Casein-based hydrogel carrying insulin: preparation, in vitro evaluation and in vivo assessment

2018 ◽  
Vol 49 (6) ◽  
pp. 635-641 ◽  
Author(s):  
Elham Khodaverdi ◽  
Sepehr Maftouhian ◽  
Ali Aliabadi ◽  
Mohammad Hassanzadeh-Khayyat ◽  
Fatemeh Mohammadpour ◽  
...  
Keyword(s):  
Insulin Preparation ◽  
In Vitro Evaluation ◽  
In Vivo Assessment

scholarly journals In vitro and in vivo assessment of biocompatibility of AZ31 alloy as biliary stents: a preclinical approach

2020 ◽  
Author(s):  
Yong Song ◽  
Gaoping Qin ◽  
Lixue Du ◽  
Haitian Hu ◽  
Yong Han
Keyword(s):  
Az31 Alloy ◽  
Biliary Stents ◽  
In Vivo Assessment

scholarly journals In vivo assessment of a single adenine mutation in 5′UTR of Endothelin-1 gene in paediatric cases with severe pulmonary hypertension: an observational study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Abhishek Kumar ◽  
Minati Choudhury ◽  
Sakshi Dhingra Batra ◽  
Kriti Sikri ◽  
Anushree Gupta
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Heart ◽  
Small Sample Size ◽  
Small Sample ◽  
Severe Pulmonary Hypertension ◽  
Endothelin 1 ◽  
Circulating Levels ◽  
In Vivo Assessment

Abstract Objective Endothelin-1 plays an important role in the pathogenesis of severe pulmonary hypertension. The + 139 ‘A’, adenine insertion variant in 5′UTR of edn1 gene has been reported to be associated with increased expression of Endothelin-1 in vitro. The aim of present study was to explore the association of this variant with the circulating levels of Endothelin-1 in vivo using archived DNA and plasma samples from 38 paediatric congenital heart disease (cyanotic and acyanotic) patients with severe pulmonary hypertension. Results The plasma Endothelin-1 levels were highly varied ranging from 1.63 to75.16 pg/ml. The + 139 ‘A’ insertion variant in 5′UTR of edn1 was seen in 8 out of 38 cases with only one acyanotic sample demonstrating homozygosity of inserted ‘A’ allele at + 139 site (4A/4A genotype). The plasma Endothelin-1 levels in children with homozygous variant 3A/3A genotype were comparable in cyanotic and acyanotic groups. Lone 4A/4A acyanotic sample had ET-1 levels similar to the median value of ET-1 associated with 3A/3A genotype and was absent in cyanotic group presumably due to deleterious higher ET-1 levels. The discussed observations, limited by the small sample size, are suggestive of homozygous adenine insertion variant posing a risk in cyanotic babies with Severe Pulmonary Hypertension.

scholarly journals In-vivo assessment of in-vitro killing patterns of Pseudomonas aeruginosa

1985 ◽  
Vol 15 (suppl A) ◽  
pp. 201-206 ◽  
Author(s):  
A. U. Gerber ◽  
C. Feller-Segessenmann
Keyword(s):  
Pseudomonas Aeruginosa ◽  
In Vivo Assessment
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