young patient
Recently Published Documents





Chemotherapy ◽  
2022 ◽  
pp. 1-5
Natalia Cenfra ◽  
Gianfranco Lapietra ◽  
Salvatore Perrone ◽  
Maria Teresa Voso ◽  
Mariadomenica Divona ◽  

Acute myeloid leukemia (AML) is the most common leukemia in adults. In spite of the most recent discoveries about the molecular landscape of this disease, the treatment of elderly and unfit young patients continues to be a great challenge. The hypomethylating agents (HMA) still represent an effective therapeutic option for these categories, especially for the low-risk subgroups. We report the case of a young patient with NPM1<sup>mut</sup>-AML who underwent a first cycle of intensive induction treatment, achieving a complete remission, but suffered from a serious life-threatening neurologic toxicity. Due to the ineligibility to further lines of intensive chemotherapy, we decided to consolidate the response with azacitidine, administered according to the regular schedule. The minimal residual disease (MRD), monitored through the NPM1 mutation at diagnosis, progressively decreased and became undetectable after 36 cycles of hypomethylating therapy. After 1 year from discontinuation of azacitidine, MRD remains undetectable. Therefore, HMA might still represent a feasible and effective option for patients with low-risk AML, especially when the standard chemotherapy is not indicated, or as maintenance therapy in nontransplantable patients.

Cureus ◽  
2022 ◽  
Hussain A Alobaidi ◽  
Ali A Alfaran ◽  
Hawa H Algazwi ◽  
Fatimah I Alkhater ◽  
Hussain M Alshooalah ◽  

Amine Chaabouni ◽  
Haroun Guermazi ◽  
Mohamed Ali Mseddi ◽  
kais fourati

We report the case of a 42 years old young patient who was examined in the emergency department for epigastric pain lasting for 3 days. The abdominal tomodensitometry allowed to highlight the presence of an intra peritoneal effusion without pneumopertoneum. The patient underwent an exploratory laparoscopy. There was peritoneal toilet

2022 ◽  
Vol 10 (1) ◽  
pp. 283-288
Zi-Yu Li ◽  
Wen-Dan Cheng ◽  
Lei Qi ◽  
Shui-Sheng Yu ◽  
Jue-Hua Jing

Caroline Mieko Tanaka ◽  
Marcelo Fernando Matielo ◽  
Edson Takamitsu Nakamura ◽  
Sergio Roberto Tiossi

CASE ◽  
2022 ◽  
Gauranga Mahalwar ◽  
Nishad Barve ◽  
Muhammad M. Furqan ◽  
Reza M. Reyaldeen ◽  
Ashwin Kumar ◽  

Sign in / Sign up

Export Citation Format

Share Document