The principal aim of this paper is to determine the reasonable design parameters of high-speed railway vibration attenuation. The orthogonal test method is used to design the test of ground vibration induced by high-speed train. Four main factors that impact the maximum ground vertical vibration level are selected, and different values are given to each factor, so 8 groups of combinations can be obtained by using orthogonal test technique. Each group test data of the maximum ground vertical vibration level can be obtained by conducting vehicle testing on-track. In this paper, the primary and secondary factors that impact the maximum ground vertical vibration level are determined by range analysis. Moreover, the neural network theory is used to establish a model of the ground vertical vibration level, and this model can be trained and verified by the test data. The impact factors can be predicted by the method of combining orthogonal test and neural network concerning the specified vibration limit, and the value of maximum ground vertical vibration level with the predicted factors meets the requirement of accuracy. The conclusions provide a valuable reference to the vibration attenuation design of the high-speed railway.