scholarly journals The novel H1N1 Influenza A global airline transmission and early warning without travel containments

2010 ◽  
Vol 55 (26) ◽  
pp. 3030-3036 ◽  
Author(s):  
ChaoYi Chang ◽  
ChunXiang Cao ◽  
Qiao Wang ◽  
Yu Chen ◽  
ZhiDong Cao ◽  
...  
Keyword(s):  
Early Warning ◽  
Influenza A ◽  
H1n1 Influenza ◽  
The Novel ◽  
Novel H1n1 Influenza

scholarly journals Update on Influenza Diagnostics: Lessons from the Novel H1N1 Influenza A Pandemic

2012 ◽  
Vol 25 (2) ◽  
pp. 344-361 ◽  
Author(s):  
S. Kumar ◽  
K. J. Henrickson
Keyword(s):  
Influenza A ◽  
H1n1 Influenza ◽  
The Novel ◽  
Novel H1n1 Influenza

scholarly journals Sequential Seasonal H1N1 Influenza Virus Infections Protect Ferrets against Novel 2009 H1N1 Influenza Virus

2012 ◽  
Vol 87 (3) ◽  
pp. 1400-1410 ◽  
Author(s):  
Donald M. Carter ◽  
Chalise E. Bloom ◽  
Eduardo J. M. Nascimento ◽  
Ernesto T. A. Marques ◽  
Jodi K. Craigo ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H1n1 Influenza ◽  
Cross Reactivity ◽  
Influenza Viruses ◽  
The Novel ◽  
Virus Infections ◽  
H1n1 Influenza Virus ◽  
Virus Shedding ◽  
2009 H1n1 ◽  
Novel H1n1 Influenza

ABSTRACTIndividuals <60 years of age had the lowest incidence of infection, with ∼25% of these people having preexisting, cross-reactive antibodies to novel 2009 H1N1 influenza. Many people >60 years old also had preexisting antibodies to novel H1N1. These observations are puzzling because the seasonal H1N1 viruses circulating during the last 60 years were not antigenically similar to novel H1N1. We therefore hypothesized that a sequence of exposures to antigenically different seasonal H1N1 viruses can elicit an antibody response that protects against novel 2009 H1N1. Ferrets were preinfected with seasonal H1N1 viruses and assessed for cross-reactive antibodies to novel H1N1. Serum from infected ferrets was assayed for cross-reactivity to both seasonal and novel 2009 H1N1 strains. These results were compared to those of ferrets that were sequentially infected with H1N1 viruses isolated prior to 1957 or more-recently isolated viruses. Following seroconversion, ferrets were challenged with novel H1N1 influenza virus and assessed for viral titers in the nasal wash, morbidity, and mortality. There was no hemagglutination inhibition (HAI) cross-reactivity in ferrets infected with any single seasonal H1N1 influenza viruses, with limited protection to challenge. However, sequential H1N1 influenza infections reduced the incidence of disease and elicited cross-reactive antibodies to novel H1N1 isolates. The amount and duration of virus shedding and the frequency of transmission following novel H1N1 challenge were reduced. Exposure to multiple seasonal H1N1 influenza viruses, and not to any single H1N1 influenza virus, elicits a breadth of antibodies that neutralize novel H1N1 even though the host was never exposed to the novel H1N1 influenza viruses.

Fulminant myocarditis associated with novel H1N1 influenza A

Heart & Lung ◽  
2011 ◽  
Vol 40 (6) ◽  
pp. 566-568 ◽  
Author(s):  
Rami N. Khouzam ◽  
Constantin Parizianu ◽  
Abdul Moiz Hafiz ◽  
Shalinee Chawla ◽  
Richard Schwartz
Keyword(s):  
Influenza A ◽  
H1n1 Influenza ◽  
Fulminant Myocarditis ◽  
Novel H1n1 Influenza

scholarly journals Asthma and severity of 2009 novel H1N1 influenza: a population-based case–control study

2013 ◽  
Vol 50 (10) ◽  
pp. 1069-1076 ◽  
Author(s):  
Carlos F. Santillan Salas ◽  
Sonia Mehra ◽  
Maria R. Pardo Crespo ◽  
Young J. Juhn
Keyword(s):  
Influenza A ◽  
Case Control Study ◽  
H1n1 Influenza ◽  
Population Based ◽  
Case Control ◽  
Novel H1n1 Influenza ◽  
Control Study

scholarly journals Mobile Pediatric Emergency Response Team: Patient Satisfaction During the Novel H1N1 Influenza Outbreak

