scholarly journals Obstructive sleep apnea syndrome in non-obese patients

2021 ◽  
Author(s):  
Caterina Antonaglia ◽  
Giovanna Passuti
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obese Patients ◽  
Obstructive Sleep ◽  
Obese Subjects ◽  
Apnea Syndrome ◽  
Symptoms And Signs

AbstractObstructive sleep apnea syndrome (OSAS) is characterized by symptoms and signs of more than 5 apneas per hour (AHI) at polysomnography or 15 or more apneas per hour without symptoms. In this review, the focus will be a subgroup of patients: adult non-obese subjects with OSA and their specific features. In non-obese OSA patients (patients with BMI < 30 kg/m2), there are specific polysomnographic features which reflect specific pathophysiological traits. Previous authors identified an anatomical factor (cranial anatomical factors, retrognatia, etc.) in OSA non-obese. We have hypothesized that in this subgroup of patients, there could be a non-anatomical pathological prevalent trait. Little evidence exists regarding the role of low arousal threshold. This factor could explain the difficulty in treating OSA in non-obese patients and emphasizes the importance of a specific therapeutic approach for each patient.

Pathogenetic Role of Increased Nasal Resistance in Obese Patients with Obstructive Sleep Apnea Syndrome

2010 ◽  
Vol 24 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Mitsuhiko Tagaya ◽  
Seiichi Nakata ◽  
Fumihiko Yasuma ◽  
Akiko Noda ◽  
Mami Morinaga ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Nasal Resistance ◽  
Obese Patients ◽  
Pathogenetic Role ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals The Role of Malocclusion in Non-obese Patients with Obstructive Sleep Apnea Syndrome

2008 ◽  
Vol 47 (18) ◽  
pp. 1573-1578 ◽  
Author(s):  
Etsuko Miyao ◽  
Akiko Noda ◽  
Masaru Miyao ◽  
Fumihiko Yasuma ◽  
Shigeru Inafuku
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obese Patients ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Periodic limb movements in patients with obstructive sleep apnea syndrome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaobo Zhou ◽  
Bo Zhou ◽  
Zhe Li ◽  
Qiao Lu ◽  
Shaoping Li ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Periodic Limb Movements ◽  
Limb Movements ◽  
Factors Associated ◽  
Obstructive Sleep ◽  
Apnea Syndrome

AbstractThe aim of the study was to assess the factors associated with periodic limb movements during sleep (PLMS) among obstructive sleep apnea syndrome (OSAS) patients and identify the role of PLMS in patients with OSAS. 303 adult patients with OSAS were included in the study. All patients completed physical examination, Epworth sleepiness scale (ESS), and polysomnography. Diagnosis of PLMS was made if the periodic leg movements index (PLMI) was ≥ 15. Chi-square test, ANOVA, univariate and multivariate logistic regression analyses were conducted to identify factors associated with PLMS among OSAS patients. Statistical analyses were performed with SPSS 26.0 for mac. Statistically significant difference was considered if P value < 0 .05. Among the 303 adult patients with OSAS, 98 patients had significant PLMS and the other 205 had no significant PLMS. Compared with OSAS patients without PLMS, OSAS patient with PLMS were older, had shorter REM duration and greater apnea–hypopnea index (AHI) (P < 0.05). The study suggests that PLMS is a matter of concern among patients with OSAS. A better understanding of the role of PLMS among OSAS patients could be useful in better recognition, intervention and treatment of OSAS.

scholarly journals Evaluation of endothelial function and cardiovascular risk in non-obese patients with slight degree of obstructive sleep apnea syndrome

