scholarly journals p16 Immunohistochemistry As a Standalone Test for Risk Stratification in Oropharyngeal Squamous Cell Carcinoma

2012 ◽  
Vol 6 (S1) ◽  
pp. 75-82 ◽  
Author(s):  
James S. Lewis
Keyword(s):  
Squamous Cell Carcinoma ◽  
Risk Stratification ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
P16 Immunohistochemistry

scholarly journals Prognostic utility of HPV specific testing in addition to p16 immunohistochemistry in oropharyngeal squamous cell carcinoma

2018 ◽  
Vol 29 (10) ◽  
pp. 2144-2145 ◽  
Author(s):  
H.P. Sathasivam ◽  
A. Santambrogio ◽  
C.L. Andoniadou ◽  
M. Robinson ◽  
S. Thavaraj
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
P16 Immunohistochemistry ◽  
Prognostic Utility

scholarly journals Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1778
Author(s):  
Stefan P. Haider ◽  
Tal Zeevi ◽  
Philipp Baumeister ◽  
Christoph Reichel ◽  
Kariem Sharaf ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Risk Stratification ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Added Value ◽  
Imaging Features ◽  
Cervical Lymph Nodes ◽  
Pet Ct ◽  
8Th Edition

Accurate risk-stratification can facilitate precision therapy in oropharyngeal squamous cell carcinoma (OPSCC). We explored the potential added value of baseline positron emission tomography (PET)/computed tomography (CT) radiomic features for prognostication and risk stratification of OPSCC beyond the American Joint Committee on Cancer (AJCC) 8th edition staging scheme. Using institutional and publicly available datasets, we included OPSCC patients with known human papillomavirus (HPV) status, without baseline distant metastasis and treated with curative intent. We extracted 1037 PET and 1037 CT radiomic features quantifying lesion shape, imaging intensity, and texture patterns from primary tumors and metastatic cervical lymph nodes. Utilizing random forest algorithms, we devised novel machine-learning models for OPSCC progression-free survival (PFS) and overall survival (OS) using “radiomics” features, “AJCC” variables, and the “combined” set as input. We designed both single- (PET or CT) and combined-modality (PET/CT) models. Harrell’s C-index quantified survival model performance; risk stratification was evaluated in Kaplan–Meier analysis. A total of 311 patients were included. In HPV-associated OPSCC, the best “radiomics” model achieved an average C-index ± standard deviation of 0.62 ± 0.05 (p = 0.02) for PFS prediction, compared to 0.54 ± 0.06 (p = 0.32) utilizing “AJCC” variables. Radiomics-based risk-stratification of HPV-associated OPSCC was significant for PFS and OS. Similar trends were observed in HPV-negative OPSCC. In conclusion, radiomics imaging features extracted from pre-treatment PET/CT may provide complimentary information to the current AJCC staging scheme for survival prognostication and risk-stratification of HPV-associated OPSCC.

scholarly journals First case of Ethmoid Metastasis From an Induced Oropharyngeal Squamous Cell Carcinoma HPV, Interest of the P16 as a Diagnosis Aid

2020 ◽  
pp. 014556132095512
Author(s):  
Younès Steffens ◽  
Quentin Mat ◽  
Vincent Beatse ◽  
Nicolas Meert ◽  
Nathalie Nagy ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
First Case ◽  
P16 Immunohistochemistry ◽  
P16 Overexpression

We describe the first case of ethmoid metastasis from an oropharyngeal human papillomavirus–induced squamous cell carcinoma using the anti-P16 immunohistochemistry. The p16 overexpression can be a valuable aid in the differential diagnosis.

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