Emerging role of polyethylene glycol on doxycycline hyclate-incorporated Eudragit RS in situ forming gel for periodontitis treatment

2019 ◽  
Vol 50 (1) ◽  
pp. 81-94 ◽  
Author(s):  
Wai Wai Lwin ◽  
Napaphol Puyathorn ◽  
Setthapong Senarat ◽  
Jongjan Mahadlek ◽  
Thawatchai Phaechamud
Keyword(s):  
Polyethylene Glycol ◽  
Doxycycline Hyclate ◽  
Eudragit Rs ◽  
In Situ Forming ◽  
In Situ Forming Gel

Capsaicin Injectable In-Situ Forming Gels

2012 ◽  
Vol 528 ◽  
pp. 103-106
Author(s):  
Thawatchai Phaechamud ◽  
Sarun Tuntarawongsa
Keyword(s):  
Research Work ◽  
Local Drug Delivery ◽  
Newtonian Flow ◽  
Eudragit Rs ◽  
In Situ Forming ◽  
Eudragit Rs 30D ◽  
In Situ Forming Gel ◽  
Local Drug Delivery System ◽  
Release Form

Capsaicin exhibits the analgesic and anti-inflammatory activities, therefore it is interesting to apply this natural active compound for periodontitis treatment by local drug delivery system such as intra-canal route. Capsaicin in-situ forming gels were prepared in this research work. The viscosity, gel forming property and capsaicin release were evaluated. 30%W/W eudragit RS 30D in N-methylpyrrolidone (NMP) employed as gel base was physicaly stable after sterilization with autoclaving and exhibited the in-situ forming gel property. This gel base was still clear when capsaicin was less than 0.0094 %w/w. When the system contacted with phosphate buffer pH 6.8 the turbid gel was appeared rapidly at the interface. Viscosity of system depended on the amount of eudragit RS 30D. The rheology of systems was newtonian flow and amount of capsaicin tincture did not affect the rheological behavior. The release rate and amount of capsaicin release form gels were lower than those of capsaicin solution. The sustainable release of capsaicin could be obtained from the developed in-situ forming gel.

Injectable in-situ Forming Depot Of Doxycycline Hyclate/α-Cyclodextrin Complex using PLGA for Periodontitis Treatment: Preparation, Charac-terization, and In-Vitro Evaluation

2020 ◽  
Vol 17 ◽  
Author(s):  
Elham Khodaverdi ◽  
Farhad Eisvand ◽  
Mohammad Sina Nezami ◽  
Seyedeh Nesa Rezaeian Shiadeh ◽  
Hossein Kamali ◽  
...  
Keyword(s):  
Complex Form ◽  
Docking Studies ◽  
Morphological Properties ◽  
Burst Release ◽  
Cyclodextrin Complex ◽  
Doxycycline Hyclate ◽  
Scanning Calorimetry ◽  
In Situ Forming

Background:: Doxycycline (DOX) is used in treating a bacterial infection, especially for periodontitis treatment. Objective: To reduce irritation of DOX for subgingival administration and increase the chemical stability and against enzy-matic, the complex of α-cyclodextrin with DOX was prepared and loaded into injectable in situ forming implant based on PLGA. Methods:: FTIR, molecular docking studies, X-ray diffraction, and differential scanning calorimetry was performed to char-acterize the DOX/α-cyclodextrin complex. Finally, the in-vitro drug release and modeling, morphological properties, and cellular cytotoxic effects were also evaluated. Results:: The stability of DOX was improved with complex than pure DOX. The main advantage of the complex is the al-most complete release (96.31 ± 2.56 %) of the drug within 14 days of the implant, whereas in the formulation containing the pure DOX and the physical mixture the DOX with α-cyclodextrin release is reached to 70.18 ± 3.61 % and 77.03 ± 3.56 %, respectively. This trend is due to elevate of DOX stability in the DOX/ α-cyclodextrin complex form within PLGA implant that confirmed by the results of stability. Conclusion:: Our results were indicative that the formulation containing DOX/α-cyclodextrin complex was biocompatible and sustained-release with minimum initial burst release.

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