Effect of pentoxifylline on semen parameters, reproductive hormones, and seminal plasma antioxidant capacity in men with idiopathic infertility: a randomized double-blind placebo-controlled study

2010 ◽  
Vol 43 (2) ◽  
pp. 315-328 ◽  
Author(s):  
Mohammad Reza Safarinejad
Keyword(s):  
Antioxidant Capacity ◽  
Seminal Plasma ◽  
Reproductive Hormones ◽  
Semen Parameters ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Idiopathic Infertility ◽  
Plasma Antioxidant Capacity ◽  
Plasma Antioxidant

scholarly journals Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men

2013 ◽  
Vol 19 (No. 3) ◽  
pp. 106-110 ◽  
Author(s):  
V. Šimánek ◽  
N. Škottová ◽  
J. Bartek ◽  
J. Psotová ◽  
P. Kosina ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Biochemical Analysis ◽  
Serum Cholesterol Level ◽  
Hdl Cholesterol ◽  
Controlled Study ◽  
Positive Trend ◽  
Silybum Marianum ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Liver Parameters

In a randomized, double-blind, placebo-controlled study, the effect of an extract from Silybum marianum seeds (ESM, milk thistle extract) on lipid and liver parameters and the antioxidant capacity of serum was investigated in 29 healthy men aged 18–32 years. They received either 858 mg of ESM (531 mg silymarin complex calculated on pure silibinin), or placebo, daily for the period of 60 days. No side effects were found. A routine biochemical analysis of the serum was performed as a measure of lipid and liver metabolism. Positive trend towards decreased serum cholesterol level and HDL-cholesterol increase was observed in the ESM group as compared to the placebo group. The serum antioxidant capacity was significantly higher in the ESM group. The results suggest the use of ESM as a dietary supplement for hypercholesterolemia.

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