Homogenized Macroscale Model and Morphological Microscale Model to Understand the Varying Mechanical Properties of Scar Tissue of Hip Capsule Ligaments Grown Around Different Implant Materials

JOM ◽  
2021 ◽  
Author(s):  
Angelina Avgeri ◽  
Samantha Sanders ◽  
Bertrand Cinquin ◽  
Laurent Sedel ◽  
Pascal Bizot ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Scar Tissue ◽  
Implant Materials ◽  
Microscale Model ◽  
Hip Capsule

Cytocompatibility and Material Properties of Poly-carbonate Urethane/Carbon Nanofiber Composites for Neural Applications

2003 ◽  
Vol 774 ◽  
Author(s):  
Janice L. McKenzie ◽  
Michael C. Waid ◽  
Riyi Shi ◽  
Thomas J. Webster
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanofibers ◽  
Material Properties ◽  
Carbon Nanofiber ◽  
Scar Tissue ◽  
Tissue Response ◽  
Positive Interactions ◽  
Weight Percentage ◽  
Poly Carbonate

AbstractCarbon nanofibers possess excellent conductivity properties, which may be beneficial in the design of more effective neural prostheses, however, limited evidence on their cytocompatibility properties exists. The objective of the present in vitro study was to determine cytocompatibility and material properties of formulations containing carbon nanofibers to predict the gliotic scar tissue response. Poly-carbonate urethane was combined with carbon nanofibers in varying weight percentages to provide a supportive matrix with beneficial bulk electrical and mechanical properties. The substrates were tested for mechanical properties and conductivity. Astrocytes (glial scar tissue-forming cells) were seeded onto the substrates for adhesion. Results provided the first evidence that astrocytes preferentially adhered to the composite material that contained the lowest weight percentage of carbon nanofibers. Positive interactions with neurons, and, at the same time, limited astrocyte functions leading to decreased gliotic scar tissue formation are essential for increased neuronal implant efficacy.

scholarly journals Characterization of scar tissue biomechanics during adult murine flexor tendon healing

2021 ◽  
Author(s):  
Antonion Korcari ◽  
Alayna E Loiselle ◽  
Mark R Buckley
Keyword(s):  
Mechanical Properties ◽  
Material Properties ◽  
Healing Process ◽  
Tendon Healing ◽  
Scar Tissue ◽  
Element Analysis ◽  
Material Quality ◽  
Treatment Regimens ◽  
Tangent Moduli ◽  
Experimental Findings

Tendon injuries are very common and result in significant impairments in mobility and quality of life. During healing, tendons produce a scar at the injury site, characterized by abundant and disorganized extracellular matrix and by permanent deficits in mechanical integrity compared to healthy tendon. Although a significant amount of work has been done to understand the healing process of tendons and to develop potential therapeutics for tendon regeneration, there is still a significant gap in terms of assessing the direct effects of therapeutics on the functional and material quality specifically of the scar tissue, and thus, on the overall tendon healing process. In this study, we focused on characterizing the mechanical properties of only the scar tissue in flexor digitorum longus (FDL) tendons during the proliferative and remodeling healing phases and comparing these properties with the mechanical properties of the composite healing tissue. Our method was sensitive enough to identify significant differences in structural and material properties between the scar and tendon-scar composite tissues. To account for possible inaccuracies due to the small aspect ratio of scar tissue, we also applied inverse finite element analysis (iFEA) to compute mechanical properties based on simulated tests with accurate specimen geometries and boundary conditions. We found that the scar tissue linear tangent moduli calculated from iFEA were not significantly different from those calculated experimentally at all healing timepoints, validating our experimental findings, and suggesting the assumptions in our experimental calculations were accurate. Taken together, this study first demonstrates that due to the presence of uninjured stubs, testing composite healing tendons without isolating the scar tissue overestimates the material properties of the scar itself. Second, our scar isolation method promises to enable more direct assessment of how different treatment regimens (e.g., cellular ablation, biomechanical and/or biochemical stimuli, tissue engineered scaffolds) affect scar tissue function and material quality in multiple different types of tendons.

scholarly journals Mechanical Properties of Hip Capsule Tissue After a Hip Arthroplasty

2021 ◽  
Author(s):  
A. Avgeri ◽  
B. Cinquin ◽  
L. Sedel ◽  
P. Bizot ◽  
S. Sanders ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Hip Arthroplasty ◽  
Hip Capsule

Mechanical properties and biological behavior of carbon nanotube/polycarbosilane composites for implant materials

2007 ◽  
Vol 82B (1) ◽  
pp. 223-230 ◽  
Author(s):  
Wei Wang ◽  
Fumio Watari ◽  
Mamoru Omori ◽  
Susan Liao ◽  
Yuhe Zhu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotube ◽  
Biological Behavior ◽  
Implant Materials

Mechanical properties of urogynecologic implant materials

2003 ◽  
Vol 14 (4) ◽  
pp. 239-243 ◽  
Author(s):  
H. P. Dietz ◽  
P. Vancaillie ◽  
M. Svehla ◽  
W. Walsh ◽  
A. B. Steensma ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Implant Materials

The mechanical properties of the human hip capsule ligaments

2002 ◽  
Vol 17 (1) ◽  
pp. 82-89 ◽  
Author(s):  
John D. Hewitt ◽  
Richard R. Glisson ◽  
Farshid Guilak ◽  
T.Parker Vail
Keyword(s):  
Mechanical Properties ◽  
Hip Capsule
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