scholarly journals Clear cell predominant epithelial-myoepithelial carcinoma of the hard palate — role of immunohistochemistry

2008 ◽  
Vol 60 (2) ◽  
pp. 163-165 ◽  
Author(s):  
Radha R. Pai ◽  
Kausalya Sahu ◽  
Anand U. Kini
Keyword(s):  
Hard Palate ◽  
Clear Cell ◽  
Myoepithelial Carcinoma ◽  
Epithelial Myoepithelial Carcinoma

scholarly journals Clear Cell Myoepithelial Carcinoma Arising from the Hard Palate with Metastasis to the Lungs

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Jiayun Fang ◽  
Amanda Kornfield ◽  
Alex Clavijo ◽  
Shikhar Vyas ◽  
Alison Ulbrandt ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Aggressive Behavior ◽  
Salivary Glands ◽  
Hard Palate ◽  
Clear Cell ◽  
Pulmonary Nodules ◽  
Myoepithelial Carcinoma ◽  
Elderly Male ◽  
Resection Specimen ◽  
Uncommon Tumor

Myoepithelial carcinoma is an uncommon tumor of the salivary glands, most commonly the parotid gland. Clear cell myoepithelial carcinoma is a rare variant with an aggressive behavior. Here, we describe a case of clear cell myoepithelial carcinoma arising from the hard palate in an elderly male who underwent resection of the tumor and postop radiation. Posttreatment imaging demonstrated bilateral pulmonary nodules and a C2 body lesion concerning for metastasis. Biopsy of the lung lesions revealed a monomorphous population of optically clear cells with hyperchromatic and pleomorphic nuclei which were morphologically similar to the prior resection specimen. There are few reported cases of clear cell myoepithelial carcinoma arising from the hard palate, and there are even fewer reports on metastases to the lungs. Due to the low number of reported cases, prognosis and treatment of this neoplasm is not well defined.

scholarly journals Epithelial-myoepithelial carcinoma of floor of mouth: A case report of double clear cell variant with immunohistochemical correlation

2020 ◽  
pp. 181
Author(s):  
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Clear Cell ◽  
Cell Types ◽  
Myoepithelial Carcinoma ◽  
Clear Cells ◽  
Floor Of Mouth ◽  
Cell Variant ◽  
Epithelial Myoepithelial Carcinoma ◽  
Clear Cell Variant

Epithelial-myoepithelial carcinoma (EMC) is a rare biphasic low-grade malignancy accounting for only 0.5% of all salivary gland tumors. Commonly, EMC affects parotid gland (70%) and rarely affecting other salivary glands. Clearing of both, epithelial and myoepithelial cell types, is rare and gives an impression of a monocellular neoplasm. Case report: A 42-year-old male reported to Oral and Maxillofacial Surgery Department in Faculty of Oral and Dental Medicine, Misr International University with a painless growth in the floor of mouth since 5 years. The soft tissue window of computerized tomography (CT) revealed a well-circumscribed swelling in the sublingual space. The provisional diagnosis was pleomorphic adenoma. Results: The histopathological examination showed solid sheets of rounded to polyhedral clear cells forming lobes and lobules separated by connective tissue mucoid septa. A thin fibrous capsule, invaded with some tumor cells was also present. The presented pattern of clear cells together with the encapsulation of the tumor provides an impression of clear cell variant of monocellular neoplasm. Conclusion: The presented case relates to an epithelial-myoepithelial carcinoma originating from the sublingual salivary gland, which is a rare site for this lesion. Based on immunohistochemical staining, differentiation between the double clear cell types was confirmed using S-100 protein and SMA for the myoepithelial nature of the outer cells while the epithelial nature of the inner cells was confirmed by CK-19 and EMA. Thus, the diagnosis of double clear cell variant of EMC was given.

scholarly journals Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Karl Grenier ◽  
Gulbeyaz Altinel ◽  
Zari Dastani ◽  
Atilla Omeroglu
Keyword(s):  
Clear Cell ◽  
Phyllodes Tumor ◽  
Myoepithelial Cells ◽  
Metaplastic Carcinoma ◽  
Myoepithelial Carcinoma ◽  
Diagnostic Challenge ◽  
Carcinoma Of The Breast ◽  
Epithelial Myoepithelial Carcinoma ◽  
Rhabdoid Differentiation ◽  
Rhabdoid Features

