Evaluation of systo-diastolic cardiac function and arterial stiffness in subjects with new diagnosis of coeliac disease without cardiovascular risk factors

AbstractRecent evidence suggests that cellular perturbations play an important role in the pathogenesis of cardiovascular diseases. Therefore, we analyzed the association between the levels of urinary metabolites and arterial stiffness. Our cross-sectional study included 330 Korean men and women. The brachial-ankle pulse wave velocity was measured as a marker of arterial stiffness. Urinary metabolites were evaluated using a high-performance liquid chromatograph-mass spectrometer. The brachial-ankle pulse wave velocity was found to be positively correlated with l-lactate, citrate, isocitrate, succinate, malate, hydroxymethylglutarate, α-ketoisovalerate, α-keto-β-methylvalerate, methylmalonate, and formiminoglutamate among men. Whereas, among women, the brachial-ankle pulse wave velocity was positively correlated with cis-aconitate, isocitrate, hydroxymethylglutarate, and formiminoglutamate. In the multivariable regression models adjusted for conventional cardiovascular risk factors, three metabolite concentrations (urine isocitrate, hydroxymethylglutarate, and formiminoglutamate) were independently and positively associated with brachial-ankle pulse wave velocity. Increased urine isocitrate, hydroxymethylglutarate, and formiminoglutamate concentrations were associated with brachial-ankle pulse wave velocity and independent of conventional cardiovascular risk factors. Our findings suggest that metabolic disturbances in cells may be related to arterial stiffness.

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FRI0170 Cardiovascular risk factors and disease characteristics are consistently associated with arterial stiffness in rheumatoid arthritis

10.1136/annrheumdis-2017-eular.4277 ◽

2017 ◽

Author(s):

S Gunter ◽

C Robinson ◽

G Norton ◽

A Woodiwiss ◽

L Tsang ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Cardiovascular Risk ◽

Arterial Stiffness ◽

Cardiovascular Risk Factors ◽

Disease Characteristics

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Association of arterial wall stiffness with cardiovascular risk factors

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2009-15-3-290-295 ◽

2009 ◽

Vol 15 (3) ◽

pp. 290-295 ◽

Cited By ~ 2

Author(s):

V. V. Ivanenko ◽

O. P. Rotar ◽

A. Konradi

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Cardiovascular Risk ◽

Arterial Stiffness ◽

Cardiovascular Risk Factors ◽

Cholesterol Level ◽

Augmentation Index ◽

Central Blood Pressure ◽

Blood Pressure Elevation ◽

Wall Stiffness

Objective. To assess relation between central blood pressure and arterial stiffness with cardiovascular risk factors. Design and methods. 116 subjects considering themselves healthy were examined. 63 showed blood pressure elevation. Anthropometry was performed and fasting blood specimens were obtained from all patients. Plasma glucose and lipids levels were measured. Pulse wave velocity (PWV) and augmentation index (AI) were measured by Sphygmocor Px device (Australia). Results. Parameters of arterial stiffness were strongly associated with hypertension, increased waist circumference, age, cholesterol level, and metaboloc syndrome. Females had higher AI as compared to males. Conclusion. Central blood pressure and arterial stiffness are determined not only by age and peripheral blood pressure but by cholesterol level and anthropometric parameters as well.

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Review: Pulse pressure, arterial stiffness and wave reflections (augmentation index) as cardiovascular risk factors in hypertension

Therapeutic Advances in Cardiovascular Disease ◽

10.1177/1753944707086652 ◽

2008 ◽

Vol 2 (1) ◽

pp. 13-24 ◽

Cited By ~ 34

Author(s):

Michel E. Safar

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Arterial Stiffness ◽

Cardiovascular Risk Factors ◽

Pulse Pressure ◽

Augmentation Index ◽

Wave Reflections

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Thyroid dysfunction and cardiovascular risk factors in Bulgarian adults

Open Medicine ◽

10.2478/s11536-013-0235-9 ◽

2013 ◽

Vol 8 (6) ◽

pp. 742-748 ◽

Cited By ~ 1

Author(s):

Alexander Shinkov ◽

Anna-Maria Borissova ◽

Roussanka Kovatcheva ◽

Jordan Vlahov ◽

Lilia Dakovska ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Arterial Hypertension ◽

Cardiovascular Risk Factors ◽

Thyroid Function ◽

Thyroid Dysfunction ◽

Lipid Status ◽

Arterial Blood ◽

Bulgarian Population ◽

New Diagnosis

AbstractThe aim of this study was to determine the prevalence of thyroid dysfunction and its association with cardiovascular risk factors in an adult Bulgarian population. 2402 subjects were studied, 1347 female, 20–94y (median: 48.0y) and 1055 male, 20–91y (median: 45.5y). Body weight, height, waist circumference, arterial blood pressure, TSH, FT4 and lipids were measured. Known hypothyroidism was reported by 53 subjects (2.2%) and hyperthyroidism by 20 (0.8%). New hypothyroidism was found in 98 (4.1%), [subclinical (3.2%), overt (0.9%)]. New hyperthyroidism was found in 68 (2.9%), [subclinical (2.5%), overt (0.4%)]. New diagnosis of hypothyroidism and hyperthyroidism was entered in 84% and 87% in male subjects and 60% and 65% in the females respectively. Arterial hypertension was present in 40% of the women and in 47% of the men (p<0.001) and was more prevalent in hypothyroidism. Abdominal obesity and dyslipidemia were more prevalent in males and hypothyroid subjects. Arterial hypertension depended on age, gender and lipid status but not on thyroid function. CHD history depended on thyroid function and age. Conclusion: Most cases of thyroid dysfunction were undiagnosed, especially in the males. CV risk factors were more prevalent in the males with thyroid dysfunction a major determinant of CHD, but not hypertension.

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