Correlation of clinical signs and symptoms of Behçet’s disease with platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR)

2021 ◽  
Author(s):  
Soraya Shadmanfar ◽  
Maryam Masoumi ◽  
Fereydoun Davatchi ◽  
Farhad Shahram ◽  
Maassoumeh Akhlaghi ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Behcet's Disease ◽  
Lymphocyte Ratio ◽  
Clinical Signs And Symptoms

Correlation of Clinical Signs and Symptoms of Behçet’s Disease With Platelet to Lymphocyte Ratio (PLR) and Neutrophil to Lymphocyte Ratio (NLR)

2021 ◽  
Author(s):  
Soraya Shadmanfar ◽  
Maryam Masoumi ◽  
Fereydoun Davatchi ◽  
Farhad Shahram ◽  
Maassoumeh Akhlaghi ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neutrophil To Lymphocyte Ratio ◽  
P Value ◽  
Platelet To Lymphocyte Ratio ◽  
Behcet's Disease ◽  
Lymphocyte Ratio ◽  
Spearman's Rho ◽  
Spearman’S Rho

Abstract BackgroundBehçet’s disease (BD) is a chronic disorder that involves multiple organs and is pathologically considered as a form of vasculitis. The current study aims to assess the metric properties of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) in assessing BD disease activity.MethodsThree-hundred-nineteen patients with BD were enrolled in this cross-sectional study. Demographic and epidemiological data, including IBDDAM, time since the onset, and medication and manifestation history was recorded. Complete blood counts (CBC), NLR, and PLR were assessed by analyzing blood samples. On the last visit, patients were assessed for active manifestations of disease. IBDDAM and ocular IBDAAM scores were calculated for activity of disease in each patient.ResultsBoth PLR and NLR were higher in patients with active BD (Man-Whitney U test, P-value<0.05). Patients with active ocular manifestation had significantly higher NLR and PLR (Man-Whitney U test, P-value<0.05). These ratios, however, were not associated with other active BD manifestations. A value of NLR >2.58 had 46% sensitivity and 85% specificity for the diagnosis of active ocular manifestations (AUC: 0.690). NLR had a significant though weak positive correlation with IBDDAM (Spearman’s rho = 0.162; p-value <0.05) and ocular IBDDAM (Spearman’s rho = 0.159; p-value < 0.05). ConclusionActive Behçet’s presented with higher NLR and PLR ratios; however, there was only a modest correlation between NLR and BD activity (IBDDAM score). Also NLR and PLR have significant relationship with ocular features of BD patients.

FRI0208 CORRELATIONS BETWEEN NEUTROPHIL-TO-LYMPHOCYTE RATIO AND TH17/TREG IMMUNE BALANCE IN PATIENTS WITH BEHCET’S DISEASE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 687-688
Author(s):  
Y. Liu ◽  
R. Su ◽  
X. Zheng ◽  
X. LI ◽  
C. Wang
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neutrophil To Lymphocyte Ratio ◽  
Healthy Controls ◽  
Behcet's Disease ◽  
Lymphocyte Ratio ◽  
Immune Balance ◽  
The Absolute ◽  
Immune Imbalance

Background:Behcet’s disease(BD) is a systemic perivasculitis where mucocutaneous manifestations are well known to show neutrophilic dermatosis denoted by significant neutrophil infiltration[1]. The neutrophil-to-lymphocyte ratio has been proved as an inflammatory biomarkers in BD[2].At present, the Th17/Treg immune imbalance may be the involved factors in the pathway of BD[3].However, the correlations between the number of neutrophil, the number of lymphocyte, the neutrophil-to-lymphocyte ratio(NLR) and Th17/Treg immune imbalance remain unclear.Objectives:The aim of this study was to examine correlations between the number of neutrophil, the number of lymphocyte, the neutrophil-to-lymphocyte ratio and Th17/Treg immune balance in patients with BD.Methods:The study included 59 BD patients and 66 healthy controls. The absolute counts of lymphocyte subsets and CD4+T cell subsets were detected by flow cytometry for all participants. The neutrophil and lymphocyte were measured by routine blood test for all BD patients. To calculate the NLR, the ratio of absolute neutrophil count to absolute lymphocyte count was obtained. The Mann–Whitney U test was used to compare continuous measures. Correlations between the number of neutrophil, the number of lymphocyte, the NLR and Th17/Treg immune balance were assessed by Spearman’s rank correlation tests.Results:(1)Compared to healthy controls, the absolute counts of NK cells were decreased (P=0.047), the absolute counts of B cells were increased(P=0.021), the absolute counts of CD4+T cells were also increased(P=0.035), the absolute counts of Th1 and Th17 cells were significantly increased(P< 0.005), the absolute counts of Th2 and Treg cells were decreased (P< 0.05), the ratio of Th1/Th2 and Th17/Treg were increased(P< 0.001) in BD group. (2)The numbers of neutrophil were positively correlated with Th17/Treg(r=0.344,P=0.008); The NLR was positively correlated with Th17/Treg(r=0.291,P=0.026).Conclusion:Our research shows that T cell homeostasis perturbation, especially Th17 expansion, Treg insufficiency and Th17/Treg immune imbalance, is the cornerstone of BD pathogenesis. Except neutrophil, these findings suggest that imbalance Th17/Treg may be dominant in the pathogenesis of BD. The NLR was positively correlated with Th17/Treg.Further studies are required to evaluate these preliminary findings in different patient populations and also examine the possible molecular mechanisms behind our observations.References:[1]Tong B, Liu X, Xiao J et al. Immunopathogenesis of Behcet’s Disease[J]. Front Immunol,2019,10:665.DOI:10.3389/fimmu.2019.00665.[2]Gheita TA, Sakr BR, Rabea RE et al. Value of hematological indices versus VEGF as biomarkers of activity in Behçet’s disease[J]. Clin Rheumatol. 2019,38(8):2201–2210. DOI:10.1007/s10067-019-04513-5.[3]Ahmadi M, Yousefi M, Abbaspour-Aghdam S et al. Disturbed Th17/Treg balance, cytokines, and miRNAs in peripheral blood of patients with Behcet’s disease[J]. J Cell Physiol, 2018,234(4):3985-3994.DOI:10.1002/jcp.27207.Figure 1.The absolute counts of lymphocyte subsets in BD patients and healthy controls. Data are expressed as means ±SD.Figure 2.Correlation coefficient and regression line of the number of Th17 cells, the number of Treg cells, Th17/Treg with the the number of neutrophil, the number of lymphocyte, the NLR were represented as scatter plots.Disclosure of Interests:None declared

