Deciphering the nexus between the tumor immune microenvironment and DNA methylation in subgrouping estrogen receptor-positive breast cancer

Breast Cancer ◽  
2021 ◽  
Author(s):  
Xiao-Qiong Chen ◽  
Fan Zhang ◽  
Fu-Hui Xiao ◽  
Yu Peng
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Estrogen Receptor ◽  
Immune Microenvironment ◽  
Tumor Immune Microenvironment ◽  
Estrogen Receptor Positive ◽  
Positive Breast Cancer

scholarly journals DNA Methylation Markers Predict Outcome in Node-Positive, Estrogen Receptor-Positive Breast Cancer with Adjuvant Anthracycline-Based Chemotherapy

2008 ◽  
Vol 15 (1) ◽  
pp. 315-323 ◽  
Author(s):  
Oliver Hartmann ◽  
Frédérique Spyratos ◽  
Nadia Harbeck ◽  
Dimo Dietrich ◽  
Anne Fassbender ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Estrogen Receptor ◽  
Node Positive ◽  
Estrogen Receptor Positive ◽  
Positive Breast Cancer

scholarly journals Toronto Workshop on Late Recurrence in Estrogen Receptor–Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Ryan J O Dowling ◽  
Kevin Kalinsky ◽  
Daniel F Hayes ◽  
Francois-Clement Bidard ◽  
David W Cescon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
International Workshop ◽  
Recurrence Risk ◽  
Late Recurrence ◽  
Current Understanding ◽  
Breast Cancer Patients ◽  
Related Factors ◽  
Estrogen Receptor Positive ◽  
Positive Breast Cancer

Abstract Disease recurrence (locoregional, distant) exerts a significant clinical impact on the survival of estrogen receptor–positive breast cancer patients. Many of these recurrences occur late, more than 5 years after original diagnosis, and represent a major obstacle to the effective treatment of this disease. Indeed, methods to identify patients at risk of late recurrence and therapeutic strategies designed to avert or treat these recurrences are lacking. Therefore, an international workshop was convened in Toronto, Canada, in February 2018 to review the current understanding of late recurrence and to identify critical issues that require future study. In this article, the major issues surrounding late recurrence are defined and current approaches that may be applicable to this challenge are discussed. Specifically, diagnostic tests with potential utility in late-recurrence prediction are described as well as a variety of patient-related factors that may influence recurrence risk. Clinical and therapeutic approaches are also reviewed, with a focus on patient surveillance and the implementation of extended endocrine therapy in the context of late-recurrence prevention. Understanding and treating late recurrence in estrogen receptor–positive breast cancer is a major unmet clinical need. A concerted effort of basic and clinical research is required to confront late recurrence and improve disease management and patient survival.

Late Recurrences After Estrogen Receptor–Positive Breast Cancer

JAMA Oncology ◽  
2020 ◽  
Vol 6 (2) ◽  
pp. 301
Author(s):  
Steven A. Narod ◽  
Vasily Giannakeas ◽  
Victoria Sopik
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptor Positive ◽  
Positive Breast Cancer

Decreased nocturnal plasma melatonin peak in patients with estrogen receptor positive breast cancer

Science ◽  
1982 ◽  
Vol 216 (4549) ◽  
pp. 1003-1005 ◽  
Author(s):  
L Tamarkin ◽  
D Danforth ◽  
A Lichter ◽  
E DeMoss ◽  
M Cohen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Plasma Melatonin ◽  
Estrogen Receptor Positive ◽  
Positive Breast Cancer
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