Aneusomaty and Chromosomal Chimeras in Male Track of Coccinia grandis (L.) Voigt

2021 ◽  
Author(s):  
Priya Sharma ◽  
Namrata Sharma
Keyword(s):  
Coccinia Grandis

Efficacy of Coccinia grandis against monosodium glutamate induced hepato-cardiac anomalies by inhibiting NF-kB and caspase 3 mediated signalling in rat model

2021 ◽  
pp. 096032712110108
Author(s):  
Arnab Banerjee ◽  
Sandip Mukherjee ◽  
Bithin Kumar Maji
Keyword(s):  
Bioactive Compounds ◽  
Caspase 3 ◽  
Protective Efficacy ◽  
Monosodium Glutamate ◽  
Scientific Information ◽  
Cellular Damage ◽  
Inflammatory Factors ◽  
Cardiac Damage ◽  
Coccinia Grandis ◽  
Microvascular Proliferation

Since prehistoric times Coccinia grandis has been used as traditional medicine for various diseases including diabetes, dyslipidemia, metabolic and digestive disorders. Although the rationality of efficacy as natural antioxidants with different bioactive compounds in Coccinia grandis against monosodium glutamate (MSG) induced hepato-cardiac damage remains to be disclosed. Six different solvent extracts of the leaves of Coccinia grandis were chosen to evaluate in vitro antioxidant and free radical (FR)-scavenging activity. Due to high antioxidant content and FR-scavenging property of ethanol extract of Coccinia grandis leaves (EECGL) and presence of different bioactive compounds in EECGL was further tested to evaluate in vivo hepato-protective and cardio-protective efficacy against MSG-induced anomalies. MSG-induced dyslipidemia, increased cell toxicity markers altered functional status and histopathological peculiarities of target organs were blunted by EECGL. Additionally, MSG incited increase level of interleukin (IL)-6, tumour necrosis factor (TNF)-α, IL-1β which activates nuclear factor kappa-B (NF-kB) guided inflammation via down regulation of IL-10; impaired redox-homeostasis subsequently promoted inflammation associated oxidative stress (OS) and increased vascular endothelial growth factor (VEGF) which provoked microvascular proliferation related cellular damage. On the contrary, increased lipid peroxidation and nitric oxide promotes reduced cell viability, deoxyribonucleic acid damage and apoptosis via activation of caspase 3. EECGL significantly reduced MSG-induced inflammation mediated OS and apoptosis via inhibition of pro-inflammatory factors and pro-apoptotic mediators to protect liver and heart. Therefore, it can be suggested that EECGL contributed competent scientific information to validate the demands for its use to treat MSG-induced hepato-cardiac OS mediated inflammation and apoptosis from natural origin.

Multiple microRNAs Regulate the Floral Development and Sex Differentiation in the Dioecious Cucurbit Coccinia grandis (L.) Voigt

2019 ◽  
Vol 37 (1-2) ◽  
pp. 111-128 ◽  
Author(s):  
Jatindra Nath Mohanty ◽  
Subodh Kumar Chand ◽  
Raj Kumar Joshi
Keyword(s):  
Floral Development ◽  
Sex Differentiation ◽  
Coccinia Grandis

Coccinia grandis (L.) Voigt Cucurbitaceae

2021 ◽  
pp. 583-590
Author(s):  
Prakash Prasad Sapkota ◽  
Ripu M. Kunwar ◽  
Hammad Ahmad Jan ◽  
Rainer W. Bussmann ◽  
Narel Y. Paniagua-Zambrana
Keyword(s):  
Coccinia Grandis

Coccinia grandis (L.) Voigt Cucurbitaceae

2021 ◽  
pp. 309-311
Author(s):  
Rainer W. Bussmann ◽  
Narel Y. Paniagua-Zambrana ◽  
Grace N. Njoroge
Keyword(s):  
Coccinia Grandis

scholarly journals Evaluation of hepatoprotective activity of the fruits of coccinia grandis linn

2010 ◽  
Vol 1 (3) ◽  
Author(s):  
R Vadivu ◽  
A Krithika ◽  
C Biplab ◽  
P Dedeepya ◽  
N Shoeb ◽  
...  
Keyword(s):  
Hepatoprotective Activity ◽  
Coccinia Grandis

Isolated Sieve Tubes in the Fruit of Coccinia grandis (L.) Voight (Cucurbitaceae)

1983 ◽  
Vol 51 (2) ◽  
pp. 251-253 ◽  
Author(s):  
J. J. SHAH ◽  
G. M. NAIR ◽  
Y. J. THANKI ◽  
I. L. KOTHARI
Keyword(s):  
Coccinia Grandis ◽  
Sieve Tubes

Development of a Virus‐Induced Gene Silencing System for Dioecious Coccinia grandis

2020 ◽  
Vol 62 (9) ◽  
pp. 412-422
Author(s):  
Ravi Suresh Devani ◽  
Apurva Kute ◽  
Sheeba John ◽  
Supriya Adhikari ◽  
Sangram Sinha ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Virus Induced Gene Silencing ◽  
Coccinia Grandis

scholarly journals Mechanistic study of attenuation of monosodium glutamate mixed high lipid diet induced systemic damage in rats by Coccinia grandis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Arnab Banerjee ◽  
Debasmita Das ◽  
Rajarshi Paul ◽  
Sandipan Roy ◽  
Ujjal Das ◽  
...  
Keyword(s):  
Monosodium Glutamate ◽  
Ethanol Extract ◽  
Inflammatory Factors ◽  
Mechanistic Study ◽  
Metabolic Disturbances ◽  
Alcoholic Fatty Liver ◽  
Coccinia Grandis ◽  
High Lipid ◽  
High Lipid Diet ◽  
Lipid Diet

Abstract In the context of failure of treatment for non alcoholic fatty liver disease (NAFLD)-mediated systemic damages, recognition of novel and successful characteristic drug to combat these anomalous situations is earnestly required. The present study is aimed to evaluate protective value of ethanol extract of Coccinia grandis leaves (EECGL), naturally occurring medicinal plant, on NAFLD-mediated systemic damage induced by high lipid diet along with monosodium glutamate (HM)-fed rats. Our study uncovered that EECGL significantly ameliorates HM-induced hyperlipidemia, increased lipogenesis and metabolic disturbances (via up regulation of PPAR-α and PPAR-γ), oxidative stress (via reducing the generation of reactive oxygen species and regulating the redox-homeostasis) and inflammatory response (via regulating the pro-inflammatory and anti-inflammatory factors with concomitant down regulation of NF-kB, iNOS, TNF-α and up regulation of eNOS). Furthermore, EECGL significantly inhibited HM-induced increased population of cells in sub G0/G1 phase, decreased Bcl2 expression and thereby loss of mitochondrial membrane potential with over expression of Bax, p53, p21, activation of caspase 3 and 9 indicated the apoptosis and suppression of cell survival. It is perhaps the first comprehensive study with a mechanistic approach which provides a strong unique strategy for the management of HM-induced systemic damage with effective dose of EECGL.

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