scholarly journals Beta‐tricalcium phosphate ceramic triggers fast and robust bone formation by human mesenchymal stem cells

2019 ◽  
Author(s):  
Rui C. Pereira ◽  
Roberto Benelli ◽  
Barbara Canciani ◽  
Monica Scaranari ◽  
Guy Daculsi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Formation ◽  
Tricalcium Phosphate ◽  
Human Mesenchymal Stem Cells ◽  
Beta Tricalcium Phosphate

IL-3 promotes osteoblast differentiation and bone formation in human mesenchymal stem cells

2012 ◽  
Vol 418 (4) ◽  
pp. 669-675 ◽  
Author(s):  
Amruta P. Barhanpurkar ◽  
Navita Gupta ◽  
Rupesh K. Srivastava ◽  
Geetanjali B. Tomar ◽  
Sameer P. Naik ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Formation ◽  
Osteoblast Differentiation ◽  
Human Mesenchymal Stem Cells

Histomorphometric Comparison of New Bone Formed After Maxillary Sinus Lift With Lateral and Crestal Approaches Using Periostal Mesenchymal Stem Cells and Beta-Tricalcium Phosphate

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Valentina Fatale ◽  
Stefano Pagnoni ◽  
Albino Emidio Pagnoni ◽  
Pier Carmine Passarelli ◽  
Andrea Netti ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Maxillary Sinus ◽  
Tricalcium Phosphate ◽  
Sinus Lift ◽  
Beta Tricalcium Phosphate

scholarly journals Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells

2009 ◽  
Vol 185 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Guizhong Liu ◽  
Sapna Vijayakumar ◽  
Luca Grumolato ◽  
Randy Arroyave ◽  
HuiFang Qiao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Formation ◽  
Wnt Signaling ◽  
De Novo ◽  
Human Mesenchymal Stem Cells ◽  
Mitogen Activated Protein Kinase ◽  
Bone Homeostasis

Genetic evidence indicates that Wnt signaling is critically involved in bone homeostasis. In this study, we investigated the functions of canonical Wnts on differentiation of adult multipotent human mesenchymal stem cells (hMSCs) in vitro and in vivo. We observe differential sensitivities of hMSCs to Wnt inhibition of osteogenesis versus adipogenesis, which favors osteoblastic commitment under binary in vitro differentiation conditions. Wnt inhibition of osteogenesis is associated with decreased expression of osteoblastic transcription factors and inhibition of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation, which are involved in osteogenic differentiation. An hMSC subpopulation exhibits high endogenous Wnt signaling, the inhibition of which enhances osteogenic and adipogenic differentiation in vitro. In an in vivo bone formation model, high levels of Wnt signaling inhibit de novo bone formation by hMSCs. However, hMSCs with exogenous expression of Wnt1 but not stabilized β-catenin markedly stimulate bone formation by naive hMSCs, arguing for an important role of a canonical Wnt gradient in hMSC osteogenesis in vivo.

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