Responsiveness to hormone, growth factor and drug treatment of a human breast cancer cell line: Comparison between early and late cultures

1998 ◽  
Vol 34 (10) ◽  
pp. 836-843 ◽  
Author(s):  
Alessandra de Cupis ◽  
Paolo Pirani ◽  
Laura Fazzuoli ◽  
Roberto E. Favoni
2003 ◽  
Vol 278 (44) ◽  
pp. 43363-43372 ◽  
Author(s):  
Jun Kawagoe ◽  
Masahide Ohmichi ◽  
Toshifumi Takahashi ◽  
Chika Ohshima ◽  
Seiji Mabuchi ◽  
...  

2002 ◽  
Vol 129 (1-2) ◽  
pp. 55-63 ◽  
Author(s):  
Christel M Olsen ◽  
Elise T.M Meussen-Elholm ◽  
Jørn A Holme ◽  
Jan K Hongslo

2021 ◽  
Vol 66 (1) ◽  
pp. 65-71
Author(s):  
Hung Nguyen Phi ◽  
Toan Tran Quoc ◽  
Tuan Nguyen Anh ◽  
Vy Trinh Ngoc Thao ◽  
Yen Ngo Thi Ngoc ◽  
...  

Three alkaloids (named rutaecarpine (1), evodiamine (2), schinifoline (3) and one phenylpropanoid, integrifoliodiol (4)) have been isolated from the EtOAc extract of the fruits of Tetradium ruticarpum (A. Juss.) T. G. Hartley collected in Lang Son province. Their structures have been identified by using 1D and 2D NMR spectroscopies. All four compounds were tested for their cytotoxicity against the human breast cancer cell line (MCF-7) and tamoxifen-resistant breast cancer cell line (MCF\TAMR). The results showed that rutaecarpine (1) inhibited the growth of MCF7 and MCF\TAMR with its IC50 values of 41.2 and 64.6 µM, respectively. In addition, compounds 1, 2, and 4 showed moderate activity toward MCF-7 cell line.


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