scholarly journals Do Genetic Variants of the Renin-Angiotensin System Predict Blood Pressure Response to Renin-Angiotensin System–Blocking Drugs? A Systematic Review of Pharmacogenomics in the Renin-Angiotensin System

2011 ◽  
Vol 13 (5) ◽  
pp. 356-361 ◽  
Author(s):  
Tadashi Konoshita ◽  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Genetic Variants ◽  
Blood Pressure Response ◽  
Renin Angiotensin System ◽  
Pressure Response ◽  
Angiotensin System ◽  
Renin Angiotensin

Relationship of blood pressure response and the renin-angiotensin system to first-dose prazosin

1985 ◽  
Vol 78 (2) ◽  
pp. 241-244 ◽  
Author(s):  
John P. Nicholson ◽  
Lawrence M. Resnick ◽  
Thomas G. Pickering ◽  
Rosemerie Marion ◽  
Patricia Sullivan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Response ◽  
Renin Angiotensin System ◽  
Pressure Response ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Relationship Of

Brain renin-angiotensin system modifies the blood pressure response to intracerebroventricular cadmium in rats

2010 ◽  
Vol 33 (3) ◽  
pp. 302-309 ◽  
Author(s):  
Maria V. Varoni ◽  
Domenico Palomba ◽  
Nicolò P. Macciotta ◽  
Elisabetta Antuofermo ◽  
Graziella Deiana ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Response ◽  
Renin Angiotensin System ◽  
Pressure Response ◽  
Angiotensin System ◽  
Renin Angiotensin

Exaggerated blood pressure response to angiotensin II in patients with Cushing's syndrome due to adrenocortical adenoma

1994 ◽  
Vol 131 (6) ◽  
pp. 582-588 ◽  
Author(s):  
Gen Yasuda ◽  
Hiroshi Shionoiri ◽  
Satoshi Umemura ◽  
Izumi Takasaki ◽  
Masao Ishii
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Cushing’S Syndrome ◽  
Blood Pressure Response ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Cushing's Syndrome ◽  
Adrenocortical Adenoma ◽  
Angiotensin System ◽  
Renin Angiotensin

Yasuda G, Shionoiri H, Umemura S, Takasaki I, Ishii M. Exaggerated blood pressure response to angiotensin II in patients with Cushing's syndrome due to adrenocortical adenoma. Eur J Endocrinol 1994:131:582–8 ISSN 0804–4643 We studied the roles played by the renin-angiotensin system in inducing hypertension in nine patients with Cushing's syndrome (CS) resulting from adrenocortical adenoma, and compared them with those in patients with primary aldosteronism (PA), renovascular hypertension (RVH) and essential hypertension (EH). In the CS group, each parameter, including serum potassium, plasma renin activity, plasma aldosterone, deoxycorticosterone and corticosterone concentrations, is within the normal range. However, plasma renin activity in the CS group was lower than that in the RVH group but higher than that in the PA group, and plasma aldosterone concentration was lower than that in each RVH or PA group. These findings indicated that the CS group had a different type of hypertension from that in either RVH or PA, in which the renin angiotensin system or mineralocorticoids play an important role in hypertension. Meanwhile, captopril (50 mg) administration either with or without indomethacin pretreatment decreased the mean blood pressure in the CS group, although captopril failed to change it in the PA group or in normal subjects. Furthermore, the pressor response to exogenous angiotensin II in the CS group was higher than that in the RVH or EH group, but was not different from that in the PA group. Thus, the hypertension in patients with CS due to adrenocortical adenoma appears to be mediated through a change in the renin-angiotensin system in the form of exaggerated pressor responses to angiotensin II. G Yasuda, Second Department of Internal Medicine, Yokohama City University School of Medicine, 3-46 Urafune, Minami, Yokohama 232, Japan

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