Neutrophil to lymphocyte ratio in Behçet’s disease as a marker of disease activity Running title: NLR in Behçet’s disease

2014 ◽  
Vol 23 (4) ◽  
Author(s):  
Emine Nur Rifaioglu ◽  
Bilge Bülbül Şen ◽  
Özlem Ekiz ◽  
Asena Cigdem Dogramaci
Keyword(s):  
Disease Activity ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neutrophil To Lymphocyte Ratio ◽  
Behcet's Disease ◽  
Lymphocyte Ratio

Correlation of Clinical Signs and Symptoms of Behçet’s Disease With Platelet to Lymphocyte Ratio (PLR) and Neutrophil to Lymphocyte Ratio (NLR)

2021 ◽  
Author(s):  
Soraya Shadmanfar ◽  
Maryam Masoumi ◽  
Fereydoun Davatchi ◽  
Farhad Shahram ◽  
Maassoumeh Akhlaghi ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neutrophil To Lymphocyte Ratio ◽  
P Value ◽  
Platelet To Lymphocyte Ratio ◽  
Behcet's Disease ◽  
Lymphocyte Ratio ◽  
Spearman's Rho ◽  
Spearman’S Rho

Abstract BackgroundBehçet’s disease (BD) is a chronic disorder that involves multiple organs and is pathologically considered as a form of vasculitis. The current study aims to assess the metric properties of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) in assessing BD disease activity.MethodsThree-hundred-nineteen patients with BD were enrolled in this cross-sectional study. Demographic and epidemiological data, including IBDDAM, time since the onset, and medication and manifestation history was recorded. Complete blood counts (CBC), NLR, and PLR were assessed by analyzing blood samples. On the last visit, patients were assessed for active manifestations of disease. IBDDAM and ocular IBDAAM scores were calculated for activity of disease in each patient.ResultsBoth PLR and NLR were higher in patients with active BD (Man-Whitney U test, P-value<0.05). Patients with active ocular manifestation had significantly higher NLR and PLR (Man-Whitney U test, P-value<0.05). These ratios, however, were not associated with other active BD manifestations. A value of NLR >2.58 had 46% sensitivity and 85% specificity for the diagnosis of active ocular manifestations (AUC: 0.690). NLR had a significant though weak positive correlation with IBDDAM (Spearman’s rho = 0.162; p-value <0.05) and ocular IBDDAM (Spearman’s rho = 0.159; p-value < 0.05). ConclusionActive Behçet’s presented with higher NLR and PLR ratios; however, there was only a modest correlation between NLR and BD activity (IBDDAM score). Also NLR and PLR have significant relationship with ocular features of BD patients.

FRI0208 CORRELATIONS BETWEEN NEUTROPHIL-TO-LYMPHOCYTE RATIO AND TH17/TREG IMMUNE BALANCE IN PATIENTS WITH BEHCET’S DISEASE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 687-688
Author(s):  
Y. Liu ◽  
R. Su ◽  
X. Zheng ◽  
X. LI ◽  
C. Wang
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neutrophil To Lymphocyte Ratio ◽  
Healthy Controls ◽  
Behcet's Disease ◽  
Lymphocyte Ratio ◽  
Immune Balance ◽  
The Absolute ◽  
Immune Imbalance

Background:Behcet’s disease(BD) is a systemic perivasculitis where mucocutaneous manifestations are well known to show neutrophilic dermatosis denoted by significant neutrophil infiltration[1]. The neutrophil-to-lymphocyte ratio has been proved as an inflammatory biomarkers in BD[2].At present, the Th17/Treg immune imbalance may be the involved factors in the pathway of BD[3].However, the correlations between the number of neutrophil, the number of lymphocyte, the neutrophil-to-lymphocyte ratio(NLR) and Th17/Treg immune imbalance remain unclear.Objectives:The aim of this study was to examine correlations between the number of neutrophil, the number of lymphocyte, the neutrophil-to-lymphocyte ratio and Th17/Treg immune balance in patients with BD.Methods:The study included 59 BD patients and 66 healthy controls. The absolute counts of lymphocyte subsets and CD4+T cell subsets were detected by flow cytometry for all participants. The neutrophil and lymphocyte were measured by routine blood test for all BD patients. To calculate the NLR, the ratio of absolute neutrophil count to absolute lymphocyte count was obtained. The Mann–Whitney U test was used to compare continuous measures. Correlations between the number of neutrophil, the number of lymphocyte, the NLR and Th17/Treg immune balance were assessed by Spearman’s rank correlation tests.Results:(1)Compared to healthy controls, the absolute counts of NK cells were decreased (P=0.047), the absolute counts of B cells were increased(P=0.021), the absolute counts of CD4+T cells were also increased(P=0.035), the absolute counts of Th1 and Th17 cells were significantly increased(P< 0.005), the absolute counts of Th2 and Treg cells were decreased (P< 0.05), the ratio of Th1/Th2 and Th17/Treg were increased(P< 0.001) in BD group. (2)The numbers of neutrophil were positively correlated with Th17/Treg(r=0.344,P=0.008); The NLR was positively correlated with Th17/Treg(r=0.291,P=0.026).Conclusion:Our research shows that T cell homeostasis perturbation, especially Th17 expansion, Treg insufficiency and Th17/Treg immune imbalance, is the cornerstone of BD pathogenesis. Except neutrophil, these findings suggest that imbalance Th17/Treg may be dominant in the pathogenesis of BD. The NLR was positively correlated with Th17/Treg.Further studies are required to evaluate these preliminary findings in different patient populations and also examine the possible molecular mechanisms behind our observations.References:[1]Tong B, Liu X, Xiao J et al. Immunopathogenesis of Behcet’s Disease[J]. Front Immunol,2019,10:665.DOI:10.3389/fimmu.2019.00665.[2]Gheita TA, Sakr BR, Rabea RE et al. Value of hematological indices versus VEGF as biomarkers of activity in Behçet’s disease[J]. Clin Rheumatol. 2019,38(8):2201–2210. DOI:10.1007/s10067-019-04513-5.[3]Ahmadi M, Yousefi M, Abbaspour-Aghdam S et al. Disturbed Th17/Treg balance, cytokines, and miRNAs in peripheral blood of patients with Behcet’s disease[J]. J Cell Physiol, 2018,234(4):3985-3994.DOI:10.1002/jcp.27207.Figure 1.The absolute counts of lymphocyte subsets in BD patients and healthy controls. Data are expressed as means ±SD.Figure 2.Correlation coefficient and regression line of the number of Th17 cells, the number of Treg cells, Th17/Treg with the the number of neutrophil, the number of lymphocyte, the NLR were represented as scatter plots.Disclosure of Interests:None declared

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