scholarly journals Adverse anthropometric risk profile in biochemically controlled acromegalic patients: comparison with an age- and gender-matched primary care population

Pituitary ◽  
2010 ◽  
Vol 13 (3) ◽  
pp. 207-214 ◽  
Author(s):  
C. Dimopoulou ◽  
C. Sievers ◽  
H. U. Wittchen ◽  
L. Pieper ◽  
J. Klotsche ◽  
...  
2017 ◽  
Vol 15 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Katinka Reiner ◽  
Tilly Eichler ◽  
Johannes Hertel ◽  
Wolfgang Hoffmann ◽  
Jochen Rene Thyrian

Objective: The primary aim of the study was to determine accuracy, sensitivity and specificity of the Clock Drawing Test (CDT) in detecting probable dementia as compared to the multi-domain dementia screening test DemTect. Methods: The sample was derived from the general practitioner (GP)-based, cluster-randomized controlled intervention trial DelpHi-MV (Dementia: life- and person-centered help in Mecklenburg-Western Pomerania). Selected from 6.440 patients systematically screened for dementia in primary care, we examined three groups (a,b,c) where the CDT (as index test) as well as the DemTect (as reference standard) were available. After excluding cases with missing values, we included a sample of n=462 with “probable dementia”, n=586 with “mild cognitive impairment” and n=553 with “no cognitive impairment” matched for age and gender. We analyzed the accuracy of the CDT in identifying people with probable dementia by the DemTect and report sensitivity, and specificity for the CDT. We further analyzed age and gender differences associated with the groups. Results: In comparison to the DemTect the CDT identified more than twice as many of the screened patients as cognitively impaired (63.1% in the CDT vs. 28.9% in the DemTect). The sensitivity and specificity for the CDT were 84.4% and 45.6% respectively. We found considerable age and gender differences for the performance of the CDT. Higher age (p < 0.001) and female sex (p < 0.001) were associated with incorrect clock drawings. Conclusion: The CDT shows a considerably high rate of false positive screening outcomes compared to the DemTect and disadvantages older people and women. Thus, in contrary to previous findings our results indicate that the CDT should not be used as exclusive instrument to screen for probable dementia in primary care.


2015 ◽  
Vol 105 (5) ◽  
pp. 421-431 ◽  
Author(s):  
Piercarlo Ballo ◽  
Irene Betti ◽  
Alessandro Barchielli ◽  
Daniela Balzi ◽  
Gabriele Castelli ◽  
...  

2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Alessandro Rizza ◽  
Vladimir Kaplan ◽  
Oliver Senn ◽  
Thomas Rosemann ◽  
Heinz Bhend ◽  
...  

Author(s):  
Josephine M. Keyzer ◽  
Johannes J. Hoffmann ◽  
Lianne Ringoir ◽  
Karin C. Nabbe ◽  
Jos W. Widdershoven ◽  
...  

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C Rammos ◽  
O Petrikhovich ◽  
A Mahabadi ◽  
M Steinmetz ◽  
J Lortz ◽  
...  

Abstract Background Cardiovascular diseases are the leading causes of death in the industrialized world. In addition to coronary heart disease, PAD defines morbidity and is associated with increased mortality. Guideline-recommended therapy and specialized ambulatory care is essential for optimal treatment. Knowledge of the treatment structures, contact with dedicated specialists and pharmacotherapy in the outpatient area are essential for improving treatment, reducing symptoms and finally improve mortality in this high-risk population. Methods The study is based on the ambulatory claims data of the panel doctors services according to § 295 SGB V and drug prescription data according to § 300 SGB V. The prevalence of PAD in Germany (medical diagnoses of PAD ICD I70.2–9) was analyzed by age and gender-specific characteristics with a timeframe of 10 years (2009–2018). In addition, the current ambulatory care structure was examined subdivided by vascular specialist (vascular surgeons or angiologists) and primary care physicians (internal medicine or general practitioners). Additionally, the prescription of guideline-recommended pharmacotherapy like statins and antiplatelet inhibitors was analyzed for the years 2009–2016. Results An increase of PAD diagnosis was observed with a maximum in 2018 with 2.280.000 patients in Germany. The rise of PAD patients strongly correlates with increased age (age group 50–59: 243.000, age group 60–69: 533.000, age group 70–79: 735.000, age group 75–79: 438.000, age group 80–89: 710.000) and more commonly affects males (55%) than females (45%). Access to vascular specialist was low for all age groups with only 11% of patients receiving care from vascular surgeons and only 9% from angiologists. However, 99% received care by a primary care physician. The prescription of lipid-lowering drugs and platelet aggregation inhibitors in the current analysis period from 2009–2016 is insufficient, with only 46% receiving statins and 29% receiving antiplatelets and 15% oral anticoagulation, Conclusion There are relevant differences in age and gender-specific prevalence of PAD in Germany. In addition to the regular care provided by primary care physicians, PAD patients are in need for specialized vascular care. Guideline recommended prescriptions are alarmingly low in PAD patients. There is a clear need to improve the treatment algorithms in the high-risk PAD population. Funding Acknowledgement Type of funding source: None


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