Necessary and sufficient checkpoint selection for temporal verification of high-confidence cloud workflow systems

2015 ◽  
Vol 58 (5) ◽  
pp. 1-16 ◽  
Author(s):  
FuTian Wang ◽  
Xiao Liu ◽  
Yun Yang
Keyword(s):  
High Confidence ◽  
Workflow Systems ◽  
Selection For ◽  
Necessary And Sufficient

Optical Filter Selection for High Confidence Discrimination of Strongly Overlapping Infrared Chemical Spectra

2015 ◽  
Vol 87 (17) ◽  
pp. 8798-8808 ◽  
Author(s):  
Kevin J. Major ◽  
Menelaos K. Poutous ◽  
Kenneth J. Ewing ◽  
Kevin F. Dunnill ◽  
Jasbinder S. Sanghera ◽  
...  
Keyword(s):  
Optical Filter ◽  
High Confidence ◽  
Selection For ◽  
Filter Selection

scholarly journals The NSL complex mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise

2018 ◽  
Author(s):  
Kin Chung Lam ◽  
Ho-Ryun Chung ◽  
Giuseppe Semplicio ◽  
Vivek Bhardwaj ◽  
Shantanu S. Iyer ◽  
...  
Keyword(s):  
Transcription Initiation ◽  
Dependent Manner ◽  
Gene Promoters ◽  
Transcription Start ◽  
Transcription Start Sites ◽  
Chromatin Remodeling Complex ◽  
Selection For ◽  
Necessary And Sufficient ◽  
Target Promoters ◽  
Active Genes

AbstractNucleosomal organization at gene promoters is critical for transcription, with a nucleosome-depleted region (NDR) at transcription start sites (TSSs) being required for transcription initiation. How NDR and the precise positioning of the +1 nucleosome is maintained on active genes remains unclear. Here, we report that the Drosophila Non-Specific Lethal (NSL) complex is necessary to maintain this stereotypical nucleosomal organization at promoters. Upon NSL1 depletion, nucleosomes invade the NDRs at TSSs of NSL-bound genes. NSL complex member NSL3 binds to TATA-less promoters in a sequence-dependent manner. The NSL complex interacts with the NURF chromatin remodeling complex and is necessary and sufficient to recruit NURF to target promoters. The NSL complex is not only essential for transcription but is required for accurate TSS selection for genes with multiple TSSs. Further, loss of NSL complex leads to an increase in transcriptional noise. Thus, the NSL complex establishes a canonical nucleosomal organization that enables transcription and determines TSS fidelity.

scholarly journals Human 5p-tailed Mirtrons are Processed by RNaseP

2021 ◽  
Author(s):  
M. Farid Zia ◽  
Jacob Peter ◽  
Johnathan Hoover ◽  
kuan-hui E Chen ◽  
Alex Sutton Flynt
Keyword(s):  
Human Genome ◽  
Splice Site ◽  
Strong Correlation ◽  
Sequence Motifs ◽  
Rna Turnover ◽  
High Confidence ◽  
Trna Processing ◽  
Canonical Pathways ◽  
Necessary And Sufficient ◽  
Hairpin Precursor

Approximately a thousand microRNAs (miRNAs) are documented from human cells. A third appear to transit non-canonical pathways that typically bypass processing by Drosha, the dedicated nuclear miRNA producing enzyme. The largest class of non-canonical miRNAs are mirtrons which eschew Drosha to mature through spliceosome activity. While mirtrons are found in several configurations, the vast majority of human mirtron species are 5p-tailed. For these mirtrons, a 3p splice site defines the 3p end of their hairpin precursor while a tail of variable length separates the 5p base of the hairpin from the nearest splice site. How this tail is removed is not understood. Here we examine sequence motifs in 5p-tailed mirtrons and interactions with RNA turnover processes to characterize biogenesis processes. Through studying the high confidence 5p-tailed mirtron, hsa-miR-5010, we identify RNaseP as necessary and sufficient for severing the 5p tail of this mirtron. Further, depletion of RNaseP activity globally decreased 5p-tailed mirtron expression implicating this endoribonuclease in biogenesis of the entire class. Moreover, as 5p-tailed mirtron biogenesis appears to be connected to tRNA processing we found a strong correlation between accumulation of tRNA fragments (tRFs) and 5p-tailed mirtron abundance. This suggests that dysregulation of tRNA processing seen in cancers may also impact expression of the ~400 5p-tailed mirtrons encoded in the human genome.

The extinction time of a general birth and death process with catastrophes

1986 ◽  
Vol 23 (04) ◽  
pp. 851-858 ◽  
Author(s):  
P. J. Brockwell
Keyword(s):  
Laplace Transform ◽  
Size Distribution ◽  
Sufficient Conditions ◽  
Necessary And Sufficient Conditions ◽  
Death Process ◽  
Extinction Time ◽  
Birth And Death Process ◽  
Different Types ◽  
The Laplace Transform ◽  
Necessary And Sufficient

The Laplace transform of the extinction time is determined for a general birth and death process with arbitrary catastrophe rate and catastrophe size distribution. It is assumed only that the birth rates satisfyλ0= 0,λj> 0 for eachj> 0, and. Necessary and sufficient conditions for certain extinction of the population are derived. The results are applied to the linear birth and death process (λj=jλ, µj=jμ) with catastrophes of several different types.

Framework for Selecting Vocabulary for Preliterate Children Who Use Augmentative and Alternative Communication

2019 ◽  
Vol 28 (3) ◽  
pp. 1000-1009
Author(s):  
Allison Bean ◽  
Lindsey Paden Cargill ◽  
Samantha Lyle
Keyword(s):  
Language Impairment ◽  
Augmentative And Alternative Communication ◽  
Developmentally Appropriate ◽  
School Age Children ◽  
Alternative Communication ◽  
School Based ◽  
Selection For ◽  
Nonverbal Children ◽  
Grammatical Structures ◽  
Insufficient Knowledge

Purpose Nearly 50% of school-based speech-language pathologists (SLPs) provide services to school-age children who use augmentative and alternative communication (AAC). However, many SLPs report having insufficient knowledge in the area of AAC implementation. The objective of this tutorial is to provide clinicians with a framework for supporting 1 area of AAC implementation: vocabulary selection for preliterate children who use AAC. Method This tutorial focuses on 4 variables that clinicians should consider when selecting vocabulary: (a) contexts/environments where the vocabulary can be used, (b) time span during which the vocabulary will be relevant, (c) whether the vocabulary can elicit and maintain interactions with other people, and (d) whether the vocabulary will facilitate developmentally appropriate grammatical structures. This tutorial focuses on the role that these variables play in language development in verbal children with typical development, verbal children with language impairment, and nonverbal children who use AAC. Results Use of the 4 variables highlighted above may help practicing SLPs select vocabulary that will best facilitate language acquisition in preliterate children who use AAC.

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