Peppermint oil/doxycycline hyclate-loaded Eudragit RS in situ forming gel for periodontitis treatment

2017 ◽  
Vol 48 (4) ◽  
pp. 451-464 ◽  
Author(s):  
Thawatchai Phaechamud ◽  
Jongjan Mahadlek ◽  
Sarun Tuntarawongsa
Keyword(s):  
Peppermint Oil ◽  
Doxycycline Hyclate ◽  
Eudragit Rs ◽  
In Situ Forming ◽  
In Situ Forming Gel

Emerging role of polyethylene glycol on doxycycline hyclate-incorporated Eudragit RS in situ forming gel for periodontitis treatment

2019 ◽  
Vol 50 (1) ◽  
pp. 81-94 ◽  
Author(s):  
Wai Wai Lwin ◽  
Napaphol Puyathorn ◽  
Setthapong Senarat ◽  
Jongjan Mahadlek ◽  
Thawatchai Phaechamud
Keyword(s):  
Polyethylene Glycol ◽  
Doxycycline Hyclate ◽  
Eudragit Rs ◽  
In Situ Forming ◽  
In Situ Forming Gel

Benzoyl Peroxide In Situ Forming Antimicrobial Gel for Periodontitis Treatment

2013 ◽  
Vol 545 ◽  
pp. 63-68 ◽  
Author(s):  
Jongjan Mahadlek ◽  
Juree Charoenteeraboon ◽  
Thawatchai Phaechamud
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Activity ◽  
Drug Release ◽  
Delivery System ◽  
Periodontal Pocket ◽  
Peppermint Oil ◽  
In Situ Gel ◽  
In Situ Forming ◽  
In Situ Forming Gel

Periodontitis is an inflammatory disease of the supporting structures of the tooth caused by bacterial infection which can result in tooth loss. The local intra-pocket drug delivery system was interesting and highly effective for periodontitis treatment. In situ forming gel system is the polymeric solution which could transform into gel for localizing and sustaining the drug release at desired site. This system has been recommended as one of suitable delivery system for this purpose. Benzoyl peroxide (BPO) in situ forming gels were developed using Eudragit RS as polymer dispersed in N-methyl-pyrrolidone (NMP). Peppermint oil and polyethylene glycol 1500 were also incorporated as the excipients. The prepared systems were evaluated for rheology, syringeability (using texture analyzers), in situ gel formation (after injection into PBS pH 6.8), antimicrobial activity (against Streptococcus mutans with agar diffusion) and drug release (with dialysis method in PBS pH 6.8 at 50 rpm, 37 °C). The viscosity and syringeability of the prepared systems was increased as the amount of BPO, peppermint oil or PEG 1500 was increased. All prepared gels showed the Newtonian flow which the viscosity was decreased as the temperature was increased. All prepared gels comprising peppermint oil and PEG 1500 could form in situ gel in used medium which the pH was close to the environment pH of periodontal pocket. The inhibition zone against Streptococcus mutans of the prepared system was significantly decreased when the peppermint oil and PEG 1500 was incorporated owing to the higher viscous environment and thereafter retardation of drug diffusion was evident. This effect could prolong the drug release. From drug release test, all prepared gels could sustain the BPO release for at least 96 hrs. Release kinetic obtained from curve fitting with various release equations using least square fit technique indicated that the release patterns were as Higuchi’s model therefore the release of BPO was performed with diffusion control. This developed BPO in situ forming gel presented its ability as the controlled drug delivery system for localized antimicrobial activity at periodontal pocket.

Capsaicin Injectable In-Situ Forming Gels

2012 ◽  
Vol 528 ◽  
pp. 103-106
Author(s):  
Thawatchai Phaechamud ◽  
Sarun Tuntarawongsa
Keyword(s):  
Research Work ◽  
Local Drug Delivery ◽  
Newtonian Flow ◽  
Eudragit Rs ◽  
In Situ Forming ◽  
Eudragit Rs 30D ◽  
In Situ Forming Gel ◽  
Local Drug Delivery System ◽  
Release Form

Capsaicin exhibits the analgesic and anti-inflammatory activities, therefore it is interesting to apply this natural active compound for periodontitis treatment by local drug delivery system such as intra-canal route. Capsaicin in-situ forming gels were prepared in this research work. The viscosity, gel forming property and capsaicin release were evaluated. 30%W/W eudragit RS 30D in N-methylpyrrolidone (NMP) employed as gel base was physicaly stable after sterilization with autoclaving and exhibited the in-situ forming gel property. This gel base was still clear when capsaicin was less than 0.0094 %w/w. When the system contacted with phosphate buffer pH 6.8 the turbid gel was appeared rapidly at the interface. Viscosity of system depended on the amount of eudragit RS 30D. The rheology of systems was newtonian flow and amount of capsaicin tincture did not affect the rheological behavior. The release rate and amount of capsaicin release form gels were lower than those of capsaicin solution. The sustainable release of capsaicin could be obtained from the developed in-situ forming gel.

Injectable in-situ Forming Depot Of Doxycycline Hyclate/α-Cyclodextrin Complex using PLGA for Periodontitis Treatment: Preparation, Charac-terization, and In-Vitro Evaluation

2020 ◽  
Vol 17 ◽  
Author(s):  
Elham Khodaverdi ◽  
Farhad Eisvand ◽  
Mohammad Sina Nezami ◽  
Seyedeh Nesa Rezaeian Shiadeh ◽  
Hossein Kamali ◽  
...  
Keyword(s):  
Complex Form ◽  
Docking Studies ◽  
Morphological Properties ◽  
Burst Release ◽  
Cyclodextrin Complex ◽  
Doxycycline Hyclate ◽  
Scanning Calorimetry ◽  
In Situ Forming

Background:: Doxycycline (DOX) is used in treating a bacterial infection, especially for periodontitis treatment. Objective: To reduce irritation of DOX for subgingival administration and increase the chemical stability and against enzy-matic, the complex of α-cyclodextrin with DOX was prepared and loaded into injectable in situ forming implant based on PLGA. Methods:: FTIR, molecular docking studies, X-ray diffraction, and differential scanning calorimetry was performed to char-acterize the DOX/α-cyclodextrin complex. Finally, the in-vitro drug release and modeling, morphological properties, and cellular cytotoxic effects were also evaluated. Results:: The stability of DOX was improved with complex than pure DOX. The main advantage of the complex is the al-most complete release (96.31 ± 2.56 %) of the drug within 14 days of the implant, whereas in the formulation containing the pure DOX and the physical mixture the DOX with α-cyclodextrin release is reached to 70.18 ± 3.61 % and 77.03 ± 3.56 %, respectively. This trend is due to elevate of DOX stability in the DOX/ α-cyclodextrin complex form within PLGA implant that confirmed by the results of stability. Conclusion:: Our results were indicative that the formulation containing DOX/α-cyclodextrin complex was biocompatible and sustained-release with minimum initial burst release.

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