 413-421 ◽  
Author(s):  
Gao-feng Zeng ◽  
Shao-hui Zong ◽  
Zhi-yong Zhang ◽  
Song-wen Fu ◽  
Ke-ke Li ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Induced Apoptosis

Tumor necrosis factor α augments amyloid β protein (25–35) induced apoptosis in human cells

1997 ◽  
Vol 238 (1-2) ◽  
pp. 17-20 ◽  
Author(s):  
I Blasko ◽  
T.L Schmitt ◽  
E Steiner ◽  
K Trieb ◽  
B Grubeck-Loebenstein
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Amyloid Β ◽  
Human Cells ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Induced Apoptosis ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells

Autophagy ◽  
2011 ◽  
Vol 7 (12) ◽  
pp. 1528-1545 ◽  
Author(s):  
Lin Zheng ◽  
Alexei Terman ◽  
Martin Hallbeck ◽  
Nodi Dehvari ◽  
Richard F. Cowburn ◽  
...  
Keyword(s):  
Neuroblastoma Cells ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Induced Apoptosis
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