scholarly journals A Clinicopathological Approach to Odontogenic Cysts: the Role of Cytokeratin 17 and bcl2 Immunohistochemistry in Identifying Odontogenic Keratocysts

2020 ◽  
Vol 26 (4) ◽  
pp. 2613-2620
Author(s):  
Dorottya Cserni ◽  
Tamás Zombori ◽  
András Vörös ◽  
Anette Stájer ◽  
Annamária Rimovszki ◽  
...  
Keyword(s):  
Odontogenic Cysts ◽  
Cytokeratin 17 ◽  
Odontogenic Keratocysts

scholarly journals Role of Cytokeratin-7 in the pathogenesis of odontogenic cysts - an immunohistochemical study

2019 ◽  
Author(s):  
Pulin Saluja ◽  
Manpreet Arora ◽  
Aparna Dave ◽  
Vishwa Prakash Shetty ◽  
Charu Khurana ◽  
...  
Keyword(s):  
Tooth Development ◽  
Statistical Significance ◽  
Odontogenic Cysts ◽  
P Value ◽  
Cytokeratin 7 ◽  
Chi Square ◽  
Odontogenic Keratocysts ◽  
Dentigerous Cysts ◽  
Well Differentiated

Introduction. Odontogenic cysts are distinct entities and quite a common occurrence in the jaw bones. These are individual lesions which arise from the same odontogenic apparatus but with varying pathogenesis. Cytokeratins are integral components in tooth development and are expressed across the odontogenic tissues in physiological and pathological states. Aim. To elucidate the role of cytokeratin-7 in the pathogenesis of odontogenic cysts by immunohistochemistry Method. Cytokeratin-7 (CK-7) was assessed in 39 cases of odontogenic lesions retrieved from the archival files which included 15 cases of Dentigerous cysts (DC), 12 cases of Odontogenic keratocysts (OKC) and 12 cases of Radicular cysts (RC) and also 8 cases of control specimens. Statistical analysis. Results obtained were statistically analyzed using chi-square test to assess the association between different odontogenic cysts used in this study and Cytokeration-7 staining. The difference was considered to be of statistical significance if the p value was ≤ 0.05. Results. CK7 expression was maximum in dentigerous cycts (66.66%) followed by radicular cysts (41.66%) and odontogenic keratocysts (16.6%). On evaluation of staining and expression pattern, highest positivity is shown in Dentigerous cysts and the positivity is seen in suprabasal (60%) and superficial layers (40%) whereas radicular cysts and odontogenic keratocysts showed positivity in superficial and spinous layers. Conclusion. Cytokeratin-7 expression correlates with the degree of differentiation of the epithelium. So the cysts with a well-differentiated epithelium (RC and DC) express CK-7, while the cysts with a less well-differentiated epithelium (OKC) show slight positivity. Thus it can be useful to differentiate OKC from DC and RC.

scholarly journals Hypoxia and proangiogenic proteins in human ameloblastoma

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Raíssa Pinheiro de Mendonça ◽  
Karolyny Martins Balbinot ◽  
Beatriz Voss Martins ◽  
Maria Sueli da Silva Kataoka ◽  
Ricardo Alves Mesquita ◽  
...  
Keyword(s):  
Aggressive Behaviour ◽  
Tumour Progression ◽  
Tumour Microenvironment ◽  
Odontogenic Cysts ◽  
Biological Behaviour ◽  
Odontogenic Tumours ◽  
Anti Vegf ◽  
The Mean

Abstract Ameloblastomas are epithelial odontogenic tumours that, although benign, are locally invasive and may exhibit aggressive behaviour. In the tumour microenvironment, the concentration of oxygen is reduced, which leads to intratumoral hypoxia. Under hypoxia, the crosstalk between the HIF-1α, MMP-2, VEGF, and VEGFR-2 proteins has been associated with hypoxia-induced angiogenesis, leading to tumour progression and increased invasiveness. This work showcases 24 ameloblastoma cases, 10 calcifying odontogenic cysts, and 9 dental follicles, used to investigate the expression of these proteins by immunohistochemistry. The anti-HIF-1α, anti-MMP-2, anti-VEGF, and anti-VEGFR-2 primary antibodies are used in this work. The results have been expressed by the mean grey value after immunostaining in images acquired with an objective of 40×. The ameloblastoma samples showed higher immunoexpression of HIF-1α, MMP-2, VEGF, and VEGFR-2 when compared to the dental follicles and calcifying odontogenic cysts. Ameloblastomas show a higher degree of expression of proteins associated with intratumoral hypoxia and proangiogenic proteins, which indicates the possible role of these proteins in the biological behaviour of this tumour.

