Assessment of left ventricular contraction patterns using gated SPECT MPI to predict cardiac resynchronization therapy response

2017 ◽  
Vol 25 (6) ◽  
pp. 2029-2038 ◽  
Author(s):  
Ningchao Tao ◽  
Yuanhao Qiu ◽  
Haipeng Tang ◽  
Zhiyong Qian ◽  
Hongping Wu ◽  
...  
Keyword(s):  
Cardiac Resynchronization Therapy ◽  
Gated Spect ◽  
Therapy Response ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Ventricular Contraction ◽  
Resynchronization Therapy ◽  
Spect Mpi ◽  
Cardiac Resynchronization Therapy Response

scholarly journals Intraventricular synchronism assessment by gated-SPECT myocardial perfusion imaging in cardiac resynchronization therapy. Does cardiomyopathy type influence results?

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Amalia Peix ◽  
Kenia Padrón ◽  
Lázaro O. Cabrera ◽  
Osmín Castañeda ◽  
Danet Milán ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Myocardial Perfusion Imaging ◽  
Gated Spect ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Spect Myocardial Perfusion Imaging ◽  
Resynchronization Therapy ◽  
Spect Mpi ◽  
Spect Myocardial Perfusion

Abstract Purpose To analyze the evolution post-cardiac resynchronization therapy (CRT) in left ventricular non-compaction (LVNC) cardiomyopathy (CM) patients compared to other types of CM, according to clinical and functional variables, by using gated-SPECT myocardial perfusion imaging (MPI). Methods Ninety-three patients (60 ± 11 years, 28% women) referred for pre-CRT assessment were studied and divided into three groups: 1 (non-ischemic CM with LVNC, 11 patients), 2 (ischemic CM, 28 patients), and 3 (non-ischemic CM, 53 patients). All were studied by a 99mTc-MIBI gated-SPECT MPI at rest pre-CRT implantation and 6 ± 1 months after, including intraventricular dyssynchrony assessment by phase analysis. Quality of life was measured by the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Results No differences in sex, atherosclerotic risk factors other than smoking habit, and MLHFQ results were found among groups. LVNC CM patients were younger, with greater QRS width and lower left ventricular ejection fraction (LVEF) at baseline, but the differences were not significant. No significant differences were found at baseline regarding ventricular function, although end-systolic volume was slightly higher in LVNC CM patients. Mean SRS was significantly higher (p < 0.0001) in ischemic patients (14.9) versus non-ischemic ones (8.7 in group 1 and 9 in group 2). At baseline, LVNC CM patients were significantly more dyssynchronous: Their phase standard deviation (PSD) was higher (89.5° ± 14.2°) versus groups 2 (65.2° ± 23.3°) and 3 (69.7° ± 21.7°), p = 0.007. Although the quality of life significantly improved in all groups, non-ischemic patients (with or without LVNC) showed a higher LVEF increase and volumes reduction at 6 months post-CRT. Dyssynchrony reduced post-CRT in all groups. Nevertheless, those more dyssynchronous at baseline (LVNC CM) exhibited the most significant intraventricular synchronism improvement: PSD was reduced from 89.5° ± 14.2° at baseline to 63.7° ± 20.5° post-CRT (p = 0.028). Six months post-CRT, 89% of patients were responders: 11 (100%) of those with LVNC CM, 25 (86%) of those with ischemic CM, and 47 (89%) of patients with non-ischemic CM. No patient with LVNC CM had adverse events during the follow-up. Conclusion CRT contributes to a marked improvement in non-ischemic CM patients with non-compaction myocardium. Phase analysis in gated-SPECT MPI is a valuable tool to assess the response to CRT.

scholarly journals The use of mechanical dyssynchrony for predicting response to cardiac resynchronization therapy in patients with non-ischemic cardiomyopathy

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
V Saushkin ◽  
YV Varlamova ◽  
AI Mishkina ◽  
DI Lebedev ◽  
SV Popov ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Myocardial Perfusion ◽  
Cardiac Resynchronization Therapy ◽  
Ischemic Cardiomyopathy ◽  
Gated Spect ◽  
Mechanical Dyssynchrony ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Crt Response

Abstract Funding Acknowledgements Type of funding sources: None. Aim/Introduction: Assessment of mechanical dyssynchrony by myocardial perfusion gated-SPECT in patients with non-ischemic cardiomyopathy for predict response to cardiac resynchronization therapy (CRT). Materials and Methods  We examined 32 patients with non-ischemic cardiomyopathy before and six months after CRT.  Left ventricular mechanical dyssynchrony and contractility were assessed for all patients by myocardial perfusion gated-SPECT. The phase standard deviation (PSD), histogram bandwidth (HBW), phase histogram skewness (S) and phase histogram kurtosis (K) were used as an indicator of mechanical dyssynchrony for the both ventricles.  Results  Mechanical dyssynchrony of both ventricles before CRT was increased in all patients. Median value PSD 53°(41-61°), HBW 176°(136-202°), S 1,62(1,21-1,89), K 2,81(1,21-3,49). Six months after CRT 22(68%) respondents were identified. We divided the patients into two groups (responders and non-responders) and compared phase parameters. It was found that the PSD (44°(35-54°)) and HBW (158°(118-179°) in the responders were significantly lower than in the non-responders (PSD (68°(58-72°); HBW (205°(199-249°)). The value of phase histogram skewness and kurtosis in responders were significantly higher (Responders: S 1,77(1,62-2,02); K 3,03(2,60-3,58). Non-responders: S 1,21(0,93-1,31); K 1,21(0,19-1,46)).  We found that all four indicators of mechanical dyssynchrony can predict CRT response according to the results of univariate logistic regression analysis. Moreover, It was found that only phase histogram kurtosis (OR = 1.196, 95% CI 1.04-1.37) is an independent predictor of CRT response according to multivariate logistic regression. Conclusion  Radionuclide assessment of mechanical dyssynchrony may be the optimal diagnostic method for selecting patients with non-ischemic cardiomyopathy on CRT.

Has Mechanical Dyssynchrony Still a Role in Predicting Cardiac Resynchronization Therapy Response?

2010 ◽  
Vol 27 (7) ◽  
pp. 831-838 ◽  
Author(s):  
Maria Cristina Porciani ◽  
Francesco Cappelli ◽  
Laura Perrotta ◽  
Marco Chiostri ◽  
Carmelo M. Rao ◽  
...  
Keyword(s):  
Cardiac Resynchronization Therapy ◽  
Therapy Response ◽  
Mechanical Dyssynchrony ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Cardiac Resynchronization Therapy Response

QRS area as a predictor of cardiac resynchronization therapy response: a systematic review and meta‐analysis

2022 ◽  
Author(s):  
Nithi Tokavanich ◽  
Narut Prasitlumkum ◽  
Wimwipa Mongkonsritragoon ◽  
Angkawipa Trongtorsak ◽  
Wisit Cheungpasitporn ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiac Resynchronization Therapy ◽  
Meta Analysis ◽  
Therapy Response ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Cardiac Resynchronization Therapy Response

scholarly journals Development of a biomarker panel to predict cardiac resynchronization therapy response: Results from the SMART-AV trial

Heart Rhythm ◽  
2019 ◽  
Vol 16 (5) ◽  
pp. 743-753
Author(s):  
Francis G. Spinale ◽  
Timothy E. Meyer ◽  
Craig M. Stolen ◽  
Jennifer E. Van Eyk ◽  
Michael R. Gold ◽  
...  
Keyword(s):  
Cardiac Resynchronization Therapy ◽  
Therapy Response ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Biomarker Panel ◽  
Cardiac Resynchronization Therapy Response
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