Epithelial-myoepithelial carcinoma of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Myoepithelial cells are known to adopt varied morphologies, including spindle, chondroid, clear cell, and rhabdoid morphologies, and can represent a diagnostic challenge when isolated on biopsy. Rhabdomyosarcoma, phyllodes tumor, metaplastic carcinoma, and myoepithelial carcinoma are primary breast tumors that all have been shown to exhibit rhabdoid features, whether representing true differentiation or morphological mimic. We here report an epithelial-myoepithelial carcinoma of the breast with rhabdoid features in a 76-year-old woman. The rhabdoid-appearing myoepithelial cells are negative for myogenin, consistent with a rhabdoid-like morphology rather than a true rhabdoid differentiation, comparably to previously described myoepithelial carcinoma with rhabdoid features. To our knowledge, this is the first reported case of epithelial-myoepithelial carcinoma of the breast with rhabdoid features and thus adds another entity to the differential diagnosis of breast lesions with rhabdoid features.

scholarly journals A case of epithelial-myoepithelial carcinoma arising in the hard palate

2019 ◽  
Vol 65 (5) ◽  
pp. 318-322
Author(s):  
Satoru OGANE ◽  
Eiko SUZUKI ◽  
Takeshi ONDA ◽  
Takeshi NOMURA ◽  
Akira KATAKURA ◽  
...  
Keyword(s):  
Hard Palate ◽  
Myoepithelial Carcinoma ◽  
Epithelial Myoepithelial Carcinoma

Clear Cell Epithelial-myoepithelial Carcinoma Arising in Pleomorphic Adenoma of the Lacrimal Gland

Ophthalmology ◽  
1994 ◽  
Vol 101 (5) ◽  
pp. 925-930 ◽  
Author(s):  
Mary L. Ostrowski ◽  
Ramon L. Font ◽  
Jesse Halpern ◽  
Ernst Nicolitz ◽  
Robert Barnes
Keyword(s):  
Pleomorphic Adenoma ◽  
Lacrimal Gland ◽  
Clear Cell ◽  
Myoepithelial Carcinoma ◽  
Epithelial Myoepithelial Carcinoma

Epithelial-myoepithelial carcinoma arising from clear cell myoepithelioma of the parotid

Pathology ◽  
2002 ◽  
Vol 34 (5) ◽  
pp. 475-477
Author(s):  
Javier Azúa-Romeo ◽  
Tomás Usón ◽  
Amelia Martinez-Tello ◽  
Ramiro Alvarez-Alegret ◽  
Ignacio Moral
Keyword(s):  
Clear Cell ◽  
Myoepithelial Carcinoma ◽  
Epithelial Myoepithelial Carcinoma

scholarly journals Epithelial-Myoepithelial Carcinoma of The Minor Salivary Glands: Report of Two Cases with Literature Review

2021 ◽  
Author(s):  
Kohei Okuyama ◽  
Yasuyuki Michi ◽  
Yoshihisa Kashima ◽  
Hirofumi Tomioka ◽  
Hideaki Hiral ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Literature Review ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Hard Palate ◽  
Tumor Resection ◽  
Myoepithelial Carcinoma ◽  
Incisional Biopsy ◽  
Minor Salivary Glands ◽  
Epithelial Myoepithelial Carcinoma

Abstract Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland tumor, which is especially uncommon in the minor salivary glands (MSG). We report literature review of EMC of the MSGs with our experience of two cases. Case 1 is a 75-year-old woman with a hard elastic mass in the hard palate, sized 2.5 × 2 cm without ulceration. Incisional biopsy was suggestive of pleomorphic adenoma. Tumor resection was performed with adequate surgical margin. Case 2 is a 44-year-old woman with a mass in the hard palate, sized 1.8 × 1.6 cm without ulceration. Incisional biopsy was suggestive of pleomorphic adenoma or a low-grade salivary gland carcinoma and intraoral tumor resection was performed. Both have good postoperative courses and are alive with no evidence of local recurrence or metastasis at 25 and 10 months. The Ki-67 labeling index in Case 1 and 2 were 10.6 and 3.8 %. Considering that the anatomy, structure, and size of salivary glands are quite different from MSGs, EMCs of the MSG cannot be predicted similarly to EMCs of the major salivary glands. The present review with 18 cases revealed no consensus on treatment methods for MSG cases other than surgery.

Sign in / Sign up

Export Citation Format

Share Document