Immunolocalization of PTCH Protein in Odontogenic Cysts and Tumors

2002 ◽  
Vol 81 (11) ◽  
pp. 757-760 ◽  
Author(s):  
D.C. Barreto ◽  
A.E. Bale ◽  
L. De Marco ◽  
R.S. Gomez
Keyword(s):  
Basal Cell ◽  
Tumor Suppression ◽  
Protein Product ◽  
Odontogenic Tumors ◽  
Odontogenic Cysts ◽  
Odontogenic Keratocysts ◽  
Basal Cell Carcinomas ◽  
Different Types ◽  
Embryologic Development

The human patched gene ( PTCH) functions in both embryologic development and tumor suppression. PTCH mutations have been found in odontogenic keratocysts. However, the expression and localization of the protein product of the gene have not been determined in odontogenic tumors and cysts. We investigated 68 odontogenic lesions by immunohistochemistry, and compared their PTCH expression with that in basal cell carcinomas. All odontogenic lesions, including two keratocysts with truncating mutations, were positive for PTCH. Different types of lesions had different amounts of staining. Lack of staining was noted in the majority of basal cell carcinomas. Taken together, these data suggest that odontogenic keratocysts arise with heterozygous mutations of the PTCH gene.

The role of endotoxin and cytokines in the pathogenesis of odontogenic cysts

1996 ◽  
Vol 41 (6) ◽  
pp. 523-531 ◽  
Author(s):  
S. Meghji ◽  
W. Qureshi ◽  
B. Henderson ◽  
M. Harris
Keyword(s):  
Odontogenic Cysts

scholarly journals Frequency of Different Odontogenic Cysts in Patients Visiting Oral Maxillofacial Department of Dental Hospitals in Peshawar

2015 ◽  
Vol 1 (2) ◽  
pp. 29-35
Author(s):  
Sofia Haider Durrani ◽  
Waqar -Ul- Nisa ◽  
Saira Afridi
Keyword(s):  
Relative Frequency ◽  
Odontogenic Cysts ◽  
Anterior Maxilla ◽  
Odontogenic Keratocysts ◽  
Posterior Maxilla ◽  
Dentigerous Cysts ◽  
History Of

Background and Objective:The aim of this study was to investigate the relative frequency of odontogenic cysts in two local dental college hospitals.Methodology:In this study 90 cysts from both jaws, treated at Khyber College of Dentistry and Sardar Begum Dental College from March 2008 to March 2013 were analyzed in order to evaluate the incidence of these cysts.Results:Case history of 52 males and 38 females were analyzed. The age of patients varied from 07 to 70 years, with a mean age of 26.4±13.89. In this 5-year study of odontogenic cysts, 48 were radicular cysts, 22 were odontogenic keratocysts and 20 were dentigerous cysts. Out of these 46 cysts were present in the maxilla and 44 in the mandible. In the maxilla 46.7%were present in the anterior maxilla and 4.4% in the posterior maxilla. In the mandible 35.6% were present in the posterior mandible and 13.3% in the anterior mandible.Conclusion:From the findings of this study we conclude that odontogenic cysts were mostly inflammatory in nature i.e. the radicular cysts and was followed by odontogenic keratocysts. Majority of the cysts were located in the anterior maxilla and posterior mandible regions. The male predilection was higher as compared to females.

scholarly journals Localization of a Peripheral Residual Cyst: Diagnostic Role of CT Scan

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Anshuman Jamdade ◽  
Gopakumar R. Nair ◽  
Madhur Kapoor ◽  
Neeta Sharma ◽  
Arya Kundendu
Keyword(s):  
Ct Scan ◽  
Odontogenic Cysts ◽  
Radicular Cyst ◽  
Diagnostic Role

The termresidual cystis used most often for retained radicular cyst from teeth that has been removed. Residual cysts are among most common cysts of the jaws. The location of all odontogenic cysts is usually intraosseous. The peripheral (extraosseous) presentations are rare. The peripheral presentation of residual cyst has never been reported in the literature. In this article, the role of CT in diagnosing an unusual peripheral presentation of a residual cyst is discussed.

scholarly journals p63 Expression in Solitary and Syndromic Odontogenic Keratocysts: An Immunohistochemical Study

Proceedings ◽  
2019 ◽  
Vol 35 (1) ◽  
pp. 29
Author(s):  
Luconi ◽  
Togni ◽  
Giannatempo ◽  
Caponio ◽  
Mascitti ◽  
...  
Keyword(s):  
Immunohistochemical Study ◽  
Odontogenic Keratocyst ◽  
Odontogenic Cysts ◽  
Odontogenic Keratocysts

In the last years, the classification of odontogenic cysts and tumors has been highly debated, especially regarding odontogenic keratocyst (OKC). [...]

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