scholarly journals Doxycycline hyclate-loaded in situ forming gels composed from bleached shellac, Ethocel, and Eudragit RS for periodontal pocket delivery

2021 ◽  
Vol 29 (3) ◽  
pp. 252-263
Author(s):  
Setthapong Senarat ◽  
Wai Wai Lwin ◽  
Jongjan Mahadlek ◽  
Thawatchai Phaechamud
Keyword(s):  
Periodontal Pocket ◽  
Doxycycline Hyclate ◽  
Eudragit Rs ◽  
In Situ Forming ◽  
Bleached Shellac

Phase Behavior of Doxycycline Hyclate-Incorporated Bleached Shellac In Situ Forming Gel/Microparticle after Solvent Movement

2020 ◽  
Vol 859 ◽  
pp. 21-26
Author(s):  
Setthapong Senarat ◽  
Juree Charoenteeraboon ◽  
Pitsiree Praphanwittaya ◽  
Thawatchai Phaechamud
Keyword(s):  
Phase Behavior ◽  
Periodontal Pocket ◽  
Dense Matrix ◽  
Doxycycline Hyclate ◽  
Solvent Type ◽  
External Phase ◽  
The Matrix ◽  
Methyl Pyrrolidone ◽  
Bleached Shellac

With regard to the periodontal pocket application of in situ forming systems, the understanding the phase behavior after solidification owing to solvent movement could verify the deformability of specimen and its capacity to reside in the artificial periodontal pocket. The aim of this research was to investigate the phase behavior by determining mechanical properties as hardness and elasticity/plasticity ratio with texture analyzer for matrices obtained from drug-free and doxycycline hyclate (DX)-incorporated bleached shellac (BS) in situ forming gel (isg) and –microparticle (ism) after solvent exchange. The solvents for dissolving BS were 2-pyrrolidone (PYR), N-methyl pyrrolidone (NMP) and dimethyl sulfoxide (DMSO). The matrix from isg was less rough and bulge than that of isg. The order of mechanical hardness of transformed system prepared with different solvents was presented as PYR > NMP > DMSO, influenced by phase separation rate and porosity. The systems prepared with NMP and DMSO were more likely plastic or able to adapt its geometry to dynamic changes while that prepared with PYR was elastic. DX-incorporated ism matrix was still governed by the oil in external phase; thus, its consequence was reasonably plastic instead. XRD pattern indicated that the solvent type had no effect on the crystallinity of remained BS after solvent movement. SEM topography revealed sponge-like structure of isg prepared with DMSO and NMP whereas that prepared with PYR exhibited only initiated diminutive pores. The size and density of pores increased by time of isg using different solvents as following DMSO > NMP > PYR, whereas ism matrices had less pore density. The level of porosity of each matrix reflected the mechanical strength that a higher porous structure collapsed easily but a dense matrix considerably resisted to a compression.

Emerging role of polyethylene glycol on doxycycline hyclate-incorporated Eudragit RS in situ forming gel for periodontitis treatment

2019 ◽  
Vol 50 (1) ◽  
pp. 81-94 ◽  
Author(s):  
Wai Wai Lwin ◽  
Napaphol Puyathorn ◽  
Setthapong Senarat ◽  
Jongjan Mahadlek ◽  
Thawatchai Phaechamud
Keyword(s):  
Polyethylene Glycol ◽  
Doxycycline Hyclate ◽  
Eudragit Rs ◽  
In Situ Forming ◽  
In Situ Forming Gel

Injectable in-situ Forming Depot Of Doxycycline Hyclate/α-Cyclodextrin Complex using PLGA for Periodontitis Treatment: Preparation, Charac-terization, and In-Vitro Evaluation

2020 ◽  
Vol 17 ◽  
Author(s):  
Elham Khodaverdi ◽  
Farhad Eisvand ◽  
Mohammad Sina Nezami ◽  
Seyedeh Nesa Rezaeian Shiadeh ◽  
Hossein Kamali ◽  
...  
Keyword(s):  
Complex Form ◽  
Docking Studies ◽  
Morphological Properties ◽  
Burst Release ◽  
Cyclodextrin Complex ◽  
Doxycycline Hyclate ◽  
Scanning Calorimetry ◽  
In Situ Forming

Background:: Doxycycline (DOX) is used in treating a bacterial infection, especially for periodontitis treatment. Objective: To reduce irritation of DOX for subgingival administration and increase the chemical stability and against enzy-matic, the complex of α-cyclodextrin with DOX was prepared and loaded into injectable in situ forming implant based on PLGA. Methods:: FTIR, molecular docking studies, X-ray diffraction, and differential scanning calorimetry was performed to char-acterize the DOX/α-cyclodextrin complex. Finally, the in-vitro drug release and modeling, morphological properties, and cellular cytotoxic effects were also evaluated. Results:: The stability of DOX was improved with complex than pure DOX. The main advantage of the complex is the al-most complete release (96.31 ± 2.56 %) of the drug within 14 days of the implant, whereas in the formulation containing the pure DOX and the physical mixture the DOX with α-cyclodextrin release is reached to 70.18 ± 3.61 % and 77.03 ± 3.56 %, respectively. This trend is due to elevate of DOX stability in the DOX/ α-cyclodextrin complex form within PLGA implant that confirmed by the results of stability. Conclusion:: Our results were indicative that the formulation containing DOX/α-cyclodextrin complex was biocompatible and sustained-release with minimum initial burst release.

Sign in / Sign up

Export Citation Format

Share Document