2017 ◽  
Vol 87 (3) ◽  
Author(s):  
Fiorella Devito ◽  
Annapaola Zito ◽  
Silvano Dragonieri ◽  
Pierluigi Carratù ◽  
Vitaliano N. Quaranta ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cardiovascular Risk ◽  
Sleep Apnea ◽  
Endothelial Function ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Intima Media Thickness ◽  
Obese Patients ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Recently, it has been clearly described an independent relationship between obstructive sleep apnea syndrome (OSAS) and cardiovascular risk, with underlying mechanisms also including endothelial dysfunction. We enrolled 32 consecutive non-obese patients (mean age of 39.5±11.5 years), of which 16 with mild OSAS and 16 snoring without OSAS. Mild OSAS is defined by an AHI index between 5 and 15. We have investigated if whether there was a relationship between mild OSAS, endothelial function and carotid intima-media thickness (C-IMT). The population was divided into two groups: Group 1 (16 simple snorer patients with an average age of 39.4±12.1 years) and Group 2 (16 subjects with mild OSAS with an average age of 39.6±11.2 years). Each group underwent cardiovascular investigation including measurement of flow-mediated dilation (FMD) of the brachial artery and C-IMT. Both groups comprised non-obese subjects. Patients with mild OSAS had serum total cholesterol values statistically significantly higher than simple snores patients (178.6±24.9 vs 159.2±25.3; p=0.038). OSAS patients had also a trend towards higher values of maximum C-IMT compared to simple snorer patients (0.70±0.15 vs 0.65±0.16), although below the level of significance. Between the two groups, no difference was found for FMD values. The present results on mild OSAS strengthen the importance of a diagnosis of OSAS as soon as possible, in order to encourage all primary prevention interventions to correct risk factors responsible for disease progression and the occurrence of cardiovascular diseases, not excluding the use of therapies of non-invasive ventilation even in the early stages of the disease.

scholarly journals ROLE OF GABAERGIC SYSTEM GENETIC POLYMORPHISMS IN THE DEVELOPMENT OF OBSTRUCTIVE SLEEP APNEA SYNDROME IN ASTHMA PATIENTS

2019 ◽  
Vol 1 (71) ◽  
pp. 37-44
Author(s):  
Елизавета Шелудько ◽  
Elizaveta Shelud'ko ◽  
Денис Наумов ◽  
Denis Naumov ◽  
Дина Гассан ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Genetic Polymorphisms ◽  
Sleep Apnea Syndrome ◽  
Gabaergic System ◽  
Obstructive Sleep ◽  
Asthma Patients ◽  
Apnea Syndrome

The results of recent studies indicate the potential role of gamma-aminobutyric acid (GABA), as an inhibitory mediator of the central nervous system, in the pathogenesis of obstructive sleep apnea syndrome (OSAS) ‒ a common disorder that often accompanies asthma. The aim of the study was to investigate the possible role of some GABAergic system genetic polymorphisms in the formation of OSAS in asthma patients. Overnight cardiorespiratory monitoring was performed to diagnose OSAS and spirometry was conducted to evaluate the airway reactivity to the bronchodilator fenoterol in 184 asthma patients. Polymorphisms of GAD1, GAD2, GABBR1 and GABBR2 genes (15 polymorphisms in total) were genotyped by LATE-PCR method. Significant results were obtained for rs3749034 polymorphism of GAD1 gene and rs35400353 of GABBR2 in association analysis with the presence of OSAS. rs3749034 significantly influenced the presence of OSAS in males, which was accompanied by the predominance of the CC genotype among patients with OSAS, while CT+TT genotypes were more common in patients without OSAS (OR 3.9 95%CI [1.36–11.67], p=0.01). In total sample GAD1 rs3749034 polymorphism was an independent factor increasing the likelihood of having OSAS after adjustment for significant confounders (OR 1.9 95%CI [1.23–3.15], p=0.005). rs35400353 polymorphism was also associated with OSAS after adjustment for confounders, although its relationship was less significant (OR 1.5 95%CI [1.1–2.3], p=0.04). There was a tendency for interrelation with airway hyperresponsiveness to bronchodilator for both polymorphisms: rs3749034 ‒ in case of CT+TT genotypes, rs35400353 ‒ in case of DD genotype. rs3749034 polymorphism also significantly influenced lung function parameters. After additional verification of the results, the identified genetic polymorphisms may be used to individually predict the risk of OSAS as well as for the development of personalized approaches in asthma treatment using GABA.

Obstructive sleep apnea syndrome in non-severely obese patients with NAFLD

2014 ◽  
Vol 46 ◽  
pp. e55 ◽  
Author(s):  
E.A. Pulixi ◽  
S. Pelusi ◽  
E. Tobaldini ◽  
M. Bulgheroni ◽  
M. Pecis ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obese Patients ◽  
Obstructive Sleep ◽  
Severely Obese ◽  
Apnea Syndrome

scholarly journals Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0227834 ◽  
Author(s):  
Krisstopher Richard Flores ◽  
Fausta Viccaro ◽  
Mauro Aquilini ◽  
Stefania Scarpino ◽  
Francesco Ronchetti ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Neurotrophic Factor ◽  
Sleep Apnea Syndrome ◽  
Brain Derived Neurotrophic Factor ◽  
Protective Role ◽  
Obstructive Sleep ◽  
Apnea Syndrome
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