Waldmann’s Disease Revealed by Chronic Diarrhea and Lymphedema: Case Report

Intestinal lymphangiesctasia (IL) is a rare disease characterized by the dilation of intestinal lymphatics. It can be classified as primary or secondary depending on the underlying etiology. Usually seen in childhood or adolescence, chronic diarrhea and diffuse edema are the main clinical manifestations of the disease. True lymphoedemas can also be present and affect the lower and upper limbs, they are concomitant with the diagnosis or occur during the course. The diagnosis is based on the visualization of duodenal lymphangiesctasia. The primitive nature of the disease being affirmed by the elimination of the diseases causing secondary lymphangiectasias. Treatment is based on a strict hypo lipid diet enriched with medium chain triglycerides (MCTs). We present through this work the observation of a 12-month-old infant who presented with primary intestinal lymphangiesctasia revealed by chronic diarrhea with lymphoedema of the left upper limb.

Liver Steatosis is a Component of the Hepatocardiorenal Syndrome Provoked by a High-Lipid Diet and Activation of Ang II Pathways in Rats

Overweight/obesity is a growing pandemic nowadays that affects many organs and tissues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver alterations associated with previously described cardiovascular and kidney disturbances. Chronic administration of a high-lipid diet can provoke an hepatocardiorenal syndrome as the result of activation of the Ang II→type 1 receptor axis, which is completely counteracted by Ang-(3–4) the allosteric enhancer of the Ang II→type 2 receptor pathway.

EFFECT OF AMMONIUM PYRROLIDINE DITHIOCARBAMBATE ON THE FORMATION OF RACTIVE OXYGEN AND NITROGEN SPECIES IN LIVER OF RATS KEPT ON CARBOHYDRATE-LIPID DIET AND EXPOSED TO ROUND-THE-CLOCK LIGHTING

This aim of the experiment performed on 21 white rats is to clear up the effect of the nuclear factor kappa B (NF-kappa B) inhibitor on the production of reactive oxygen and nitrogen species in the liver of animals kept on carbohydrate-lipid diet and exposed to round-the-clock lighting. The study has demonstrated the administration of ammonium pyrrolidine diothiocarbamate (76 mg/kg three times a week, starting on the 30th day of the experiment) under the conditions of high-calorie carbohydrate-lipid diet (60 days) and exposure of the test animals to round-the-clock light (1500 lux for the last 30 days of the experiment) reduces the production of superoxide anion radical in the liver tissues by NADPH- and NADH-dependent electron transport chains by 45.2% and 43.5%. The production of this radical by leukocytes by NADPH oxidase was 41.6% lower than in the comparison group. The activity of NO-synthase (total and its inducible isoenzyme) decreased by 34.4 and 29.8%, the activity of the constitutive isoform increased threefold. The coupling index of the latter elevated by 5.16 times that indicates the restoration of the coupling state of this isoenzyme. The decrease in the generation of superoxide anion radical and nitric oxide was accompanied by lowering in the peroxynitrites concentration by 36.4%. We can conclude that the administration of ammonium pyrrolidine dithiocarbamate, an NF-kappa B inhibitor, during the metabolic syndrome simulated in rats by round-the-clock lightening exposure and diet rich in carbohydrates and fats is an effective means to restrict the production of reactive oxygen species.

Myo-inositol improves growth performance and regulates lipid metabolism of juvenile Chinese mitten crab (Eriocheir sinensis) fed different percentage of lipid

This study evaluated the effects of dietary myo-inositol (MI) on growth performance, body composition, antioxidant status and lipid metabolism of juvenile Chinese mitten crab (Eriocheir sinensis) fed different percentage of lipid. Crabs (4.58 ± 0.05 g) were fed four diets including a normal lipid diet (N, containing 7% lipid and 0 mg/kg MI), N with MI supplementation (N+MI, containing 7% lipid and 1600 mg/kg MI), a high lipid diet (H, containing 13% lipid and 0 mg/kg MI) and H with MI supplementation (H+MI, containing 13% lipid and 1600 mg/kg MI) for 8 weeks. The H+MI group showed higher weight gain and specific growth rate than those in the H group. The dietary MI could improve the reduction of whole-body protein content, low MI content in the hepatopancreas, and lipid accumulations in the whole-body, hepatopancreas and muscle as a result of feeding on the high dietary lipid (13%) in crabs. Besides, the crabs fed the H+MI diets increased the activities of antioxidant enzymes, but reduced the malondialdehyde content in hepatopancreas compared with those fed the H diets. Moreover, dietary MI enhanced the expression of genes involved in lipid oxidation and exportation, yet reduced lipid absorption and synthesis genes expression in the hepatopancreas of crabs fed the H diet, which might be related to the activation of IP3R/CaMKKβ/AMPK signalling pathway. This study demonstrates that MI could increase lipid utilization and reduce lipid deposition in the hepatopancreas of E. sinensis fed a high lipid diet through IP3R/CaMKKβ/AMPK activation. This work provides new insights into the function of MI in the diet of crustaceans.

Influence of Non-protein Diets on Hepatic Metabolism and Endocrine in Barramundi (Lates calcarifer)

This study evaluated the effects of different dietary non-protein energy sources on hepatic metabolism and endocrine of barramundi. Fish were fed iso-energy diets (18 MJ kg–1) with two types of non-protein energy source in the experimental group and a regular diet was used as the control. The feeding trial lasted 56 days. In the present study, CPT1 and SCD expression in fish fed high lipid diet were upregulated and liver lipid metabolism was more active than the control group. Serum biochemical parameters including serum glucose, serum triacylglycerol and serum cholesterol were significantly increased. The IGF-I and IGF-II expressions were significantly upregulated, and growth performances were improved in fish fed the high lipid diet. When barramundi were fed with the high carbohydrate diet, GK expression was downregulated and cPEPCK expression was upregulated, indicating that glycogen might accumulate in liver. The fluctuation of serum biochemical parameters and the growth performance were not significantly different compared to the control group. In conclusion, high lipid diet can shorten the raising period, but it causes the change of metabolic level and the increase of useless adipose tissue; The high carbohydrate diet did not significantly improve the growth performance, and no significant metabolic abnormalities were observed, indicating that carbohydrate has the potential to be the feed energy supply source for juvenile barramundi. The results provide insights for further understanding the availability of non-protein energy sources in the diet of juvenile barramundi.