An optical sensor for hydrogen sulfide detection in open path using WMS-2f/1f technique

2016 ◽  
Vol 12 (6) ◽  
pp. 465-468 ◽  
Author(s):  
Li-mei Song ◽  
Li-wen Liu ◽  
Yan-gang Yang ◽  
Qing-hua Guo ◽  
Jiang-tao Xi
Keyword(s):  
Hydrogen Sulfide ◽  
Optical Sensor ◽  
Open Path

Active silica-gel films for hydrogen sulfide optical sensor application

1994 ◽  
Vol 19 (14) ◽  
pp. 1085 ◽  
Author(s):  
M. R. Shahriari ◽  
J. Ding
Keyword(s):  
Hydrogen Sulfide ◽  
Silica Gel ◽  
Optical Sensor ◽  
Sensor Application

Towards laser-based open-path detection of hydrogen sulfide

2016 ◽  
Author(s):  
Michal Nikodem ◽  
Dorota Stachowiak ◽  
Piotr Jaworski
Keyword(s):  
Hydrogen Sulfide ◽  
Open Path ◽  
Path Detection

Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation

2019 ◽  
Vol 133 (20) ◽  
pp. 2045-2059 ◽  
Author(s):  
Da Zhang ◽  
Xiuli Wang ◽  
Siyao Chen ◽  
Selena Chen ◽  
Wen Yu ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Endothelial Cell ◽  
Pulmonary Artery ◽  
Cell Model ◽  
Site Directed Mutagenesis ◽  
Critical Event ◽  
Hypertensive Rats ◽  
Pulmonary Artery Endothelial Cell

Abstract Background: Pulmonary artery endothelial cell (PAEC) inflammation is a critical event in the development of pulmonary arterial hypertension (PAH). However, the pathogenesis of PAEC inflammation remains unclear. Methods: Purified recombinant human inhibitor of κB kinase subunit β (IKKβ) protein, human PAECs and monocrotaline-induced pulmonary hypertensive rats were employed in the study. Site-directed mutagenesis, gene knockdown or overexpression were conducted to manipulate the expression or activity of a target protein. Results: We showed that hydrogen sulfide (H2S) inhibited IKKβ activation in the cell model of human PAEC inflammation induced by monocrotaline pyrrole-stimulation or knockdown of cystathionine γ-lyase (CSE), an H2S generating enzyme. Mechanistically, H2S was proved to inhibit IKKβ activity directly via sulfhydrating IKKβ at cysteinyl residue 179 (C179) in purified recombinant IKKβ protein in vitro, whereas thiol reductant dithiothreitol (DTT) reversed H2S-induced IKKβ inactivation. Furthermore, to demonstrate the significance of IKKβ sulfhydration by H2S in the development of PAEC inflammation, we mutated C179 to serine (C179S) in IKKβ. In purified IKKβ protein, C179S mutation of IKKβ abolished H2S-induced IKKβ sulfhydration and the subsequent IKKβ inactivation. In human PAECs, C179S mutation of IKKβ blocked H2S-inhibited IKKβ activation and PAEC inflammatory response. In pulmonary hypertensive rats, C179S mutation of IKKβ abolished the inhibitory effect of H2S on IKKβ activation and pulmonary vascular inflammation and remodeling. Conclusion: Collectively, our in vivo and in vitro findings demonstrated, for the first time, that endogenous H2S directly inactivated IKKβ via sulfhydrating IKKβ at Cys179 to inhibit nuclear factor-κB (NF-κB) pathway activation and thereby control PAEC inflammation in PAH.

Workload Perception of Air Traffic Control Officers and Pilots During Continuous Descent Operations Approach Procedures

2019 ◽  
Vol 9 (1) ◽  
pp. 2-11
Author(s):  
Marina Efthymiou ◽  
Frank Fichert ◽  
Olaf Lantzsch
Keyword(s):  
Fuel Consumption ◽  
Traffic Control ◽  
Air Traffic Control ◽  
Negative Impact ◽  
Air Traffic ◽  
Reduce Fuel Consumption ◽  
Total Load ◽  
Open Path

Abstract. The paper examines the workload perceived by air traffic control officers (ATCOs) and pilots during continuous descent operations (CDOs), applying closed- and open-path procedures. CDOs reduce fuel consumption and noise emissions. Therefore, they are supported by airports as well as airlines. However, their use often depends on pilots asking for CDOs and controllers giving approval and directions. An adapted NASA Total Load Index (TLX) was used to measure the workload perception of ATCOs and pilots when applying CDOs at selected European airports. The main finding is that ATCOs’ workload increased when giving both closed- and open-path CDOs, which may have a negative impact on their willingness to apply CDOs. The main problem reported by pilots was insufficient distance-to-go information provided by ATCOs. The workload change is important when considering the use of CDOs.

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