Synthesis and biological activity of oxo-7H-benzo[e]perimidine-4-carboxylic acid derivatives as potent, nonpeptide corticotropin releasing factor (CRF) receptor antagonists

1999 ◽  
Vol 9 (5) ◽  
pp. 765-770 ◽  
Author(s):  
David R Luthin ◽  
Aleksandr K Rabinovich ◽  
Dilip R Bhumralkar ◽  
Kenna L Youngblood ◽  
Richard A Bychowski ◽  
...  
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Corticotropin Releasing Factor ◽  
Receptor Antagonists

ChemInform Abstract: Synthesis and Biological Activity of Oxo-7H-benzo[e]perimidine-4-carboxylic Acid Derivatives as Potent, Nonpeptide Corticotropin Releasing Factor (CRF) Receptor Antagonists.

ChemInform ◽  
2010 ◽  
Vol 30 (26) ◽  
pp. no-no
Author(s):  
David R. Luthin ◽  
Aleksandr K. Rabinovich ◽  
Dilip R. Bhumralkar ◽  
Kenna L. Youngblood ◽  
Richard A. Bychowski ◽  
...  
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Corticotropin Releasing Factor ◽  
Receptor Antagonists

scholarly journals Isolation, Structure Elucidation, and Biological Activity of a New Alkaloid from Zanthoxylum rhetsa

2011 ◽  
Vol 6 (11) ◽  
pp. 1934578X1100601
Author(s):  
Karsten Krohn ◽  
Stephan Cludius-Brandt ◽  
Barbara Schulz ◽  
Mambatta Sreelekha ◽  
Pottachola Mohamed Shafi
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Medicinal Plant ◽  
Plant Extract ◽  
Structure Elucidation ◽  
Biologically Active ◽  
Reduction Product ◽  
Pharmacological Properties ◽  
Evergreen Tree

Several biologically active alkaloids (1-4, 6), including a new quinazoline-6-carboxylic acid (1), were isolated from the medicinal plant Zanthoxylum rhetsa, an evergreen tree, native to subtropical areas. Whereas the pharmacological properties of the plant extract and single constituents have been widely tested, we now show that all of the metabolites have antialgal activities, all but 6 are antibacterial, and 6 and the reduction product 5 (derived from 4) are also antifungal.

Biological Activity of Novel N-Substituted Amides of endo-3- (3-Methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene-2- carboxylic Acid and N-Substituted Amides of 1-(5-Methylthio- 1,2,4-triazol-3-yl)cyclohexane-2-carboxylic Acids

2012 ◽  
Vol 67 (3-4) ◽  
pp. 123-128
Author(s):  
Anna Pachuta-Stec ◽  
Urszula Kosikowska ◽  
Anna Chodkowska ◽  
Monika Pitucha ◽  
Anna Malm ◽  
...  
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Condensation Reaction ◽  
Primary Amines ◽  
Pharmacological Activities

N-Substituted amides of endo-3-(3-methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene- 2-carboxylic acid and 1-(5-methylthio-1,2,4-triazol-3-yl)cyclohexane-2-carboxylic acid were prepared by the condensation reaction of endo-S-methyl-N1-(bicyclo[2.2.1]hept-5-ene-2,3- dicarbonyl)isothiosemicarbazide and S-methyl-N1-(cyclohexane-2,3-dicarbonyl)isothiosemicarbazide with primary amines. The synthesized compounds were screened for their microbiological and pharmacological activities

Characterisation and biological activity of Glu3 amino acid substituted GIP receptor antagonists

2007 ◽  
Vol 461 (2) ◽  
pp. 263-274 ◽  
Author(s):  
Victor A. Gault ◽  
Kerry Hunter ◽  
Nigel Irwin ◽  
Brian D. Green ◽  
Brett Greer ◽  
...  
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Receptor Antagonists ◽  
Gip Receptor

Synthesis and Biological Activity of Quinoline-2-Carboxylic Acid Aryl Esters and Amides

2017 ◽  
Vol 51 (5) ◽  
pp. 351-354 ◽  
Author(s):  
V. D. Boyarshinov ◽  
A. I. Mikhalev ◽  
T. A. Yushkova ◽  
S. V. Ukhov ◽  
T. M. Kon’shina
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid

Synthesis of 2-methylquinoline- and 2-arylamino-5,6,7,8-tetrahydroquinoline-3-carboxylic acid β-dialkalylaminoacetylhydrazides and their biological activity

1991 ◽  
Vol 25 (2) ◽  
pp. 89-92
Author(s):  
S. V. Ukhov ◽  
M. Yu. Gavrilov ◽  
S. N. Nikulina ◽  
V. É. Kolla ◽  
M. E. Konshin
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid
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