Application and validation of a biotic ligand model for calculating acute toxicity of lead to Moina dubia in lakes of Hanoi, Vietnam

Biotic ligand model (BLM) is a tool with the consideration of aquatic organism would have interaction with metals in different forms. Water chemical characteristics would also have some influence with bioavailability. In this study, BLM’s theoretical basis and realization process were discussed in detail, followed by the application status of the model. Finally, current challenges and future direction of BLM were pointed out. BLM assumes that the biological effect happens during the chemical equilibrium, which means that the model might only explain the acute toxicity results.

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Effects of water chemistry variables on gill binding and acute toxicity of cadmium in rainbow trout (Oncorhynchus mykiss): A biotic ligand model (BLM) approach

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology ◽

10.1016/j.cbpc.2008.05.015 ◽

2008 ◽

Vol 148 (4) ◽

pp. 305-314 ◽

Cited By ~ 17

Author(s):

Som Niyogi ◽

Rebecca Kent ◽

Chris M. Wood

Keyword(s):

Rainbow Trout ◽

Acute Toxicity ◽

Oncorhynchus Mykiss ◽

Water Chemistry ◽

Biotic Ligand Model ◽

Rainbow Trout Oncorhynchus Mykiss ◽

Biotic Ligand ◽

Ligand Model

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Extension of the biotic ligand model of acute toxicity to a physiologically-based model of the survival time of rainbow trout (Oncorhynchus mykiss) exposed to silver

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology ◽

10.1016/s1532-0456(02)00105-9 ◽

2002 ◽

Vol 133 (1-2) ◽

pp. 305-343 ◽

Cited By ~ 23

Author(s):

Paul R Paquin ◽

Viktoria Zoltay ◽

Richard P Winfield ◽

Kuen Benjamin Wu ◽

Rooni Mathew ◽

...

Keyword(s):

Rainbow Trout ◽

Acute Toxicity ◽

Oncorhynchus Mykiss ◽

Survival Time ◽

Biotic Ligand Model ◽

Rainbow Trout Oncorhynchus Mykiss ◽

Biotic Ligand ◽

Physiologically Based ◽

Physiologically Based Model ◽

Ligand Model

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Application of the biotic ligand model to predict copper acute toxicity to Medaka fish in typical Chinese rivers

Water Science & Technology ◽

10.2166/wst.2011.728 ◽

2011 ◽

Vol 64 (6) ◽

pp. 1277-1283 ◽

Cited By ~ 4

Author(s):

Chunyan Wang ◽

Hao Chen ◽

Kuen Benjamin Wu ◽

Lihui An ◽

Binghui Zheng

Keyword(s):

Acute Toxicity ◽

Surface Waters ◽

Water Samples ◽

Biotic Ligand Model ◽

Tidal River ◽

The Other ◽

Medaka Fish ◽

Cu Toxicity ◽

Biotic Ligand ◽

Ligand Model

LA50, the Lethal Accumulation of Cu on the Medaka fish (Oryzias latipes) gills that results in 50% mortality during a toxicological exposure (96 hours) in synthetic water was assessed by use of the biotic ligand model (BLM). The LA50 was employed to predict the 96 h Cu toxicity (LC50) to this fish in different natural surface waters in China. The LC50 values were predicted with errors of no more than 1.55 for the river water except for two water samples, one of which was from a tidal river and the other of which was from a river that was subject to joint metal pollution and possibly affected by other pollutants.

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