Modulation of inflammatory mediators by corydalis tuber in LPS-stimulated Raw264.7 cells and its inhibitory effects on carrageenan-stimulated paw edema in rats

Xiao Qing Long Tang essential oil suppresses the production of inflammatory mediators via blocking NF-κB, AP-1, and IRF3 signalling in the lipopolysaccharide-stimulated RAW264.7 cells.

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Inhibitory effects of eutigosides isolated fromEurya emarginata on the inflammatory mediators in RAW264.7 cells

Archives of Pharmacal Research ◽

10.1007/bf02978207 ◽

2005 ◽

Vol 28 (11) ◽

pp. 1244-1250 ◽

Cited By ~ 14

Author(s):

Soo -Yeong Park ◽

Hye -Ja Lee ◽

Weon -Jong Yoon ◽

Gyoung -Jin Kang ◽

Ji -Young Moon ◽

...

Keyword(s):

Inflammatory Mediators ◽

Raw264.7 Cells ◽

Inhibitory Effects

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Design, Synthesis and Pharmacological Evaluation of Novel Antiinflammatory and Analgesic O-Benzyloxime Compounds Derived From Natural Eugenol

Letters in Drug Design & Discovery ◽

10.2174/1570180815666180620145609 ◽

2019 ◽

Vol 16 (10) ◽

pp. 1157-1166

Author(s):

Rodrigo César da Silva ◽

Fabiano Veiga ◽

Fabiana Cardoso Vilela ◽

André Victor Pereira ◽

Thayssa Tavares da Silva Cunha ◽

...

Keyword(s):

Formalin Test ◽

Docking Studies ◽

Paw Edema ◽

Inhibitory Effects ◽

Structural Pattern ◽

Design Synthesis ◽

Drug Candidates ◽

Anti Inflammatory ◽

Analgesic Activities ◽

Cox 1

Background: : A new series of O-benzyloximes derived from eugenol was synthesized and was evaluated for its antinociceptive and anti-inflammatory properties. Methods: : The target compounds were obtained in good global 25-28% yields over 6 steps, which led us to identify compounds (Z)-5,6-dimethoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one-O-(4- (methylthio)benzyloxime (8b), (Z)-5,6-dimethoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one-O-4- bromobenzyloxime (8d) and (Z)-5,6-dimethoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one-O-4- (methylsulfonyl)benzyloxime (8f) as promising bioactive prototypes. Results:: These compounds have significant analgesic and anti-inflammatory effects, as evidenced by formalin-induced mice paw edema and carrageenan-induced mice paw edema tests. In the formalin test, compounds 8b and 8f evidenced both anti-inflammatory and direct analgesic activities and in the carrageenan-induced paw edema, with compounds 8c, 8d, and 8f showing the best inhibitory effects, exceeding the standard drugs indomethacin and celecoxib. Conclusion: : Molecular docking studies have provided additional evidence that the pharmacological profile of these compounds may be related to inhibition of COX enzymes, with slight preference for COX-1. These results led us to identify the new O-benzyloxime ethers 8b, 8d and 8f as orally bioactive prototypes, with a novel structural pattern capable of being explored in further studies aiming at their optimization and development as drug candidates.

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New Truxinic and Truxillic Acid Sucrose Diesters From the Leaves of Trigonostemon honbaensis

Natural Product Communications ◽

10.1177/1934578x21999148 ◽

2021 ◽

Vol 16 (2) ◽

pp. 1934578X2199914

Author(s):

Ninh Khac Ban ◽

Bui Huu Tai ◽

Vu Kim Thu ◽

Phan Van Kiem

Keyword(s):

Nmr Spectra ◽

Raw264.7 Cells ◽

No Production ◽

Inhibitory Effects ◽

Esi Ms ◽

Chemical Structures ◽

Extensive Analysis ◽

Truxillic Acid

A new δ-truxinic acid sucrose diester and a new ε-truxillic acid sucrose diester (named trigohonbanosides E and F) were isolated from the leaves of Trigonostemon honbaensis. Their chemical structures were determined by extensive analysis of their HR-ESI-MS and NMR spectra. At a concentration of 20 µM, trigohonbanosides E and F exhibited weak inhibitory effects on NO production in LPS-activated RAW264.7 cells with inhibitory percentages of 22.7% ± 1.1% and 18.5% ± 1.4%, respectively.

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