scholarly journals Behcet’s Disease: An In-depth Review About Pathogenesis, Gastrointestinal Manifestations And Management

2021 ◽  
Author(s):  
Anthony Nguyen ◽  
Shubhra Upadhyay ◽  
Muhammad Ali Javaid ◽  
Abdul Moiz Qureshi ◽  
Shahan Haseeb ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Vascular Disorder ◽  
Robust Algorithms ◽  
Behcet's Disease ◽  
Relapsing Remitting

Background: Behcet’s Disease (BD) is a complex inflammatory vascular disorder that follows a relapsing-remitting course with diverse clinical manifestations. The prevalence of the disease varies throughout the globe and targets different age groups. There are many variations of BD, however, intestinal BD is not only more common but has many signs and symptoms. Summary: BD is a relapsing-remitting inflammatory vascular disorder with multiple system involvement, affecting vessels of all types and sizes that targets young adults. The etiology of BD is unknown but many factors including genetic mechanisms, vascular changes, hypercoagulability and dysregulation of immune function are believed to be responsible. BD usually presents with signs and symptoms of ulcerative disease of the small intestine; endoscopy being consistent with the clinical manifestations. The mainstay of treatment depends upon the severity of the disease. Corticosteroids are recommended for severe forms of the disease and aminosalicylic acids are used in maintaining remission in mild to moderate forms of the disease. Key messages: In this review, we have tried to summarize in the present review the clinical manifestations, differential diagnoses and management of intestinal BD. Hopefully, this review will enable health policymakers to ponder over establishing clear endpoints for treatment, surveillance investigations and creating robust algorithms.

Investigation of the arterial intima-media thickness in Behcet’s disease patients without vascular complaints

Vascular ◽  
2017 ◽  
Vol 26 (4) ◽  
pp. 356-361
Author(s):  
Nazım Kankilic ◽  
Aydın Aslan ◽  
Oguz Karahan ◽  
Sinan Demirtas ◽  
Ahmet Caliskan ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Intima Media Thickness ◽  
Vascular Involvement ◽  
Behcet's Disease ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Media Thickness ◽  
Arterial Intima

Objectives Behcet’s disease is a multisystemic, inflammatory disease. Various factors have been implicated in the disease, including genetics, infections, immunoglobulins, immune complexes, antibodies, and oxidative stress. However, the underlying etiopathogenesis remains unclear. Behcet’s disease can occur with or without vascular involvement. This prospective study investigated the relationship between the intima-media thickness of the major arteries, in addition to other factors affecting the disease process, in Behcet’s disease without vascular involvement. Methods Twenty-four patients (average age: 38.50 ± 10.931) without vascular involvement or any vascular complaints who were diagnosed with Behcet’s disease were included in the study. Sixteen healthy subjects (average age: 39.75 ± 7.793) were included as a control group. Demographic information and medical histories were recorded, and routine blood tests were performed in both groups. The intima-media thickness of the subclavian, axillary, femoral, and carotid arteries of all the participants were recorded using Doppler ultrasonography. The data were then subjected to intergroup statistical and correlation analyses. Results There were no significant differences between the arterial intima-media thickness values of the Behcet’s disease patients and those of the control group ( p > 0.05). However, there was a significant difference between the neutrophil–lymphocyte ratio ( p = 0.004), low-density lipoprotein ( p = 0.007), and triglyceride ( p = 0042) levels of the two groups. Significant correlations were found between intima-media thickness and neutrophil–lymphocyte ratio levels ( p = 0.012) and the disease duration ( p = 0.030). There was also a significant correlation between the intima-media thickness of the femoral artery and disease duration ( p = 0.014). Conclusions The results showed that the duration of illness had a significant effect on arterial intima-media thickness in Behcet’s disease. Blood neutrophil–lymphocyte ratio levels were also associated with increased intima-media thickness.

scholarly journals Correction to: Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in Behçet’s disease: which and when to use?

2019 ◽  
Vol 38 (7) ◽  
pp. 2019-2019
Author(s):  
Marwa Hammad ◽  
Omaima Zakaria Shehata ◽  
Shaimaa Mohamed Abdel-Latif ◽  
Amany Mohamed Mohiey El-Din
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio
Sign in / Sign up

Export Citation Format

Share Document