Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress by Modulating the Hypothalamic–Pituitary–Adrenal Axis Function and Activating BDNF Signaling Pathway

2017 ◽  
Vol 42 (11) ◽  
pp. 3233-3244 ◽  
Author(s):  
Xianpeng Zu ◽  
Mingjian Zhang ◽  
Wencai Li ◽  
Haisheng Xie ◽  
Zhang Lin ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Bdnf Signaling ◽  
Pituitary Adrenal Axis

Hypothalamic-pituitary-adrenal axis responsivity to an acute novel stress in female rats subjected to the chronic mild stress paradigm

2019 ◽  
Vol 1723 ◽  
pp. 146402
Author(s):  
Guillermo A. Ariza Traslaviña ◽  
Fernanda Pedrosa Torres ◽  
Procópio Cleber Gama de Barcelos Filho ◽  
Fabiana Lucio-Oliveira ◽  
Celso Rodrigues Franci
Keyword(s):  
Chronic Mild Stress ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Female Rats ◽  
Mild Stress ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

scholarly journals GluN2A/ERK/CREB Signaling Pathway Involved in Electroacupuncture Regulating Hypothalamic-Pituitary-Adrenal Axis Hyperactivity

2021 ◽  
Vol 15 ◽  
Author(s):  
Yu Wang ◽  
Jing Han ◽  
Jing Zhu ◽  
Mizhen Zhang ◽  
Minda Ju ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Hpa Axis ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

Graphical AbstractSurgery induced HPA axis hyperactivity, while EA intervention inhibited the activation of hypothalamic GluN2A/ERK/CREB signaling pathway, thereby reducing the synthesis and secretion of CRH, alleviating the hyperactivity of the HPA axis after surgery.

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