Design and Effectiveness of the Youth Engaged Strategies for Changing Adolescent Norms! (YES-CAN!) Program for Reducing Skin Cancer Risk

(1) The incidence of skin cancer is increasing in the United States (US) despite scientific advances in our understanding of skin cancer risk factors and treatments. In vitro and in vivo studies have provided evidence that suggests that certain photosensitizing medications (PSMs) increase skin cancer risk. This review summarizes current epidemiological evidence on the association between common PSMs and skin cancer. (2) A comprehensive literature search was conducted to identify meta-analyses, observational studies and clinical trials that report on skin cancer events in PSM users. The associated risks of keratinocyte carcinoma (squamous cell carcinoma and basal cell carcinoma) and melanoma are summarized, for each PSM. (3) There are extensive reports on antihypertensives and statins relative to other PSMs, with positive and null findings, respectively. Fewer studies have explored amiodarone, metformin, antimicrobials and vemurafenib. No studies report on the individual skin cancer risks in glyburide, naproxen, piroxicam, chlorpromazine, thioridazine and nalidixic acid users. (4) The research gaps in understanding the relationship between PSMs and skin cancer outlined in this review should be prioritized because the US population is aging. Thus the number of patients prescribed PSMs is likely to continue to rise.

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Measurements of the upper body ultraviolet exposure to golfers: non-melanoma skin cancer risk, and the potential benefits of exposure to sunlight

Photodermatology Photoimmunology & Photomedicine ◽

10.1111/j.1600-0781.2009.00472.x ◽

2009 ◽

Vol 25 (6) ◽

pp. 317-324 ◽

Cited By ~ 14

Author(s):

Nathan J. Downs ◽

Peter W. Schouten ◽

Alfio V. Parisi ◽

Joanna Turner

Keyword(s):

Skin Cancer ◽

Cancer Risk ◽

Upper Body ◽

Ultraviolet Exposure ◽

Skin Cancer Risk ◽

Non Melanoma Skin Cancer ◽

Potential Benefits ◽

Melanoma Skin

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Association of Environmental Arsenic Exposure, Genetic Polymorphisms of Susceptible Genes, and Skin Cancers in Taiwan

BioMed Research International ◽

10.1155/2015/892579 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 15

Author(s):

Ling-I Hsu ◽

Meei-Maan Wu ◽

Yuan-Hung Wang ◽

Cheng-Yeh Lee ◽

Tse-Yen Yang ◽

...

Keyword(s):

Skin Cancer ◽

Cancer Risk ◽

Arsenic Exposure ◽

Skin Carcinogenesis ◽

Glutathione S Transferase ◽

Xenobiotic Detoxification ◽

Skin Cancer Risk ◽

Metabolic Genes ◽

Skin Cancers ◽

And Gender

Deficiency in the capability of xenobiotic detoxification and arsenic methylation may be correlated with individual susceptibility to arsenic-related skin cancers. We hypothesized that glutathione S-transferase (GST M1, T1, and P1), reactive oxygen species (ROS) related metabolic genes (NQO1, EPHX1, and HO-1), and DNA repair genes (XRCC1, XPD, hOGG1, and ATM) together may play a role in arsenic-induced skin carcinogenesis. We conducted a case-control study consisting of 70 pathologically confirmed skin cancer patients and 210 age and gender matched participants with genotyping of 12 selected polymorphisms. The skin cancer risks were estimated by odds ratio (OR) and 95% confidence interval (CI) using logistic regression. EPHX1 Tyr113His, XPD C156A, and GSTT1 null genotypes were associated with skin cancer risk (OR = 2.99, 95% CI = 1.01–8.83; OR = 2.04, 95% CI = 0.99–4.27; OR = 1.74, 95% CI = 1.00–3.02, resp.). However, none of these polymorphisms showed significant association after considering arsenic exposure status. Individuals carrying three risk polymorphisms of EPHX1 Tyr113His, XPD C156A, and GSTs presented a 400% increased skin cancer risk when compared to those with less than or equal to one polymorphism. In conclusion, GSTs, EPHX1, and XPD are potential genetic factors for arsenic-induced skin cancers. The roles of these genes for arsenic-induced skin carcinogenesis need to be further evaluated.

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