Combined treatment with parathyroid hormone (1–34) and beta-tricalcium phosphate had an additive effect on local bone formation in a rat defect model

2015 ◽  
Vol 54 (9) ◽  
pp. 1353-1362 ◽  
Author(s):  
Zhou-Shan Tao ◽  
Kai-kai Tu ◽  
Zheng-Liang Huang ◽  
Qiang Zhou ◽  
Tao Sun ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Formation ◽  
Tricalcium Phosphate ◽  
Combined Treatment ◽  
Additive Effect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
Local Bone

Bone formation in a rat calvarial defect model after transplanting autogenous bone marrow with beta-tricalcium phosphate

2010 ◽  
Vol 112 (3) ◽  
pp. 270-277 ◽  
Author(s):  
Nobuaki Shirasu ◽  
Takaaki Ueno ◽  
Yasuhisa Hirata ◽  
Azumi Hirata ◽  
Toshimasa Kagawa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Tricalcium Phosphate ◽  
Autogenous Bone ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
Rat Calvarial Defect

scholarly journals Fabrication and Evaluation of Porous Beta-Tricalcium Phosphate/Hydroxyapatite (60/40) Composite as a Bone Graft Extender Using Rat Calvarial Bone Defect Model

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jae Hyup Lee ◽  
Mi Young Ryu ◽  
Hae-Ri Baek ◽  
Kyung Mee Lee ◽  
Jun-Hyuk Seo ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Micro Ct ◽  
Porous Substrate ◽  
New Bone Formation ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
Bone Graft Extender

Beta-tricalcium phosphate (β-TCP) and hydroxyapatite (HA) are widely used as bone graft extenders due to their osteoconductivity and high bioactivity. This study aims to evaluate the possibility of using porous substrate with composite ceramics (β-TCP: HA = 60% : 40%, 60TCP40HA) as a bone graft extender and comparing it with Bio-Oss. Interconnectivity and macroporosity ofβ-TCP porous substrate were 99.9% and 83%, respectively, and the macro-porosity of packed granule after crushing was 69%. Calvarial defect model with 8 mm diameter was generated with male Sprague-Dawley rats and 60TCP40HA was implanted. Bio-Oss was implanted for a control group and micro-CT and histology were performed at 4 and 8 weeks after implantation. The 60TCP40HA group showed better new bone formation than the Bio-Oss group and the bone formation at central area of bone defect was increased at 8 weeks in micro-CT and histology. The percent bone volume and trabecular number of the 60TCP40HA group were significantly higher than those of Bio-Oss group. This study confirms the usefulness of the porous 60TCP40HA composite as a bone graft extender by showing increased new bone formation in the calvarial defect model and improved bone formation both quantitatively and qualitatively when compared to Bio-Oss.

Melatonin decorated 3D-printed beta-tricalcium phosphate scaffolds promoting bone regeneration in a rat calvarial defect model

2019 ◽  
Vol 7 (20) ◽  
pp. 3250-3259 ◽  
Author(s):  
Yali Miao ◽  
Yunhua Chen ◽  
Xiao Liu ◽  
Jingjing Diao ◽  
Naru Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
3D Printed ◽  
Rat Calvarial Defect

3D-printed β-TCP scaffolds decorated with melatonin via dopamine mussel-inspired chemistry enhance the osteogenesis and in vivo bone regeneration.

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