Background:
Development of controlled drug delivery systems can improve the pharmacokinetic characteristics
of drug molecules in the human body, thereby significantly improving the utilization rate of drugs and reducing toxicity and
side effects caused by high concentrations of drugs, which can occur when delivery is not controlled. Metal organic frameworks are a new class of very promising crystalline microporous materials, especially when the size is reduced to the nanometer range. Metal organic frameworks exhibit large specific surface areas, tunable compositions, and easy functionalization. In recent years, increasing number of studies have reported the remarkable advances in multifunctional nanoscale metal
organic frameworks in drug delivery.
Objective:
Review the latest research involving advances in stimuli-responsive nanoscale metal organic frameworks as drug
delivery systems in controlled-release drugs.
Discussion:
We first introduce the two main strategies associated with nanoscale metal organic frameworks used in drug
loading: direct assembly and post-encapsulation. We next focus on the latest discoveries of nanoscale metal organic framework-based stimulus response systems for drug delivery, including pH, magnetics, light, ion, temperature, and other stimuli,
as well as multiple stimulus-responsive drug delivery systems. Finally, we discuss the challenges and future development directions of nanoscale metal organic framework-based controlled drug release.
Advances in Functional Metal‐Organic Frameworks Based On‐Demand Drug Delivery Systems for Tumor Therapeutics
