Citalopram Attenuates Tau Hyperphosphorylation and Spatial Memory Deficit Induced by Social Isolation Rearing in Middle-Aged Rats

2014 ◽  
Vol 56 (1) ◽  
pp. 145-153 ◽  
Author(s):  
Qing-Guo Ren ◽  
Wei-Gang Gong ◽  
Yan-Juan Wang ◽  
Qi-Da Zhou ◽  
Zhi-Jun Zhang
Keyword(s):  
Spatial Memory ◽  
Social Isolation ◽  
Memory Deficit ◽  
Tau Hyperphosphorylation ◽  
Aged Rats ◽  
Isolation Rearing ◽  
Middle Aged ◽  
Spatial Memory Deficit ◽  
Social Isolation Rearing

Spatial memory deficit and Tau hyperphosphorylation induced by inhibiting PP2A in rat brain

2005 ◽  
Vol 10 (6) ◽  
pp. 1030-1034
Author(s):  
Tian Qing ◽  
Zheng Hong-yun ◽  
Chen Juan ◽  
Li Hong-lian ◽  
Gong Cheng-xin ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Rat Brain ◽  
Memory Deficit ◽  
Tau Hyperphosphorylation ◽  
Spatial Memory Deficit

Correlation of Behavior Changes and BOLD Signal in Alzheimer-like Rat Model

2004 ◽  
Vol 36 (12) ◽  
pp. 803-810 ◽  
Author(s):  
Zheng-Hui Hu ◽  
Xiao-Chuan Wang ◽  
Li-Yun Li ◽  
Mai-Li Liu ◽  
Rong Liu ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Rat Model ◽  
Linear Regression Analysis ◽  
Memory Deficit ◽  
Blood Oxygenation ◽  
Morris Water Maze Test ◽  
Sensitivity Threshold ◽  
Tau Hyperphosphorylation ◽  
Memory Retention ◽  
Spatial Memory Deficit

Abstract To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2* signal and tau hyperphosphorylation/spatial memory deficit. The rat model with tau hyperphosphorylation and spatial memory deficit was established by bilateral hippocampi injection of isoproterenol (IP). Then, the correlative alteration between resting T2* signal and spatial memory retention was assessed with blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) study and Morris Water Maze test, and Western blot was employed to confirm tau hyperphosphorylation. The analysis showed following results. (1) Tau phosphorylation at Ser396/Ser404 and Ser199/Ser202 was significantly increased in IP-injected rats as detected by PHF-1 and tau-1, respectively. (2) An AD-like spatial memory retention disturbance was induced at 24 h after isoproterenol injection. (3) A sensitivity threshold of resting T2* signal intensity, which separated the IP-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 32.62. These results suggest that resting T2* signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation.

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