Impact of Silicone Oil on Free Fatty Acid Particle Formation due to Polysorbate 20 Degradation

2020 ◽  
Vol 37 (11) ◽  
Author(s):  
Raphael Fish ◽  
Jasper Lin ◽  
Nidhi Doshi
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Silicone Oil ◽  
Particle Formation ◽  
Polysorbate 20

Evaluating a Modified High Purity Polysorbate 20 Designed to Reduce the Risk of Free Fatty Acid Particle Formation

2021 ◽  
Vol 38 (9) ◽  
pp. 1563-1583 ◽  
Author(s):  
Nidhi Doshi ◽  
Kyle Ritchie ◽  
Tamanna Shobha ◽  
Jamie Giddings ◽  
Kathrin Gregoritza ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
High Purity ◽  
Particle Formation ◽  
Polysorbate 20

scholarly journals Glass Leachables as a Nucleation Factor for Free Fatty Acid Particle Formation in Biopharmaceutical Formulations

2020 ◽  
Author(s):  
Andrea Allmendinger ◽  
Vanessa Lebouc ◽  
Lucia Bonati ◽  
Anne Woehr ◽  
Ravuri S.K. Kishore ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Particle Formation

Residual Host Cell Protein Promotes Polysorbate 20 Degradation in a Sulfatase Drug Product Leading to Free Fatty Acid Particles

2016 ◽  
Vol 105 (5) ◽  
pp. 1657-1666 ◽  
Author(s):  
Nitin Dixit ◽  
Nazila Salamat-Miller ◽  
Paul A. Salinas ◽  
Katherine D. Taylor ◽  
Sujit K. Basu
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Host Cell ◽  
Drug Product ◽  
Cell Protein ◽  
Host Cell Protein ◽  
Polysorbate 20

Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM

Diabetes ◽  
1988 ◽  
Vol 37 (8) ◽  
pp. 1020-1024 ◽  
Author(s):  
G. M. Reaven ◽  
C. Hollenbeck ◽  
C. Y. Jeng ◽  
M. S. Wu ◽  
Y. D. Chen
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Plasma Glucose

Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin

Diabetes ◽  
1995 ◽  
Vol 44 (9) ◽  
pp. 1038-1045 ◽  
Author(s):  
K. Rebrin ◽  
G. M. Steil ◽  
L. Getty ◽  
R. N. Bergman
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Hepatic Glucose Output ◽  
Hepatic Glucose ◽  
Glucose Output
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