Synthesis and Biological Activity of Quinoline-2-Carboxylic Acid Aryl Esters and Amides

2017 ◽  
Vol 51 (5) ◽  
pp. 351-354 ◽  
Author(s):  
V. D. Boyarshinov ◽  
A. I. Mikhalev ◽  
T. A. Yushkova ◽  
S. V. Ukhov ◽  
T. M. Kon’shina
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid

scholarly journals Isolation, Structure Elucidation, and Biological Activity of a New Alkaloid from Zanthoxylum rhetsa

2011 ◽  
Vol 6 (11) ◽  
pp. 1934578X1100601
Author(s):  
Karsten Krohn ◽  
Stephan Cludius-Brandt ◽  
Barbara Schulz ◽  
Mambatta Sreelekha ◽  
Pottachola Mohamed Shafi
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Medicinal Plant ◽  
Plant Extract ◽  
Structure Elucidation ◽  
Biologically Active ◽  
Reduction Product ◽  
Pharmacological Properties ◽  
Evergreen Tree

Several biologically active alkaloids (1-4, 6), including a new quinazoline-6-carboxylic acid (1), were isolated from the medicinal plant Zanthoxylum rhetsa, an evergreen tree, native to subtropical areas. Whereas the pharmacological properties of the plant extract and single constituents have been widely tested, we now show that all of the metabolites have antialgal activities, all but 6 are antibacterial, and 6 and the reduction product 5 (derived from 4) are also antifungal.

Biological Activity of Novel N-Substituted Amides of endo-3- (3-Methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene-2- carboxylic Acid and N-Substituted Amides of 1-(5-Methylthio- 1,2,4-triazol-3-yl)cyclohexane-2-carboxylic Acids

2012 ◽  
Vol 67 (3-4) ◽  
pp. 123-128
Author(s):  
Anna Pachuta-Stec ◽  
Urszula Kosikowska ◽  
Anna Chodkowska ◽  
Monika Pitucha ◽  
Anna Malm ◽  
...  
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Condensation Reaction ◽  
Primary Amines ◽  
Pharmacological Activities

N-Substituted amides of endo-3-(3-methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene- 2-carboxylic acid and 1-(5-methylthio-1,2,4-triazol-3-yl)cyclohexane-2-carboxylic acid were prepared by the condensation reaction of endo-S-methyl-N1-(bicyclo[2.2.1]hept-5-ene-2,3- dicarbonyl)isothiosemicarbazide and S-methyl-N1-(cyclohexane-2,3-dicarbonyl)isothiosemicarbazide with primary amines. The synthesized compounds were screened for their microbiological and pharmacological activities

Synthesis of 2-methylquinoline- and 2-arylamino-5,6,7,8-tetrahydroquinoline-3-carboxylic acid β-dialkalylaminoacetylhydrazides and their biological activity

1991 ◽  
Vol 25 (2) ◽  
pp. 89-92
Author(s):  
S. V. Ukhov ◽  
M. Yu. Gavrilov ◽  
S. N. Nikulina ◽  
V. É. Kolla ◽  
M. E. Konshin
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid

Synthesis and biological activity of carboxylic acid derivatives carrying sulfur-containing groups in the ?-position

1986 ◽  
Vol 20 (7) ◽  
pp. 496-500
Author(s):  
V. V. Znamenskii ◽  
A. D. Efremov ◽  
V. M. Bystrova ◽  
T. P. Vasil'eva ◽  
O. V. Kil'disheva
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Sulfur Containing

Substituted 5-Aroylpyrazine-2-carboxylic Acid Derivatives: Synthesis and Biological Activity.

ChemInform ◽  
2004 ◽  
Vol 35 (8) ◽  
Author(s):  
M. Dolezal ◽  
J. Jampilek ◽  
Z. Osicka ◽  
J. Kunes ◽  
V. Buchta ◽  
...  
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid

Synthesis of Hippospongic Acid A Analogues Designed for Investigating the Structure-Activity Relationship of its Biological Activity

2000 ◽  
Vol 53 (12) ◽  
pp. 909 ◽  
Author(s):  
Yoshikazu Hiraga ◽  
Mariko Ago ◽  
Munetaka Tokumasu ◽  
Ken Kaku ◽  
Katsuo Ohkata
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Sea Urchin ◽  
Essential Feature ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Acid Moiety ◽  
Sea Urchin Embryos ◽  
Structure Activity ◽  
Relationship Of

Analogues of hippospongic acid A, which inhibit the gastrulation of sea urchin embryos, were synthesized. From a study on structure—activity relationships, the conjugated carboxylic acid moiety was found to be an essential feature for biological activity.

Synthesis of New Polysubstituted Pyrrolidinones with Potential Biological Activity

2008 ◽  
Vol 63 (3) ◽  
pp. 313-320 ◽  
Author(s):  
Nikola T. Burdzhiev ◽  
Elena R. Stanoeva
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Succinic Anhydride ◽  
Potential Biological Activity ◽  
Pharmacological Interest ◽  
Aminomethyl Derivatives

The reaction of succinic anhydride and N-benzylidene-benzylamine gave rise to the corresponding substituted trans-5-oxopyrrolidine-3-carboxylic acid, which was transformed stereoselectively into two series of compounds. The first one consists of carboxamides, and the second one includes aminomethyl derivatives. The compounds prepared incorporate both a pyrrolidinone part and other nitrogen containing heterocyclic fragments of pharmacological interest.

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