Central Retinal Vein Occlusion Secondary to Protein S Deficiency

2007 ◽  
Vol 39 (4) ◽  
pp. 343-344 ◽  
Author(s):  
Yew Chong Yap ◽  
Faye Barampouti
Keyword(s):  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Protein S ◽  
Protein S Deficiency ◽  
Vein Occlusion ◽  
S Deficiency ◽  
Central Retinal Vein

Central retinal vein occlusion as a presenting feature in a young patient with protein S deficiency

2014 ◽  
Vol 98 (2) ◽  
pp. 190-191
Author(s):  
Rupak Roy ◽  
Kumar Saurabh ◽  
Amit B Jain ◽  
Debmalya Das ◽  
Anindya K Majumder ◽  
...  
Keyword(s):  
Young Patient ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Protein S ◽  
Protein S Deficiency ◽  
Vein Occlusion ◽  
S Deficiency ◽  
Central Retinal Vein

Thrombophilia as a Risk Factor for Central Retinal Vein Thrombosis.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 5054-5054
Author(s):  
Fotios I Girtovitis ◽  
Elisabet Tsakiroglou ◽  
Michael D. Diamantidis ◽  
Zoi Saouli ◽  
Zisis Kontoninas ◽  
...  
Keyword(s):  
Risk Factor ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Protein C ◽  
Factor V Leiden ◽  
Protein S ◽  
Factor V ◽  
Vein Thrombosis ◽  
Vein Occlusion ◽  
Central Retinal Vein

Abstract Abstract 5054 Introduction An increased risk of central retinal vein occlusion in patients with hypertension, hypercholesterolemia and diabetes mellitus has been recently shown. However, controversial literature results have failed to establish an association between central retinal vein occlusion and thrombophilic abnormalities. Aim To investigate thrombophilic factors in patients with central retinal vein thrombosis. Material and Methods 20 patients with a median age of 48±13 yrs [7 males (median age 53,2±8,4 yrs) and 13 females (median age 48,1±17,7 yrs)], who presented in the Hemostasis Unit of the First Propedeutic Department of Internal Medicine of AHEPA hospital during the last two years, were studied. All the patients suffered from central retinal vein thrombosis, which was diagnosed by fluorescein angiography. Detailed evaluation of the coagulation mechanism included examination of fibrinogen, d-dimers, thrombin time, reptilase time, protein C, protein S, antithrombin III, activated protein C resistance, factor V-Leiden and prothrombin G20210A mutation, homocystein, II, V, VII, VIII, IX, X, XI and XII coagulation factors, anti-cardiolipin antibodies, lupus anticoagulants and anti-β2 glycoprotein I. Moreover, factors of increased cardiovascular risk (obesity, hypertension, diabetes, smoking, hyperlipidemia) were studied. Results 3 male and 4 female patients suffered from antiphospholipid syndrome (APS) (5 had primary APS, 1 female had secondary APS due to systemic lupus erythematosus, while another female was diagnosed with both APS and thrombophilia Leiden). 5 patients (4 female καı 1 male) were heterozygotes for factor V-Leiden mutation. From these 5 patients, 2 were obese and had hypertension, 1 female had been receiving contraceptives, 1 other female had additionally increased levels of factor VIII (240%), whereas the fourth female suffered from additional protein S deficiency (41%). Interestingly, 4 female patients (4/20, 20%) were found to be double heterozygotes (factor V-Leiden and prothrombin mutation). In 3 females (1 of whom had a history of pulmonary embolism), the whole laboratory investigation for thrombophilic factors was negative. Increased homocysteine levels, reduced levels of natural coagulation inhibitors, along with local ophthalmic factors (i.e. glaucoma) justifying thrombosis, were traced in none of the patients. Conclusions 1) APS and thrombophilia Leiden are the most important causal factors for ophthalmic vein thrombosis. However, thrombophilia Leiden alone, does not seem responsible for causing thrombosis, since other thrombophilic factors co-existed in 8/9 patients 2) Hyperhomocysteinemia –in contrast with the results of other studies- does not appear to be a risk factor 3) The high percentage of double heterozygotes (20%) is noteworthy in the aforementioned patients. Disclosures No relevant conflicts of interest to declare.