2012 ◽  
Vol 19 (3) ◽  
pp. 274-279 ◽  
Author(s):  
Carla M. Laos ◽  
Michael C. DiStefano ◽  
Andrea T. Cruz ◽  
A. Chantal Caviness ◽  
Deborah C. Hsu ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Emergency Response ◽  
H1n1 Influenza ◽  
Pediatric Emergency ◽  
The Novel ◽  
Influenza Outbreak ◽  
Response Team ◽  
Novel H1n1 Influenza

scholarly journals Monoclonal Antibody Kit for Identification of the Novel 2009 H1N1 Influenza A Virus

2010 ◽  
Vol 48 (8) ◽  
pp. 2677-2682 ◽  
Author(s):  
A. D. Higgins ◽  
C. J. Shaw ◽  
J. G. Johnson ◽  
A. Navarro ◽  
N. A. Chapman ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Influenza A Virus ◽  
Influenza A ◽  
H1n1 Influenza ◽  
The Novel ◽  
2009 H1n1

Utility of Influenza Vaccination for Oncology Patients

2010 ◽  
Vol 28 (14) ◽  
pp. 2481-2490 ◽  
Author(s):  
Daniel A. Pollyea ◽  
Janice M.Y. Brown ◽  
Sandra J. Horning
Keyword(s):  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Hematologic Malignancies ◽  
H1n1 Influenza ◽  
The Novel ◽  
H1n1 Influenza Virus ◽  
Immunological Responses ◽  
Patients With Cancer ◽  
H1n1 Strain ◽  
Novel H1n1 Influenza

Every fall and winter, patients with cancer and their families ask oncologists whether they should be vaccinated for influenza. This season, with escalating concerns regarding the novel H1N1 influenza virus and its recently approved vaccine, this question has become more frequent and increasingly urgent. The purpose of this article is to review evidence related to the ability of patients with cancer to mount protective immunological responses to influenza vaccination. The literature on immunogenicity in pediatric and adult patients, those with solid tumors and hematologic malignancies, untreated and actively treated patients, and patients receiving biologic agents is summarized and reviewed. In addition, we report on potential strategies to improve the efficacy of influenza vaccination in patients with cancer, such as the timing of vaccination, use of more than a one-shot series, increasing the antigen dose, and the use of adjuvant therapies. We conclude that there is evidence that patients with cancer receiving chemotherapy are able to respond to influenza vaccination, and because this intervention is safe, inexpensive, and widely available, vaccination for seasonal influenza and the novel H1N1 strain is indicated.

Rationing of Resources: Ethical Issues in Disasters and Epidemic Situations

2009 ◽  
Vol 24 (3) ◽  
pp. 215-221 ◽  
Author(s):  
Janet Y. Lin ◽  
Lisa Anderson-Shaw
Keyword(s):  
Influenza A ◽  
Large Scale ◽  
Ethical Issues ◽  
H1n1 Influenza ◽  
Care Providers ◽  
Mechanical Ventilators ◽  
Ethical Decisions ◽  
Successful Recovery ◽  
1918 Influenza ◽  
Novel H1n1 Influenza

AbstractIn an epidemic situation or large-scale disaster, medical and human resources may be stretched to the point of exhaustion. Appropriate planning must incorporate plans of action that minimize public health morbidity and mortality while maximizing the appropriate use of medical and human healthcare resources. While the current novel H1N1 influenza has spread throughout the world, the severity of this strain of influenza appears to be relatively less virulent and lethal compared to the 1918 influenza pandemic.However, the presence of this new influenza strain has reignited interest in pandemic planning.Amongst other necessary resources needed to combat pandemic influenza, a major medical resource concern is the limited number of mechanical ventilators that would be available to be used to treat ill patients. Recent reported cases of avian influenza suggest that mechanical ventilation will be required for the successful recovery of many individuals ill with this strain of virus. However, should the need for ventilators exceed the number of available machines, how will care providers make the difficult ethical decisions as to who should be placed or who should remain on these machines as more influenza patients arrive in need of care?This paper presents a decision-making model for clinicians that is based upon the bioethical principles of beneficence and justice. The model begins with the basic assumptions of triage and progresses into a useful algorithm based upon utilitarian principles. The model is intended to be used as a guide for clinicians in making decisions about the allocation of scarce resources in a just manner and to serve as an impetus for institutions to create or adapt plans to address resource allocation issues should the need arise.

The Novel H1N1 Influenza

Science ◽  
2009 ◽  
Vol 326 (5960) ◽  
pp. 1607-1607 ◽  
Author(s):  
M. Enserink ◽  
J. Cohen
Keyword(s):  
H1n1 Influenza ◽  
The Novel ◽  
Novel H1n1 Influenza
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