Tumor-to-tumor Metastases to Follicular Variant of Papillary Thyroid Carcinoma: Histologic, Immunohistochemical, and Molecular Studies of Two Unusual Cases

2009 ◽  
Vol 20 (4) ◽  
pp. 235-242 ◽  
Author(s):  
Jing Yu ◽  
Marina N. Nikiforova ◽  
Steven P. Hodak ◽  
John H. Yim ◽  
Guoping Cai ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Molecular Studies ◽  
Tumor Metastases

Tumor-to-Tumor Metastasis to Follicular Variant of Papillary Carcinoma of Thyroid

1999 ◽  
Vol 123 (8) ◽  
pp. 703-706 ◽  
Author(s):  
Zubair W. Baloch ◽  
Virginia A. LiVolsi
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Gland ◽  
Thyroid Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Metastasis ◽  
Small Cell ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Tumor To Tumor Metastasis ◽  
Tumor Metastases

Abstract Objective.—To describe and document tumor-to-tumor metastases in the thyroid gland. Methods and Results.—In this series we describe 3 cases of tumor-to-tumor metastasis in which the recipient tumor was a follicular variant of papillary thyroid carcinoma. The donor tumors and sites were small cell carcinoma of the lung, neuroendocrine carcinoma probably of pancreatic origin with initial presentation as liver metastasis, and clear cell carcinoma of the kidney with metastasis to liver and pancreas. The donor tumor cells infiltrated the substance of the follicular variant of papillary thyroid carcinoma, the nontumorous thyroid parenchyma, and the lymphovascular spaces. Small cell carcinoma and neuroendocrine carcinoma showed positive reactivity for neuroendocrine markers and were negative for thyroglobulin and calcitonin. The follicular variant of papillary thyroid carcinoma showed positivity with thyroglobulin and cytokeratin 19. Conclusions.—Although tumor-to-tumor metastases in thyroid gland are exceedingly rare, one should be aware of this phenomenon as the metastatic lesion may simulate a thyroid primary. History of a previous tumor and immunohistochemical stains can be helpful in distinguishing between primary and metastatic thyroid neoplasms.

Follicular thyroid carcinoma and follicular variant papillary thyroid carcinoma: Clinical and histological features depending on the initial size

2017 ◽  
Author(s):  
Fernando Garcia Perez ◽  
Guillermo Martinez de Pinillos Gordillo ◽  
Mariana Tome Fernandez-Ladreda ◽  
Eyvee Arturo Cuellar Lloclla ◽  
Jose Alvaro Romero Porcel ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Initial Size ◽  
Histological Features

A Greek Family with a Follicular Variant of Familial Papillary Thyroid Carcinoma: TCO, MNG1, fPTC/PRN, and NMTC1 Excluded as Susceptibility Loci

Thyroid ◽  
2005 ◽  
Vol 15 (12) ◽  
pp. 1349-1354 ◽  
Author(s):  
Tasoula Tsilchorozidou ◽  
Eleni Vafiadou ◽  
John G. Yovos ◽  
Giovani Romeo ◽  
James McKay ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Susceptibility Loci ◽  
Follicular Variant

scholarly journals Cutaneous metastases on the head and neck from a papillary thyroid carcinoma, follicular variant

2016 ◽  
Vol 107 (1) ◽  
pp. 83-85
Author(s):  
A. Márquez García ◽  
L. Ferrándiz Pulido ◽  
J.J. Ríos-Martín ◽  
F.M. Camacho Martínez
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Head And Neck ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Cutaneous Metastases

scholarly journals The rs2910164 Genetic Variant of miR-146a-3p Is Associated with Increased Overall Mortality in Patients with Follicular Variant Papillary Thyroid Carcinoma

2018 ◽  
Vol 19 (3) ◽  
pp. 655 ◽  
Author(s):  
Marta Kotlarek ◽  
Anna Kubiak ◽  
Małgorzata Czetwertyńska ◽  
Michał Świerniak ◽  
Wojciech Gierlikowski ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Genetic Variant ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Overall Mortality

scholarly journals Effect of Implementing the New Diagnostic Criteria for Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in King Abdulaziz University Hospital

2016 ◽  
Vol 23 (3) ◽  
pp. 31-37
Author(s):  
Fatimah A. Alturkistani ◽  
Murad A. Alturkustani
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Diagnostic Criteria ◽  
University Hospital ◽  
Thyroid Neoplasm ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
King Abdulaziz University ◽  
Nuclear Features

Pathological diagnosis of follicular variant of papillary thyroid carcinoma has high inter and intra-observer variability among expert pathologists, aff ecting prognosis and management of the disease. A recent study applying strict diagnostic criteria and long-term follow up confi rmed the indolent behavior of a subtype of these tumors. They recommended a nomenclature change to noninvasive follicular thyroid neoplasm with papillary-like nuclear features, refl ecting the low risk of adverse outcomes. We searched the pathology archives of King Abdulaziz University Hospital from 2002-2016 for all cases diagnosed with “follicular variant of papillary thyroid carcinoma”. Clinical data, and imaging fi ndings were retrospectively reviewed. Available pathologyslides were reviewed using the proposed inclusion and exclusion diagnostic criteria. We confi rmed the diagnostic reproducibility of the suggested criteria. Ten out of 37 cases met the diagnostic criteria. Eightadditional patients could have had their diagnosis modifi ed if sufficient tissue samples were available. Follow up data confi rmed the indolent behavior in these cases with no recurrence or adverse outcome. We concluded that application of the new diagnostic criteria for this subtype is reasonable and has major ramifi cations for the diagnosis and management as this will spare unnecessary thyroidectomies, radioactive iodine therapy, and their complications.

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