Anticoagulant therapy after retinal vein occlusion in patients with protein S deficiency

2007 ◽  
Vol 42 (6) ◽  
pp. 875 ◽  
Author(s):  
Matus Rehak ◽  
Vera Krcova ◽  
Ludek Slavik ◽  
Marc Müller ◽  
Jiri Rehak
Keyword(s):  
Retinal Vein Occlusion ◽  
Anticoagulant Therapy ◽  
Protein S ◽  
Protein S Deficiency ◽  
Vein Occlusion ◽  
S Deficiency

Hypercoagulability and High Lipoprotein(a) Levels in Patients with Central Retinal Vein Occlusion

1994 ◽  
Vol 72 (01) ◽  
pp. 039-043 ◽  
Author(s):  
Francesco Bandello ◽  
Silvana Vigano’ D’Angelo ◽  
Mariella Parlavecchia ◽  
Alessandra Tavola ◽  
Patrizia Della Valle ◽  
...  
Keyword(s):  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Specific Treatment ◽  
Fibrin Deposition ◽  
Heparin Cofactor Ii ◽  
Lipoprotein A ◽  
Vein Occlusion ◽  
Acute Event ◽  
D Dimer ◽  
Central Retinal Vein

SummaryA series of coagulation parameters and lipoprotein(a) (Lp(a)) were explored in plasma from 40 patients with central retinal vein occlusion (CRVO, non-ischemic type n = 12; ischemic type n = 28) free of local and systemic predisposing factors, 1 to 12 months after the acute event. Forty age- and sex-matched patients with cataract served as controls. Prothrombin fragment 1.2 (FI.2), D-dimer, FVII:C - but not FVII: Ag - were higher and fibrinogen was lower in CRVO patients than in controls. Patients with non-ischemic CRVO had higher FI .2 and FVII:C and lower heparin cofactor II than patients with ischemic CRVO. Lp(a) levels greater than 300 mg/1 were observed in 12 patients with CRVO and in 4 controls (30% vs 10%, p <0.025). Patients with high Lp(a) - consistently associated with the S2 phenotype - had higher FVII:C, FVII:C/Ag ratio, and fibrinogen than the remaining CRVO patients. Plasma FI.2 and D-dimer correlated fairly in controls (r = 0.41) and patients with normal Lp(a) levels (r = 0.55), but they did not in the group of patients with high Lp(a) (r = 0.19), where the latter parameter was negatively related to D-dimer (r = −0.55). There was no dependence of the abnormalities observed on the time elapsed from vein occlusion. The findings of activated FVII and high FI.2, D-dimer, and Lp(a) are not uncommon in patients with CRVO. Increased thrombin formation with fibrin deposition and impaired fibrinolysis may play a role in the pathophysiology of CRVO and require specific treatment

Retinal Vascular Occlusive Disorders - Risk Factors

2018 ◽  
Vol 3 (02) ◽  
Author(s):  
Shivcharan Lal Chandravanshi, Sunil Kumar Shrivastava, Priyanka Agnihotri, Smriti Gupta
Keyword(s):  
Risk Factors ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Vein Occlusion ◽  
Department Of Ophthalmology ◽  
Retinal Artery ◽  
Central Retinal Vein

Aims and Objective - The aim of the present study is to identify risk factors associated with different retinal vascular occlusive diseases (RVOD), such as central retinal artery occlusion (CRAO), hemi-retinal artery occlusion (HRAO), branch retinal artery occlusion (BRAO), cilioretinal artery occlusion (Cilio-RAO), central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), and hemi-retinal vein occlusion (HRVO). Patients and Method - A cross-sectional study on 114 consecutive subjects, aged 24-96 years who have attended at the outpatient department of ophthalmology at Shyam Shah Medical College, Rewa, MP, were included in the study. The Duration of study was January 2016 to December 2017. Only patients with CRAO, BRAO, HRAO, Cilio-RAO, CRVO, BRVO, and HRVO were included in the study. Other retinal vascular disorders such as diabetic vaso-occlusive disease, anterior and posterior ischemic and non-ischemic neuropathy, hypertensive retinopathy, sickle cell retinopathy, retinal telangiectasia, retinopathy of prematurity, were excluded from study. Results - We have included 114 patients, 64 cases (56.14%) males, 50 (43.85%) females, aged 56+/-8 years (range 24-96 years).  Bilateral retinal vascular occlusive disorders were seen in only 4 cases (3.5%). Two patients have bilateral CRVO followed by one case of bilateral BRVO and one case of bilateral CRAO.  Out of 114 patients, branch retinal vein occlusion was seen in 62 cases (54.38%), followed by central retinal vein occlusion in 36 cases (31.57%), CRAO in 8 cases (7.01%), and hemi- retinal vein occlusion in 4 cases (3.50%). Hypertension was the most common, (40 cases, 35.08%) risk factor identified for retinal vascular occlusive disorders followed by diabetes 24 cases (21.05%), combined diabetes and hypertension in 22 cases (19.29%), and atherosclerosis in 18 cases (15.78%). Conclusions - Retinal vascular occlusive diseases have systemic as well as ocular risk factors. Understanding of these risk factors is essential for proper treatment of RVOD. Timely identification of risk factors for RVOD may helpful in decreasing ocular and systemic morbidity in these patients.

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