Prediction of Non-Linear Pharmacokinetics of Monoclonal Antibodies in Human from Nonclinical Data: Are We There Yet?

2021 ◽  
Author(s):  
Yichao Yu ◽  
Qi-Qi Zhao ◽  
Guo-Fu Li
Keyword(s):  
Monoclonal Antibodies ◽  
Linear Pharmacokinetics ◽  
Non Linear

scholarly journals Non-linear pharmacokinetics of high-dose intravenous verapamil

1997 ◽  
Vol 44 (3) ◽  
pp. 255-260 ◽  
Author(s):  
G. Toffoli ◽  
I. Robieux ◽  
D. Fantin ◽  
M. Gigante ◽  
S. Frustaci ◽  
...  
Keyword(s):  
High Dose ◽  
Linear Pharmacokinetics ◽  
Non Linear

To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics

2015 ◽  
Vol 55 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Sieto Bosgra ◽  
Maria L. H. Vlaming ◽  
Wouter H. J. Vaes
Keyword(s):  
Linear Pharmacokinetics ◽  
Non Linear

Non-Linear Pharmacokinetics of Atomoxetine in Adult Japanese Patients With ADHD

2016 ◽  
Vol 24 (3) ◽  
pp. 490-493
Author(s):  
Atsunori Sugimoto ◽  
Yutaro Suzuki ◽  
Naoki Orime ◽  
Taketsugu Hayashi ◽  
Jun Egawa ◽  
...  
Keyword(s):  
High Performance ◽  
Plasma Concentrations ◽  
Japanese Patients ◽  
High Dose ◽  
Linear Pharmacokinetics ◽  
Blood Samples ◽  
Non Linear ◽  
The Difference ◽  
The Relationship ◽  
Atomoxetine Treatment

Objective: The objective was to reveal the relationship between dose and concentration of atomoxetine. Method: Fifty-five blood samples of 33 patients with ADHD were examined using high-performance liquid chromatography. Results: The plasma concentrations were 53.2 ± 67.0, 298.0 ± 390.5, and 639.3 ± 831.9 ng/mL at doses of 40 mg, 80 mg, and 120 mg, and the concentration/dose were 1.33 ± 1.67, 3.73 ± 4.88, and 5.33 ± 6.93 ng/mL/mg, respectively. Statistical analyses revealed a significant correlation between the concentration and the dose of atomoxetine ( p = .004), and a trending toward significance in the difference in the concentration/dose in the three dosage groups ( p = .064). The concentration/dose at 40 and 80 + 120 mg/day were 1.33 ± 1.67 and 4.22 ± 5.53 ng/mL/mg, the latter was significantly higher than the former ( p = .006), which suggested non-linear pharmacokinetics. Conclusion: Clinicians should carefully titrate in high dose atomoxetine treatment.

Dose-Dependent Bioavailability and CYP3A Inhibition Contribute to Non-Linear Pharmacokinetics of Voriconazole

2016 ◽  
Vol 55 (12) ◽  
pp. 1535-1545 ◽  
Author(s):  
Nicolas Hohmann ◽  
Franziska Kocheise ◽  
Alexandra Carls ◽  
Jürgen Burhenne ◽  
Johanna Weiss ◽  
...  
Keyword(s):  
Linear Pharmacokinetics ◽  
Non Linear ◽  
Dose Dependent

The non-linear pharmacokinetics of prednisone and prednisolone

1988 ◽  
Vol 9 (4) ◽  
pp. 363-376 ◽  
Author(s):  
James J. Ferry ◽  
John G. Wagner
Keyword(s):  
Linear Pharmacokinetics ◽  
Non Linear
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