scholarly journals 18F-FDG PET/CMR in cardiac sarcoidosis: A wild card in the deck?

2020 ◽  
Author(s):  
Carmela Nappi ◽  
Andrea Ponsiglione ◽  
Massimo Imbriaco ◽  
Alberto Cuocolo
Keyword(s):  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
Wild Card ◽  
18F Fdg

scholarly journals The prevalence of cardiac sarcoidosis is underestimated: [18F]FDG-PET is the answer

2021 ◽  
Vol 22 (Supplement_3) ◽  
Author(s):  
J Borges-Rosa ◽  
M Oliveira-Santos ◽  
R Silva ◽  
J Lopes De Almeida ◽  
L Goncalves ◽  
...  
Keyword(s):  
Heart Failure ◽  
Fdg Pet ◽  
Cardiac Involvement ◽  
Cardiac Sarcoidosis ◽  
Clinical Manifestations ◽  
European Population ◽  
Response To Therapy ◽  
Histological Diagnosis ◽  
18F Fdg

Abstract Funding Acknowledgements Type of funding sources: None. Background Overt cardiac involvement is reported in 5% of patients with sarcoidosis, although autopsy and imaging studies suggest higher prevalence, worldwide variation. The role of 18F-fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) in non-invasive diagnosis and follow-up has increased in the last decade. Purpose Our goal is to describe the prevalence, clinical manifestations and outcomes of cardiac sarcoidosis (CS), diagnosed through [18F]FDG-PET, in a southern European population. Methods We included all patients with histological diagnosis of extracardiac sarcoidosis screened with [18F]FDG-PET between 2009 and 2020. We collected data on clinical manifestations, cardiac magnetic resonance (CMR) results, and mortality outcomes and compared those with and without cardiac involvement. We applied the criteria for the diagnosis of CS from Heart Rhythm Society. Results Of the 400 patients screened with [18F]FDG-PET, 128 had a histological diagnosis of extracardiac sarcoidosis (54.7% females, mean age 51.0 ± 14.2 years). None underwent endomyocardial biopsy. Ten patients had a pattern of [18F]FDG uptake consistent with CS defined as diffuse (n = 5), focal (n = 3), and focal on diffuse (n = 2). Of the 128 patients, 14 also underwent CMR, which identified 2 subjects with positive findings in both modalities and 3 additional patients: focal (n = 1), multifocal mid-wall (n = 2), focal mid-wall (n = 2), and multifocal subepicardial (n = 1) delayed gadolinium enhancement. Overall, 13 patients (10.2%) fulfilled the criteria for probable CS (53.8% female, mean age 56.2 ± 12.6 years), all with multiorgan involvement, mostly lung and lymph nodes (each 92%), followed by skin and central nervous system (each 15%). Median left ventricle ejection fraction was 62% [55-65] and there were cardiac manifestations of CS in 6 patients (46%): sick sinus syndrome (n = 2), complete heart block (n = 1), frequent premature ventricular complexes (n = 1), ventricular tachycardia plus heart failure (n = 1), and bifascicular block plus heart failure (n = 1). Eleven patients (85%) with probable CS were medicated with immunosuppressant drugs: corticosteroids (n = 9), methotrexate (n = 4), and azathioprine (n = 2). Four patients with previous [18F]FDG screening were revaluated after treatment, each showing no cardiac uptake.  After a mean follow-up of 4.0 ± 1.0 years, mortality was three-fold higher in patients with cardiac involvement, despite the absence of statistical significance (15% vs. 5%, P = 0.151). Conclusions In a southern European population with histological extracardiac sarcoidosis, the prevalence of cardiac involvement was 10.2%, most asymptomatic. [18F]FDG-PET improves the diagnostic yield and plays an important role in monitoring response to therapy. The higher mortality trend in those with CS needs to be ascertained in longer follow-up.

scholarly journals P307Efficacy and adverse effects of strict pretest preparation for 18F-FDG PET/CT for assessment of cardiac sarcoidosis

2019 ◽  
Vol 20 (Supplement_3) ◽  
Author(s):  
H Ohira ◽  
K Yoshinaga ◽  
S Sakiyama ◽  
T Nakaya ◽  
J Nakamura ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Effectiveness of prolonged fasting 18f-FDG PET-CT in the detection of cardiac sarcoidosis

2009 ◽  
Vol 16 (5) ◽  
pp. 801-810 ◽  
Author(s):  
Rumman Langah ◽  
Kenneth Spicer ◽  
Mulugeta Gebregziabher ◽  
Leonie Gordon
Keyword(s):  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
Prolonged Fasting ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

The Utility of Whole Body 18F-FDG PET-CT in Diagnosing Isolated Cardiac Sarcoidosis: The Western Australian Cardiac Sarcoid Study

2020 ◽  
Vol 29 (1) ◽  
pp. e1-e6 ◽  
Author(s):  
Lauren Giudicatti ◽  
James Marangou ◽  
David Nolan ◽  
Lawrence Dembo ◽  
Jay Baumwol ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
Whole Body ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Western Australian

scholarly journals The Evaluation of Cardiac Sarcoidosis with 18F-FDG PET

2015 ◽  
Vol 44 (2) ◽  
pp. 92-93 ◽  
Author(s):  
Z. Al-Faham ◽  
P. Jolepalem ◽  
C. Y. Oliver Wong
Keyword(s):  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
18F Fdg

scholarly journals 18F-FDG-PET in Finnish patients with clinical suspicion of cardiac sarcoidosis: Female sex and history of atrioventricular block increase the prevalence of positive PET findings

2017 ◽  
Vol 26 (2) ◽  
pp. 394-400 ◽  
Author(s):  
Heikki Tuominen ◽  
Atte Haarala ◽  
Antti Tikkakoski ◽  
Pasi Korkola ◽  
Mika Kähönen ◽  
...  
Keyword(s):  
Atrioventricular Block ◽  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
Clinical Suspicion ◽  
Female Sex ◽  
History Of ◽  
18F Fdg

scholarly journals A dual tracer 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT pilot study for detection of cardiac sarcoidosis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Lars C. Gormsen ◽  
Ate Haraldsen ◽  
Stine Kramer ◽  
Andre H. Dias ◽  
Won Yong Kim ◽  
...  
Keyword(s):  
Pilot Study ◽  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Dual Tracer

scholarly journals 18F-FDG-PET CT Findings in a Patient with Early-phase Cardiac Sarcoidosis

2013 ◽  
Vol 52 (23) ◽  
pp. 2681-2681 ◽  
Author(s):  
Taku Inohara ◽  
Toru Egashira ◽  
Jun Fujita ◽  
Keiichi Fukuda
Keyword(s):  
Fdg Pet ◽  
Early Phase ◽  
Cardiac Sarcoidosis ◽  
Ct Findings ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct
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