Progressive disseminated histoplasmosis in the HIV population in Europe in the HAART era. Case report and literature review

Infection ◽  
2014 ◽  
Vol 42 (4) ◽  
pp. 611-620 ◽  
Author(s):  
R. Martin-Iguacel ◽  
J. Kurtzhals ◽  
G. Jouvion ◽  
S. D. Nielsen ◽  
J. M. Llibre
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

scholarly journals Disseminated Histoplasmosis in an Elderly Man Presented with Fever, Weight loss, Abdominal Pain and Haemoptysis - A Case Report with Literature Review

2011 ◽  
Vol 12 (1) ◽  
pp. 81-85
Author(s):  
Mohammad Robed Amin ◽  
Farzana Shumi ◽  
Hasibuddin Khan ◽  
Syed Ahmed Abdullah ◽  
Shafiul Alam ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Weight Loss ◽  
Abdominal Pain ◽  
Case Report ◽  
Literature Review ◽  
Disseminated Histoplasmosis ◽  
History Of ◽  
Background History ◽  
Recurrent Haemoptysis ◽  
High Index Of Suspicion

An elderly patient presented with prolonged fever, gross weight loss, recurrent haemoptysis and abdominal pain. He had a background history of adrenal tuberculosis with completion of treatment without any obvious improvement. Clinically he was diagnosed as a case of adrenocotical insufficiency. Evaluation including histopathology revealed the diagnosis as disseminated histoplasmosis involving adrenal gland and lungs. The disease is a rarity without any underneath immunosuppression and hence high index of suspicion with appropriate steps for investigation is the key to achieve a diagnosis of disseminated histoplasmosis in Bangladesh. Keyword: . DOI: 10.3329/jom.v12i1.6936J Medicine 2011; 12 : 81-85

scholarly journals Progressive disseminated histoplasmosis with pulmonary and central nervous system involvement: a case report

2021 ◽  
Author(s):  
Matheus Fellipe Nascimento de Souza ◽  
Ana Paula Teixeira da Silva ◽  
Gabriela Santos Bianchin ◽  
Maria Eduarda Angelo de Mendonça Fileti ◽  
Raddib Eduardo Noleto da Nóbrega de Oliveira ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Systemic Disease ◽  
Central Nervous System Involvement ◽  
Tnf Alpha ◽  
Cns Involvement ◽  
Necrosis Factor Alpha ◽  
Adequate Treatment ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

Context: Histoplasmosis (Histoplasma capsulatum) is a systemic disease that affects the lung and immune system1. The severity of histoplasmosis is directly related to the individual’s immune response since it is an opportunistic pathogen2. It is one of the most prevalent infections in immunocompromised patients due to the use of tumor necrosis factor-alpha (TNF-alpha) inhibitors, resulting in a mortality rate of 20%. The evolution to CNS occurs in 5-10% of patients with disseminated symptoms3. Case Report: M.G.M, a woman, 67 years, was admitted with bilateral tonicclonic seizure with focal onset in the right upper limb. The patient had hypertension, diabetes and rheumatoid arthritis, and was use ASA, glibenclamide, hydrochlorothiazide, losartan, amlodipine, adalimumab and methotrexate. Complementary exams were performed that showed lesions suggestive of microangiopathy on cranial CT; nodular lesions in the pulmonary right upper lobe and prominent lymph nodes in the hilum and mediastinum on chest CT; CSF with increased cytology (monomorphonuclear predominance), without glucose consumption. The biopsy of lung lesions identified Histoplasma capsulatum, confirming the diagnosis of progressive disseminated histoplasmosis with pulmonary and CNS involvement. Thus, treatment with amphotericin B was started, however, the patient died. Conclusions: Histoplasmosis is the most prevalent invasive fungal infection in users of TNF-alpha inhibitors. In these cases, the disease can be more aggressive and have a rapid evolution, with CNS involvement - which confers a worse prognosis. Early diagnosis, suspension of the immunomodulator and adequate treatment for infection control are required.

scholarly journals Progressive disseminated histoplasmosis mimicking a flare of systemic lupus erythematosus: a European case report

2016 ◽  
Vol 3 (4) ◽  
Author(s):  
M. L. M. van Doorn-Schepens ◽  
E. J. Peters ◽  
R. M. van Vugt ◽  
J. I. van der Spoel ◽  
K. van Dijk
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis
Sign in / Sign up

Export Citation Format

Share Document