scholarly journals Ultrastructural Characterization of Mammary Analogue Secretory Carcinoma of the Salivary Glands: A Distinct Entity from Acinic Cell Carcinoma?

2017 ◽  
Vol 11 (4) ◽  
pp. 419-426 ◽  
Author(s):  
Julie Guilmette ◽  
Gunnlaugur P. Nielsen ◽  
William C. Faquin ◽  
Martin Selig ◽  
Vânia Nosé ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Acinic Cell Carcinoma ◽  
Secretory Carcinoma ◽  
Distinct Entity ◽  
Mammary Analogue Secretory Carcinoma ◽  
Acinic Cell ◽  
Ultrastructural Characterization

scholarly journals Lysozyme Expression Can be Useful to Distinguish Mammary Analog Secretory Carcinoma from Acinic Cell Carcinoma of Salivary Glands

2016 ◽  
Vol 10 (4) ◽  
pp. 429-436 ◽  
Author(s):  
Fernanda Viviane Mariano ◽  
Camila Andrea Concha Gómez ◽  
Juliana de Souza do Nascimento ◽  
Harim Tavares dos Santos ◽  
Erika Said Egal ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Acinic Cell Carcinoma ◽  
Secretory Carcinoma ◽  
Acinic Cell ◽  
Mammary Analog Secretory Carcinoma

scholarly journals Mammary Analogue Secretory Carcinoma

2016 ◽  
Vol 140 (9) ◽  
pp. 997-1001 ◽  
Author(s):  
Todd M. Stevens ◽  
Vishwas Parekh
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Salivary Gland Tumor ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Duct Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
Acinic Cell ◽  
Not Otherwise Specified

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that shares the same histologic appearance and ETV6 gene (12p13) rearrangement as secretory carcinoma of the breast. Prior to its recognition, MASC cases were commonly labeled acinic cell carcinoma and adenocarcinoma, not otherwise specified. Despite distinctive histologic features, MASC may be difficult to distinguish from other salivary gland tumors, in particular zymogen-poor acinic cell carcinoma and low-grade salivary duct carcinoma. Although characteristic morphologic and immunohistochemical features form the basis of a diagnosis of MASC, the presence of an ETV6-NTRK3 gene fusion is confirmatory. Given its recent recognition the true prognostic import of MASC is not yet clearly defined.

scholarly journals Acinic cell carcinoma of the salivary glands: A literature review

2009 ◽  
Vol 2 (1) ◽  
pp. 259-264 ◽  
Author(s):  
Nabil Al-Zaher ◽  
Amani Obeid ◽  
Suhail Al-Salam ◽  
Bassam Sulaiman Al-Kayyali
Keyword(s):  
Literature Review ◽  
Cell Carcinoma ◽  
Salivary Glands ◽  
Acinic Cell Carcinoma ◽  
Acinic Cell

scholarly journals A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Anthony C. Nichols ◽  
Michelle Chan-Seng-Yue ◽  
John Yoo ◽  
Sumit K. Agrawal ◽  
Maud H. W. Starmans ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Large Scale ◽  
Cellular Proliferation ◽  
Genetic Characterization ◽  
Distant Metastases ◽  
Acinic Cell Carcinoma ◽  
Nonsynonymous Mutation ◽  
Acinic Cell

We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.

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