This paper does some research on the mechanical property of multilayer container structure under high temperature and gives some suggestions on how to make fire protection based on the performance-based fire design. Firstly, using the software of FDS (Fire Dynamics Simulator), the fire background and fire heating release curve are determined. Through the simulation, the actual temperature curves (of the top and bottom temperature curves of the middle, door, and corner position in the container) are obtained and compared with the standard temperature curve of ISO-834. Secondly, using the software of Abaqus, a full scale finite element model of multilayer container structure is established. Two temperature fields under the standard temperature curve of ISO-834 and the actual temperature curve (of the most unfavorable curve of the top temperature curve of the middle position in the container) are obtained, respectively. Thirdly, the thermal-mechanical coupled analysis is carried out for the container structure under the wind loading and temperature field. The research result can be feasible in design and construction of container buildings and provides some references to corresponding specification preparation.