Preparation and determination of optical purity of γ-lysine modified peptide nucleic acid analogues

2012 ◽  
Vol 35 (3) ◽  
pp. 517-522 ◽  
Author(s):  
Hu Huang ◽  
Goon Ho Joe ◽  
Sung Rok Choi ◽  
Su Nam Kim ◽  
Yong Tae Kim ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Optical Purity ◽  
Nucleic Acid Analogues

PNA-nucleic acid complexes. Structure, stability and dynamics

1996 ◽  
Vol 29 (4) ◽  
pp. 369-394 ◽  
Author(s):  
Magdalena Eriksson ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Hydrolytic Enzymes ◽  
Living Cells ◽  
Structure Stability ◽  
Peptide Chemistry ◽  
Cell Extracts ◽  
Phosphate Backbone ◽  
A Chain ◽  
Nucleic Acid Analogues

Growing interest in gene targeting drugs has inspired the development of a multitude of nucleic acid analogues, many of which feature substitutions in the phosphodiester moiety of the backbone (reviewed by Mesmaeker et al. 1995 and Nielsen, 1995). Peptide nucleic acid (PNA) is an example of a more radical redesign of DNA. The entire sugar-phosphate backbone is substituted by a chain of peptide-like N-(2-aminoethyl)glycine units so that an achiral and uncharged DNA-mimic is obtained (Fig. 1; Nielsen et al. 1991). The synthesis is based on standard peptide chemistry (Christensen et al. 1995) and has been automated. PNA can relatively easily be modified to include modifications of the backbone as well as of the bases (Hyrup & Nielsen, 1996). PNA is chemically stable and, in contrast to natural nucleic acids and peptides, PNA is expected to remain intact in living cells since it is not a substrate for natural hydrolytic enzymes and is not degraded by cell extracts (Demidov et al. 1994).

Electrochemical Determination of Hg2+Using Electrodes Modified with Peptide Nucleic Acid

2016 ◽  
Vol 163 (14) ◽  
pp. B667-B672 ◽  
Author(s):  
Agnieszka Bala ◽  
Krzysztof Zalewski ◽  
Łukasz Górski
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Electrochemical Determination

Anti-Hepatitis B Virus Activity of New Pyrimidine and Adenine Peptide Nucleic Acid Analogues

2009 ◽  
Vol 64 (1-2) ◽  
pp. 6-10 ◽  
Author(s):  
Wafaei A. Zayat ◽  
Wael A. El-Sayed ◽  
Adel A.-H. Abdel-Rahman
Keyword(s):  
Hepatitis B Virus ◽  
Nucleic Acid ◽  
Hepatitis B ◽  
Peptide Nucleic Acid ◽  
Coupling Reaction ◽  
Infectivity Assay ◽  
Virus Activity ◽  
B Virus ◽  
Nucleic Acid Analogues ◽  
Adenine Derivatives

A number of N-substituted thymine and adenine derivatives, 2a, b and 3a, b, were synthesized by the coupling reaction of 1-bromo-2,2-diethoxyethane with the corresponding base. The corresponding peptide nucleic acid (PNA) analogues, N-substituted ethylamino-3-hydroxypropanoate derivatives 5a, b and ethylamino-3-hydroxybutanoate derivatives 6a, b, were synthesized from the corresponding 2-[3,4-dihydro-5-methyl-2,4-dioxopyrimidin-1(2H)- yl]-acetaldehyde (3a) and 2-[6-amino-4H-purin-9(5H)-yl]-acetaldehyde (3b), respectively. The synthesized compounds were tested for their antiviral activity against hepatitis B virus (HBV). The plaque reduction infectivity assay was used to determine the virus count reduction as a result of the treatment with the tested compounds.

3-(Aminomethyl)-2-(carboxymethyl)isoxazolidinyl nucleosides: building blocks for peptide nucleic acid analogues

2007 ◽  
Vol 18 (13) ◽  
pp. 1517-1520 ◽  
Author(s):  
Pedro Merino ◽  
Tomás Tejero ◽  
Juan Matés ◽  
Ugo Chiacchio ◽  
Antonino Corsaro ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Building Blocks ◽  
Nucleic Acid Analogues

Dual-recognition-based determination of ctDNA via the clamping function of peptide nucleic acid and terminal protection of small-molecule-linked DNA

The Analyst ◽  
2020 ◽  
Vol 145 (23) ◽  
pp. 7603-7608
Author(s):  
Chaohui Chen ◽  
Rongxiang He ◽  
Zhengtao Zhang ◽  
Yong Chen
Keyword(s):  
Nucleic Acid ◽  
Small Molecule ◽  
Peptide Nucleic Acid ◽  
Circulating Tumor Dna ◽  
Fluorescent Biosensor ◽  
Tumor Dna

A new dual-recognition fluorescent biosensor for circulating tumor DNA (ctDNA) detection has been developed, which combines the clamping function of peptide nucleic acid (PNA) and terminal protection of small-molecule-linked DNA (TPSMLD).

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