Role of cAMP-Dependent Protein Kinase A Activity in Low-Dose Endothelial Monocyte-Activating Polypeptide-II-Induced Opening of Blood–Tumor Barrier

2014 ◽  
Vol 56 (1) ◽  
pp. 60-69 ◽  
Author(s):  
Zhen Li ◽  
Xiao-bai Liu ◽  
Yun-hui Liu ◽  
Yi-xue Xue ◽  
Ping Wang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Low Dose ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Kinase A

NO releases bombesin-like immunoreactivity from enteric synaptosomes by cross-activation of protein kinase A

1999 ◽  
Vol 276 (6) ◽  
pp. G1521-G1530 ◽  
Author(s):  
M. Kurjak ◽  
R. Fritsch ◽  
D. Saur ◽  
V. Schusdziarra ◽  
H. D. Allescher
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Dependent Protein Kinase ◽  
No Donor ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Camp Levels ◽  
No Releases ◽  
Kinase A

The effect of nitric oxide (NO) on the release of bombesin-like immunoreactivity (BLI) was examined in synaptosomes of rat small intestine. The NO donor S-nitroso- N-acetylpenicillamine (SNAP; 10−7 to 10−4 M) significantly stimulated BLI release. In the presence of the NO scavenger oxyhemoglobin (10−3 M) or the guanylate cyclase inhibitor ODQ (10−5 M), SNAP-induced BLI release was antagonized. In addition, SNAP increased the synaptosomal cGMP content and elevation of cGMP levels by zaprinast (3 × 10−5 M), an inhibitor of the cGMP-specific phosphodiesterase (PDE) type 5, and increased basal and SNAP-induced BLI release. NO-induced BLI release was blocked by Rp-adenosine 3′,5′-cyclic monophosphorothioate (3 × 10−5 M and 10−4 M), an inhibitor of the cAMP-dependent protein kinase A, whereas KT-5823 (3 × 10−6 M) and Rp-8-(4-chlorophenylthio)-cGMP (5 × 10−5M), inhibitors of the cGMP-dependent protein kinase G, had no effect. Because cGMP inhibits the cAMP-specific PDE3, thereby increasing cAMP levels, the role of PDE3 was investigated. Trequinsin (10−8 M), a specific blocker of PDE3, stimulated basal BLI release but had no additive effect on NO-induced release, suggesting a similar mechanism of action. These data demonstrate that because of a cross-activation of cAMP-dependent protein kinase A by endogenous cGMP BLI can be released by NO from enteric synaptosomes.

scholarly journals Role of N-Myristoylation of Camp-Dependent Protein Kinase a in Recognition and Phosphorylation of Membrane-Bound Substrates

2011 ◽  
Vol 100 (3) ◽  
pp. 639a
Author(s):  
Ece C. Gaffarogullari ◽  
Emily E. Metcalfe ◽  
Larry R. Masterson ◽  
Nate Traaseth ◽  
Dan Mullen ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Membrane Bound ◽  
Kinase A

scholarly journals Increased expression of the RIα subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer

1999 ◽  
Vol 79 (5-6) ◽  
pp. 933-939 ◽  
Author(s):  
H M McDaid ◽  
M T Cairns ◽  
R J Atkinson ◽  
S McAleer ◽  
D P Harkin ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Advanced Stage ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Kinase A

cAMP-Dependent Protein Kinase A-Stimulated Sarcoplasmic Reticulum Function in Heart Failurea

1998 ◽  
Vol 853 (1 CARDIAC SARCO) ◽  
pp. 240-250 ◽  
Author(s):  
ROBERT H. G. SCHWINGER ◽  
BIRGIT BOLCK ◽  
GOTZ MUNCH ◽  
KLARA BRIXIUS ◽  
JOCHEN MULLER-EHMSEN ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Sarcoplasmic Reticulum ◽  
Protein Kinase A ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Kinase A
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