QRS area as a predictor of cardiac resynchronization therapy response: a systematic review and meta‐analysis

2022 ◽  
Author(s):  
Nithi Tokavanich ◽  
Narut Prasitlumkum ◽  
Wimwipa Mongkonsritragoon ◽  
Angkawipa Trongtorsak ◽  
Wisit Cheungpasitporn ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiac Resynchronization Therapy ◽  
Meta Analysis ◽  
Therapy Response ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Cardiac Resynchronization Therapy Response

scholarly journals Septal flash as a predictor of cardiac resynchronization therapy response: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Sadie Bennett ◽  
Jacopoa Tafuro ◽  
Simon Duckett ◽  
Grant Heatlie ◽  
Ashish Patwala ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiac Resynchronization Therapy ◽  
Meta Analysis ◽  
Therapy Response ◽  
Symptomatic Improvement ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Septal Flash ◽  
Crt Response

Background: Cardiac resynchronization therapy (CRT) in heart failure patients has been shown to improve patient outcomes in some but not all patients. A few studies have identified that septal flash on imaging is associated with response to CRT but there has yet to be systematic review to evaluate consistency of the finding across the literature. Methods: A search of MEDLINE and EMBASE was conducted to identify studies which evaluate septal flash and its association with CRT response. Studies that met the inclusion criteria were statistically pooled with random-effects meta-analysis and heterogeneity was assessed using the I statistic. Results: A total of nine studies were included with 2,307 participants (mean age 76 years, 67% male). Septal flash on imaging before CRT implantation was seen in 53% of patients and the proportion of CRT responders from the included studies varied from 52% to 77%. In patients who were CRT responders, septal flash was seen in 40% of patients compared to 10% in those deemed to be CRT non-responders. Meta-analysis of the eight studies suggests that the presence of septal flash at pre-implant was associated with an increased likelihood of CRT response (RR 2.55 95%CI 2.04-3.19, p<0.001, I2=51%). Septal flash was also reported to be associated with left ventricular reverse remodelling but the association with survival and symptomatic improvement was less clear. Conclusions: Septal flash is a well-defined and distinctive contraction pattern which is consistently associated with CRT response and should be evaluated when assessing for appropriateness of CRT device.

Has Mechanical Dyssynchrony Still a Role in Predicting Cardiac Resynchronization Therapy Response?

2010 ◽  
Vol 27 (7) ◽  
pp. 831-838 ◽  
Author(s):  
Maria Cristina Porciani ◽  
Francesco Cappelli ◽  
Laura Perrotta ◽  
Marco Chiostri ◽  
Carmelo M. Rao ◽  
...  
Keyword(s):  
Cardiac Resynchronization Therapy ◽  
Therapy Response ◽  
Mechanical Dyssynchrony ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Cardiac Resynchronization Therapy Response

scholarly journals Development of a biomarker panel to predict cardiac resynchronization therapy response: Results from the SMART-AV trial

Heart Rhythm ◽  
2019 ◽  
Vol 16 (5) ◽  
pp. 743-753
Author(s):  
Francis G. Spinale ◽  
Timothy E. Meyer ◽  
Craig M. Stolen ◽  
Jennifer E. Van Eyk ◽  
Michael R. Gold ◽  
...  
Keyword(s):  
Cardiac Resynchronization Therapy ◽  
Therapy Response ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Biomarker Panel ◽  
Cardiac Resynchronization Therapy Response

scholarly journals P5475De novo implantation vs. upgrade cardiac resynchronization therapy: a systematic review and meta-analysis

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
A. Kosztin ◽  
M. Vamos ◽  
D. Aradi ◽  
R. Schwertner ◽  
A. Kovacs ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiac Resynchronization Therapy ◽  
Meta Analysis ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy
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