Enhancement of Aqueous Solubility and Dissolution Profile of Atorvastatin Calcium: In vitro Evaluation of Solid Dispersion

Purpose: The objective of the present study was to formulate solid dispersions (SD) of Atorvastatin calcium to improve the aqueous solubility and dissolution rate to facilitate faster onset of action. Atorvastatin calcium is a lipid lowering agent belonging to BCS-II having low solubility and high permeability.

Combined administration of nicorandil and atorvastatin in patients with acute myocardial infarction after coronary intervention, and its effect on postoperative cardiac systolic function

Purpose: To study the effect of a combination of nicorandil and atorvastatin calcium in patients with acute myocardial infarction after coronary intervention, and its effect on postoperative cardiac systolic function of patients.Methods: Retrospective analysis was performed on 100 patients with acute myocardial infarctiontreated with coronary interventional therapy in The Third Affiliated Hospital of Qiqihaer MedicalUniversity from April 2019 to August 2020. The patients were randomised into control and study groups, with 50 patients in each group. The control group was treated with nicorandil, while the study group was treated with a combination of nicorandil and atorvastatin. Treatment response, cardiac structural indices, cardiac systolic function, blood lipid profiles, quality of life (QLI) score, Barthel Index (BI), Fugl- Meyer assessment (FMA), motor function score, incidence of adverse reactions, and blood pressure changes on days 1, 2, 3 and 4 after surgery, were compared between the two groups.Results: Treatment effectiveness, cardiac systolic function, QLI score, BI index and FMA motor function score in the study group were higher than the corresponding control values (p < 0.05). However, lower cardiac structure indices, blood lipid profiles and incidence of adverse reactions were greater in the study group than in the control group (p < 0.05). No significant disparity in blood pressure was found between the two groups on post-surgery days 1, 2, 3 and 4.Conclusion: The combination of nicorandil and atorvastatin calcium tablets produced better outcomes in patients with acute myocardial infarction after coronary intervention therapy; furthermore, the combination therapy significantly improved the cardiac systolic function of patients.