Predicting peptide vaccine candidates against H1N1 influenza virus through theoretical approaches

2015 ◽  
Vol 62 (1) ◽  
pp. 3-15 ◽  
Author(s):  
Martiniano Bello ◽  
Rafael Campos-Rodriguez ◽  
Saul Rojas-Hernandez ◽  
Arturo Contis-Montes de Oca ◽  
José Correa-Basurto
Keyword(s):  
Influenza Virus ◽  
Peptide Vaccine ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
Vaccine Candidates ◽  
Theoretical Approaches

scholarly journals Sequential Seasonal H1N1 Influenza Virus Infections Protect Ferrets against Novel 2009 H1N1 Influenza Virus

2012 ◽  
Vol 87 (3) ◽  
pp. 1400-1410 ◽  
Author(s):  
Donald M. Carter ◽  
Chalise E. Bloom ◽  
Eduardo J. M. Nascimento ◽  
Ernesto T. A. Marques ◽  
Jodi K. Craigo ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H1n1 Influenza ◽  
Cross Reactivity ◽  
Influenza Viruses ◽  
The Novel ◽  
Virus Infections ◽  
H1n1 Influenza Virus ◽  
Virus Shedding ◽  
2009 H1n1 ◽  
Novel H1n1 Influenza

ABSTRACTIndividuals <60 years of age had the lowest incidence of infection, with ∼25% of these people having preexisting, cross-reactive antibodies to novel 2009 H1N1 influenza. Many people >60 years old also had preexisting antibodies to novel H1N1. These observations are puzzling because the seasonal H1N1 viruses circulating during the last 60 years were not antigenically similar to novel H1N1. We therefore hypothesized that a sequence of exposures to antigenically different seasonal H1N1 viruses can elicit an antibody response that protects against novel 2009 H1N1. Ferrets were preinfected with seasonal H1N1 viruses and assessed for cross-reactive antibodies to novel H1N1. Serum from infected ferrets was assayed for cross-reactivity to both seasonal and novel 2009 H1N1 strains. These results were compared to those of ferrets that were sequentially infected with H1N1 viruses isolated prior to 1957 or more-recently isolated viruses. Following seroconversion, ferrets were challenged with novel H1N1 influenza virus and assessed for viral titers in the nasal wash, morbidity, and mortality. There was no hemagglutination inhibition (HAI) cross-reactivity in ferrets infected with any single seasonal H1N1 influenza viruses, with limited protection to challenge. However, sequential H1N1 influenza infections reduced the incidence of disease and elicited cross-reactive antibodies to novel H1N1 isolates. The amount and duration of virus shedding and the frequency of transmission following novel H1N1 challenge were reduced. Exposure to multiple seasonal H1N1 influenza viruses, and not to any single H1N1 influenza virus, elicits a breadth of antibodies that neutralize novel H1N1 even though the host was never exposed to the novel H1N1 influenza viruses.

scholarly journals Individual Antibody and T Cell Responses to Vaccination and Infection with the 2009 Pandemic Swine-Origin H1N1 Influenza Virus

2011 ◽  
Vol 31 (5) ◽  
pp. 900-912 ◽  
Author(s):  
Gillian M. Air ◽  
JingQi Feng ◽  
Tao Chen ◽  
Michelle L. Joachims ◽  
Judith A. James ◽  
...  
Keyword(s):  
Influenza Virus ◽  
T Cell ◽  
T Cell Responses ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
Cell Responses

Anti-Inflammatory Effect of Thalidomide on H1N1 Influenza Virus-Induced Pulmonary Injury in Mice

Inflammation ◽  
2014 ◽  
Vol 37 (6) ◽  
pp. 2091-2098 ◽  
Author(s):  
Haiyan Zhu ◽  
Xunlong Shi ◽  
Dianwen Ju ◽  
Hai Huang ◽  
Wei Wei ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H1n1 Influenza ◽  
Pulmonary Injury ◽  
H1n1 Influenza Virus ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Bleomycin-Fe(II) Agent with Potentiality for Treating Drug-Resistant H1N1 Influenza Virus: A Study Using Electrochemical RNA Beacons

2021 ◽  
pp. 338862
Author(s):  
Jizhen Shang ◽  
Yuchun Qiao ◽  
Guojiang Mao ◽  
Lisheng Qian ◽  
Guodong Liu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H1n1 Influenza ◽  
Drug Resistant ◽  
H1n1 Influenza Virus ◽  
Influenza Virus A

scholarly journals Inhibition of H1N1 influenza virus by selenium nanoparticles loaded with zanamivir through p38 and JNK signaling pathways

RSC Advances ◽  
2017 ◽  
Vol 7 (56) ◽  
pp. 35290-35296 ◽  
Author(s):  
Zhengfang Lin ◽  
Yinghua Li ◽  
Min Guo ◽  
Misi Xiao ◽  
Changbing Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Signaling Pathways ◽  
Clinical Application ◽  
Influenza Virus Infection ◽  
Aqueous Solubility ◽  
H1n1 Influenza ◽  
Solubility Limit ◽  
H1n1 Influenza Virus ◽  
Jnk Signaling

Zanamivir is an effective drug for influenza virus infection, but strong molecular polarity and aqueous solubility limit its clinical application.

Electrocardiographic Abnormalities in Patients With Novel H1N1 Influenza Virus Infection

2010 ◽  
Vol 106 (10) ◽  
pp. 1517-1519 ◽  
Author(s):  
Nikolaos Akritidis ◽  
Maria Mastora ◽  
Gerasimos Baxevanos ◽  
Georgios Dimos ◽  
Georgios Pappas
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
Novel H1n1 Influenza ◽  
Electrocardiographic Abnormalities
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