scholarly journals Genetic Variant of the Renin-Angiotensin System and Diabetes Influences Blood Pressure Response to Angiotensin Receptor Blockers

Diabetes Care ◽  
2009 ◽  
Vol 32 (8) ◽  
pp. 1485-1490 ◽  
Author(s):  
T. Konoshita ◽  
N. Kato ◽  
S. Fuchs ◽  
S. Mizuno ◽  
C. Aoyama ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Genetic Variant ◽  
Blood Pressure Response ◽  
Angiotensin Receptor Blockers ◽  
Renin Angiotensin System ◽  
Pressure Response ◽  
Angiotensin Receptor ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Receptor Blockers

scholarly journals Genetic Variants of C-5312TRENIncreased Renin Levels and Diastolic Blood Pressure Response to Angiotensin Receptor Blockers

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Mohammad Saifur Rohman ◽  
Ika Arum Dewi Satiti ◽  
Nashi Widodo ◽  
Mifetika Lukitasari ◽  
Hidayat Sujuti
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Diastolic Pressure ◽  
Blood Pressure Response ◽  
Angiotensin Receptor Blockers ◽  
Pressure Response ◽  
Angiotensin Receptor ◽  
Hypertensive Patients ◽  
Renin Level ◽  
Receptor Blockers

Renin catalyzes the cleavage of angiotensinogen into angiotensin I. Genetic variant C-5312T of renin enhancer has been reported to increase in vitro renin gene transcription. However, no obvious in vivo study was performed to see the renin level in C-5312T when treated with angiotensin receptor blockers (ARB). Therefore, this study aimed to investigate the serum renin level and blood pressure response in ARB treated hypertensive patients. Single nucleotide polymorphism (SNP) of C-5312T was identified in 55 hypertensive patients by using multiplex PCR and renin serum level was assayed by ELISA. The data showed that the increase of serum renin levels after 5 months of ARB treatment was significantly higher in patients with CT/TT genotype (10 pg/mL) than those with CC genotype (4.08 pg/mL) (P= 0.025). Hypertensive patients with CT/TT genotypes also showed less diastolic pressure reduction than CC genotypes in hypertensive patients with valsartan treatment (P= 0.04) or telmisartan treatment (P= 0.03). Finally, these findings suggested that SNP of C-5312TRENenhancer might contribute to higher increased renin serum levels and less diastolic blood pressure response to ARB treatment.

scholarly journals Renin-Angiotensin-System (RAS) und COVID-19 – Zur Verordnung von RAS-Blockern

2020 ◽  
Vol 145 (10) ◽  
pp. 682-686 ◽  
Author(s):  
Reinhold Kreutz ◽  
Engi Abd El-Hady Algharably ◽  
Detlev Ganten ◽  
Franz Messerli
Keyword(s):  
Angiotensin Receptor Blockers ◽  
Renin Angiotensin System ◽  
Short Review ◽  
Angiotensin Receptor ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Analysis And Evaluation ◽  
Receptor Blockers ◽  
Ras Blockers ◽  
Regulatory Functions

AbstractTwenty years ago, an enzyme homologous to the previously known angiotensin-converting enzyme (ACE) was identified, and subsequently named ACE2. In the renin-angiotensin system (RAS), ACE2 has counter-regulatory functions against the classical effector peptide angiotensin II, for example in blood pressure regulation and cardiovascular remodeling. However, ACE2 provides an initially unexpected interesting link between virology and cardiovascular medicine. That is, ACE2 represents the binding receptor for the cellular uptake of SARS-CoV and SARS-CoV-2 viruses. Thus, ACE2 is relevant for COVID-19. In this context, it was suspected that therapy with RAS blockers might promote transmission and complications of COVID-19 by upregulation of ACE2 expression. The aim of this short review is, to describe the link between the RAS, particularly ACE2, and COVID-19. Based on our analysis and evaluation of the available findings, we justify our conclusion: important drugs such as ACE inhibitors and angiotensin receptor blockers should continue to be prescribed according to guidelines to stable patients in the context of the COVID-19 pandemic.

Relationship of blood pressure response and the renin-angiotensin system to first-dose prazosin

1985 ◽  
Vol 78 (2) ◽  
pp. 241-244 ◽  
Author(s):  
John P. Nicholson ◽  
Lawrence M. Resnick ◽  
Thomas G. Pickering ◽  
Rosemerie Marion ◽  
Patricia Sullivan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Response ◽  
Renin Angiotensin System ◽  
Pressure Response ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Relationship Of
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